<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06583

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMFARSPVKENELLDLLLEARASSSVTWDPLLPLYVDGLCKVGRVKSSSALASLLKHSSIVDASGSGEVEGEGQGSPSKSKKQKPSTLMTDIKVIQDVMVFISTGSIPKTVIEAADIYSATVDWILAVVAWHNHSVDASQQTGGLMGSPDAVSLFESLGILLAALSGTNKGLEVLSSDFNQALKAKLGQALSSYLPLCIDVSLPLRHRLEELQKVFNLYPGQPSKALNGPAIDGVNVNALQFESSVMDGPVVNTRAGLYVYINSMVVGRPLVDDTILINYLTNRYQGHNDVLIEEIITAAFDVLSNGVYRNESGRTMLLFRSFLVNKLPAFFAAISAASMVPISMEMCISHALSRLDPNAFPSFSQMFSMQGSSVLSDARQEFLFACASHKLIRESSIEQLLGENPMQTLPGGGPYVKDDLVSQINNNHERTEQLIGEIESMEGNAGAIVGAVVDVMHNLCHQRETMTLKNICNSLSRRPQTLDVMLLFRTTKQVLQPLCAILDSWKWDEDQGENQPVYDEFGSILLLVLAFKYRYDLSPSDMGISNNDSFLLKLLDRGACSQKLSDLSEKQNNDLGAWIGALFIAEGISEETMSSCSPHEFYMLVTTLFDQSLGACESGKLDFDTLKGGFEYLLEPFLLPSLVVALTWLGNHIWESETDPTIPIKTLHSLVKPSSISGEAQAIHQTVLNITGCPLEEQLKNVRTRNQSRTDIKPILDALEPYISFRRVGSCRRSELDTWTSHSPGGLIASIRTTLQALVLWSANPGISMAPHAYTHRQVLAGIRMLGATRVLCAIIDEVKQQTEAGSGHIALDIATTMVCAPMTESFAVDQNNYHPVDTSKEALPRCAILTLRDALALQHENVPKISESDPLRAEVVVRLARRVNMLMAPPSQVSNIDVSNIIQNMHLGVEGQEDRMDLEPSTAGVARTTDHEDDPDNINQMLDKAAADAAAAGMDGGIDVGQDMGLDSGAGMDAIDDVLNAADMAVGNPEFLDLDMEGMF
Length1001
PositionTail
OrganismPenicillium freii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.06
Grand average of hydropathy-0.026
Instability index44.33
Isoelectric point4.80
Molecular weight108914.92
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06583
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.75|      21|      26|     820|     840|       1
---------------------------------------------------------------------------
  820-  840 (39.29/28.39)	CAPMT..ESFAVDQNNYHPVDTS
  847-  869 (30.45/20.24)	CAILTlrDALALQHENVPKISES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.68|      20|      26|     454|     475|       2
---------------------------------------------------------------------------
  454-  475 (32.21/33.31)	DVMhnLCHQRETMTLKNICNSL
  483-  502 (34.47/26.36)	DVM..LLFRTTKQVLQPLCAIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.69|      21|      26|     915|     935|       3
---------------------------------------------------------------------------
  915-  935 (36.23/25.52)	DRMDLEPSTAGVARTTDHEDD
  944-  964 (34.46/23.87)	DKAAADAAAAGMDGGIDVGQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     256.79|      77|     620|      28|     108|       4
---------------------------------------------------------------------------
   28-  108 (126.69/91.21)	DPLLPLY......VDGLCKVG.RVKSSS........ALASLLKHSSIVDASGSGEVEGEGQ......GSP.......SKSKKQKPstlmTDIKVIQDVM.VFIS...TGSIPK
  122-  170 (43.68/22.11)	DWILAVVawhnhsVDASQQTG.GLMGSP........DAVSLFESLGILLAALSGTNKG.......................................................
  638-  733 (86.43/53.60)	..LLPSL......VVALTWLGnHIWESEtdptipikTLHSLVKPSSI.....SGEAQAIHQtvlnitGCPleeqlknVRTRNQSR....TDIKPILDALePYISfrrVGSCRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.90|      12|      23|     579|     596|       6
---------------------------------------------------------------------------
  579-  596 (14.92/18.33)	IGALFiaegisEETMSSC
  605-  616 (20.98/ 9.92)	VTTLF......DQSLGAC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.24|      12|      31|     398|     411|       7
---------------------------------------------------------------------------
  398-  411 (17.66/18.83)	EQLLGEnpMQTLPG
  432-  443 (21.58/13.46)	EQLIGE..IESMEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.92|      21|      26|     321|     345|       8
---------------------------------------------------------------------------
  321-  345 (29.42/23.93)	SFLVNKL.PAFFAAISAAsmvpISME
  349-  370 (34.51/17.92)	SHALSRLdPNAFPSFSQM....FSMQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06583 with Med5 domain of Kingdom Fungi
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