<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06580

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGANTNIHLIDGFSNIYWRIYTEEAGITNNPQESPANGYTILKHLSRLKDLEARLRGLNCLASCPRRLGLWVFSPTPEFESLNPLYVRGSDAESNRIVVGTTILKVSALGSVSSLDLVKGLSSDNQSQHGTQPAGQPRLHQGQPSPRRQDGYSSSAAIYASFISAVTGSIGLQLIRRHAALPLGSRTLFTAVEKSGYESPHINNDNILSTPCLTTLNIQLTMSGTITVSAQTISQAGITRLCSLHEDISERIDVQPGIDLWLCPNGTIAKLVTANIDSPTVPSLGYPAPGNLSAKKLQWKLDVVQWLRNFGLHVGSIDEEPWVEVEVWEPFFARLAGEAWRQSDDSQTALPLKRMLWPARFCFRRASSSSFSSGAQTSLLDEPLDFAERWSTMASSLTLDHISHTAQNTPITQDPQPKDQEMLSPLKPEPLESIESLSRIAQYPDLQSTNLVYPTPPDGTAAVGLNNPNPSEAFADDSDFGLPRAAQRSSRRNAPGSDISPVQNSGVGVGTGRYDASDEEDLFGELNERDFGSKGITDADFSFFDDPDFDGMEGNSLVEDAAEVLEASHPPSEPEAEAMVDAEPSPNQPQAIPTHVETHEAHASPIYDEAPRLSEEPMAPEEPAHSPMDRAGQTISPPLSPVEVKKILFPGPEADDHQQSTDNRGQGHYRPVEFEKKLGDWDQKYGTAGKFWFSSGGTLDTLDQTSSIPTIGMPHRGRSSANAPGSSKERSKPSLSLTQSENGLRSASVSSDSSDDSIEIMSEHVPTPAALPSIPSLKRKRAPSESDIISIASQERSLPVTEASPTYAAENSTFLGNFLANFSDWTLTGYFSAFPPQQLPVLFRREGQLEIAQLLVDQITQSSLKHPLDGQIGLFDLESESLSLQALDDTTILGETSKMDFKRYTSLQDEFVAGQLQQQPPQHPPPPKETPKSFISKLSAPHIRVRRGKEYLEALPPAVSFWETFGLEPAHGPKNISAYCIHPQAASKAADVFMTRFGLLYQSCSLGTHTRGDDSVAFEDGLRPWKSETSSYESMMQVLKRTCEQLGSELSQSPATADNNVVYIINPFTHAAALADICSAFWHLFQQLVAGSERRQTRISNELVLQIIPLEFVMSSETMVIPPETDYLNLALEVYSRCRPDDADMSPLLCAPPMLLADTLPRAISFRLAPERSSPLQDGRSLHIAYSKSLDQRWISVAWSDLSGSMQRTMSYCLRYRQSSGARPVSEVRNEIWATTKQIMDKFQARWKVQLVTTEPIETDEVEAWASLADQHNKLRPGSLELTILAVNTVPDLILEPPVPPISMAMLNILSSSTPVSTPNPSVSVASPEQSGNAATPNSAGPAAYNAPTPTEMSLETDSEAVLADICDDSWLAILSHRLNSSPHLTEFRPALSSGYLLRRKGATDGDGVFAISVNLIYSPRPPSSHDNVLKDTLSMYRDLGCLARAKGICSVQNNTLPWHVATALRGQELLSYVF
Length1479
PositionKinase
OrganismPenicillium freii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.371
Instability index59.84
Isoelectric point4.98
Molecular weight161717.12
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06580
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     822.36|     235|     552|     607|     851|       1
---------------------------------------------------------------------------
  325-  528 (211.00/106.72)	......................................PWVEVEVWEPFFARLAGEAWRQSDDSQT.....ALPLKRML..WPARfcFRRASSSSFSSGAQTSLLDEpldfaerwSTMASSLTLDHISHTAQ.............NTPITQDPQPKDQEMLSP....LK....................PEP..LESIESLSR............IAQYPDLQSTNlVYPT.PPDGTAAVGlnnpnpsEAFADDSDFGLpraaqrssrrnapgsdispvqnsgvgvgTGRYDASDEED...LF...G
  607-  851 (378.67/221.79)	ASPIYDEAPRLSEEPMAPEEPAHSPMDR..AGQ.TISPPLSPVEVKKILFPGPEADDHQQSTDNRGQGHYRPVEFEKKLGDWDQK..YGTAGKFWFSSGGTLDTLDQ........TSSIPTIGMPHRGRSSA.............NAPGSSKERSKPSLSLTQsENGLRSASVSSDSSDDSIEIMSEhvPTPAALPSIPSLKRKRAPSESDIISIASQERSLPVTE.ASPTyAAENSTFLG.......NFLANFSDWTL............................TGYFSAFPPQQlpvLFrreG
  887- 1068 (232.68/117.03)	SLQALDDTTILGETSKMDFKRYTSLQDEfvAGQlQQQPP.........QHPPPPKETPKSFISKLSAPHIRV....RRGKEYLEA..LPPAVSFWETFG..LEPAHG........PKNISAYCIHPQAASKAadvfmtrfgllyqSCSLGTHTRGDDSVAF...EDGLRPWKSETSSYESMMQVLKR...TCEQLGS..ELSQSPATADNNVVYI............................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.35|      39|     133|    1126|    1165|       2
---------------------------------------------------------------------------
 1126- 1165 (68.55/50.05)	PPETD....YLNLAlEVYSRCRPDDADMSPLL..CAPPMLLADTLP
 1260- 1304 (58.80/37.66)	PIETDeveaWASLA.DQHNKLRPGSLELTILAvnTVPDLILEPPVP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06580 with Med13 domain of Kingdom Fungi
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