<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06575

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGSITNIRAIDGFSHIYWRIYTDDPGESPSNGYAILKHLSRLKDLELQLRDRNCLVSSYPRRLCLWVFSATPGFESLLPLSPNDGRDDSGRLAIGSATLKVSSSGNVSALDLVKNLSTETQNASGTAGSQRPNAMTPFATIYASFISAVSGAVSLQLVRQRNAIPLGSRTLFTVVEKDGCDNSHVSKNDLALAPSLTTLQIQLTSPGKLTVALQTVSQAGLTRLLTPEEVPASIHDTPPGTDLWLSPSGSIARLVAANPPQLNAGSPYPSNVGGSGNEKSSPATRKQWKVNVLWWLSNFGLPVDGIDDEAWVEVEVWEPFYSRLAGEVWRPSEEGASMLPLKRILWPAIYCFRRTKSASSVFYGEMEGVSSIAGDPLDFAEKWRVTEKLSFAEASPKPPSVHQEAPTRDQDASSPDLLNLPEGIESLSRASQYPDLQTASLVYPTPPDGAAATGLNPMVTSDAFADDIEQSSTFMQQDRQNHHRQLSKERTGTDVISFGPSAGLVVGSGLYDTNDDDDLFGDINEKDFGTKGITDADFSFFDDPDFDRGGVGEQAEAIQELSGFMDTDEPEIQPTVDGQASPEQTPAMNIASAQLSPVAATADLQPEKTPQEAKAPVLTPQEDKPRTISPPLSPVEVKKILFAESQPESQRPAKKGQGPGYYNAVAFKQNMSLWDQKYGADGKFGFNLRGIERNKGPDNVTSDIPTVGLPRHSGKMKSGTSKDPDNYGSPYSEEMQESSSDSDMSSSVSADSDESASESGLSPATFSTRKRKRTRSNSGTSLALSQDKSTIRTGQETTAQRPEDSVFLGNFLSTFSDWSMAGYFSLAQNQVSPVLIRKDIQVQIAQLLVDQVTQSSLDHKIDGTLGLLDYADEVCPLETLQGDAALVSGMERLDLNSFVSLQDSNALSPSSSNGANPRQSSQRRETGKGTIVKLPPPHLRVRRGKDFLETLPPAISFWETFGLEPAHGQKDILAYCIHPHFAARAADTFLERLGLVYSGCNLGEHRRGESSNVFDRGLGSWNISPSADPRYSEVIQSLKTICGVLGSAFLSTPPSKDSNIVVYIVNPFTHAASLVDICAAFWSLFQQYIAEADKQQTRQLNELVLQIIPMDFVTSAESLVVPPQAEYLNLALEVYSRCPPKSSDVGPVNCAPPVLLAEPIPRSIGFKLSSEGSSPLQEGKHLHIACSRSLDQRWMSVAWSDNFGALQRNMSYCLRYRNSVAARPLPEVRGEVWKATRDIMDTIQTRWKVIIVSTDPVDQEEVDTWTNFADQYGKARSMTLDLVILGATTPPDLHLEPPYLPIPLSMFNQQPSSTPVATPNLGAGVSSPDQFGTAPTPPGGWGASANASTPTDALPEVESESLLTDIYDETWGVVLSHRLNSSLHQTEYRPALASGYLLRRKGSTDGDGLYTMSVNILFARRSPSSYDTLLREILGMYRDLATLARARGTRTVQQGTLPWHVATAIKAQTLLSYAL
Length1479
PositionKinase
OrganismAspergillus niger
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.08
Grand average of hydropathy-0.367
Instability index51.40
Isoelectric point5.01
Molecular weight160769.87
Publications
PubMed=26893421

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06575
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     558.92|     155|     165|     371|     533|       1
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  235-  368 (163.18/71.22)	.........................................PASIHDTPP..............GTDLWLSPSG..SIARlvAANPPQLNAGS.PYPSNVGG..SGN.....EKSSPATRKQwkvnvlwwlsNFGlpvDGIDDEAWVEVEVWEPFYSRLAGEvwRPSEEGASMLP.LKRILWPAIYCFRRTKSASSVF....YG
  371-  533 (248.09/129.27)	EGVS....SIAGDPlDF.....AEKWRVTEKLS.FAEASpkPPSVHQEAPTR.......DQDASSPDLLNLPEGIESLSR..ASQYPDLQTASLVYPTPPDG..AAA.....TGLNPMVTSD..........AFA...DDIEQSSTFMQQDRQNHHRQLSKE..RTGTDVISFGPsAGLVVGSGLYDTNDDDDLFGDInekdFG
  535-  624 (86.42/33.65)	KGITdadfSFFDDP.DFdrggvGEQAEAIQELSgFMDTD..EPEIQ...PTV.......DGQAS.PE..QTP..AMNIAS..AQLSPVAATADLQPEKTPQE..AKA.....PVLTP.......................................................................................
 1294- 1375 (61.23/20.87)	.........................................PPDLHLEPPYLpiplsmfNQQPSST.....PVATPNLGA..GVSSPD.QFGT..APTPPGGwgASAnastpTDALPEVESE..........SLL...TDIYDETW..........................................................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.44|      16|      16|     733|     748|       2
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  733-  748 (29.30/17.80)	SPYSEEMQESSSDSDM
  750-  765 (23.14/12.23)	SSVSADSDESASESGL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.17|      25|     169|     874|     903|       3
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   25-   50 (40.83/22.67)	YTDD..PGESPSNGYAILKHLSRLkDLE
  874-  900 (38.34/38.30)	YADEvcPLETLQGDAALVSGMERL.DLN
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     159.36|      51|     135|     780|     834|       4
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  780-  834 (80.34/56.49)	SNSGTSLALSQDKstiRTGQETTAQRPED..SVFLG.NFLSTF....SDWSMAGyFSLAQNQ
  916-  973 (79.02/44.33)	SNGANPRQSSQRR...ETGKGTIVKLPPPhlRVRRGkDFLETLppaiSFWETFG.LEPAHGQ
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.68|      16|      16|     694|     709|       7
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  694-  709 (29.38/15.74)	GIERNKGP.DNVTSDIP
  712-  728 (25.29/12.52)	GLPRHSGKmKSGTSKDP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.69|      11|      14|     633|     643|       8
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  633-  643 (19.73/10.63)	SPPLSPVEVKK
  649-  659 (19.96/10.86)	SQPESQRPAKK
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.39|      34|     523|     660|     693|       9
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  660-  693 (65.36/49.05)	GQGP...GYYNAVAFKQN.....MSL.WDQKYGA.DGKFGFNLR
 1176- 1219 (46.03/31.90)	GSSPlqeGKHLHIACSRSldqrwMSVaWSDNFGAlQRNMSYCLR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06575 with Med13 domain of Kingdom Fungi
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