<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06572

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTSSEQWGTFLQQCLLHRIDAAEFKNLTRLLMQRYPIGEAQLLDVLLETRLATGIKWDPLPPLYIDCLCKMGLVRTSTMLNSLLKHSSIHDKMPSAGGSEANAAAAAAVQGKQKRKCYTLMTDIRVVQDAMLSVSTGTASKTFAEALSIFASIVDWIQAVVAWHNSHLDTSHQTGGLMSSPDAVSLFESLGILLAALSGTAKGLEVLSADSHEALKIKLGQALSAYLPLCVEVSLPLRNRLDSLQKEFNLFGEPPSKALDVSMMENVNVNALQFEDSVMDGPVINSRAGLYVYINAMLVGRPLVDDSMLLNFLSNRYGGHYQVLIEELITASFDVLSNASYRNESSRTMFLFRSFLVNKLPTFIAAMLAASIVSLPLPMELCISHALSRLDPNTFPSFSQMFAMQSNTVLSDVRQEFLFACASHKLIPESSIERLLGENPMQTLPVGGPYNKDELVSQINANPERAEQLINEIESMEGNAGAIVGAITDVMHHLCNQKETMTLKNICNSLSRRPQALDVILLFRSLKQVLQPLCALLDAWHWDEDQGESQPVYDEFGSILLLVLTFKFRYDLRPQDMGIGGSNSFVLRLLENGFCSQKLDDLSEKQNKNLGSWINALFMAEGISEETMSACSPQEFYMLVTTLFNQSLSACEAGKLDFDTLKGGFEYLLEPFLLPSLILALNWLGNHIWESESDPSIPLKALHSLISPSSISGEAKEIHRTVLNITARSLEEQLKSIRSRQPDDTIKPILEALEPHLSFQRSGSTRRSELESWTAHTPGGLLASIRSTFQSLILWSTSPDMSMAPQSYTHRQFIAGIHIQGSMRVLCALIDELKLQATTSPTNTTGSSDLALDIAATMICAPLADSFAVDQNTYSPHHIDPTNTTKEIPPRNPILTPRGALYQLHDSVPKICEKDPLRAEIIVRLWRRVNAALTPPSQLDMNNIIQNMQLGVGVGGPGQMDLDTSGAGGHEEESTINQMLDNAVAAGMDGGGGAGGMGGMGSGGLDTSIDDVLNAADMAVGNPEFLDLDMEGLF
Length1034
PositionTail
OrganismAspergillus niger
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.06
Grand average of hydropathy-0.023
Instability index48.44
Isoelectric point4.99
Molecular weight113113.17
Publications
PubMed=26893421

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06572
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.40|      24|      34|     953|     985|       1
---------------------------------------------------------------------------
  953-  983 (35.98/34.01)	GVGGPGQMdldtsGAGGHeeESTINQMLDNA
  993- 1016 (43.42/18.44)	GAGGMGGM.....GSGGL..DTSIDDVLNAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.78|      30|      34|     809|     841|       2
---------------------------------------------------------------------------
  809-  841 (44.70/45.81)	THRQF...IAgIHIQGSMrvLCA.LIDELKL.QATTSP
  842-  876 (38.08/26.37)	TNTTGssdLA.LDIAATM..ICApLADSFAVdQNTYSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.33|      20|      35|     880|     901|       3
---------------------------------------------------------------------------
  880-  901 (34.30/28.10)	DPTNTtkEIPPR.....NPILTPRGAL
  915-  939 (30.04/17.73)	DPLRA..EIIVRlwrrvNAALTPPSQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.72|      17|      34|     358|     374|       4
---------------------------------------------------------------------------
  358-  374 (28.19/16.66)	NKLPTF..IAAMLAASIVS
  393-  411 (26.53/15.27)	NTFPSFsqMFAMQSNTVLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.70|      23|     302|     197|     230|       5
---------------------------------------------------------------------------
  197-  219 (34.06/34.88)	LSGTAKGLEVLSADSHEALKIKL
  241-  263 (37.64/14.75)	LDSLQKEFNLFGEPPSKALDVSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.47|      21|      35|     699|     719|       8
---------------------------------------------------------------------------
  699-  719 (34.93/24.76)	LKALHSLISPSSISG..EAKEIH
  734-  756 (32.54/22.52)	LKSIRSRQPDDTIKPilEALEPH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.63|      26|     138|     517|     551|      11
---------------------------------------------------------------------------
  526-  551 (49.32/35.64)	LKQVLQP..LCALLDAWHWDED...QGESQP
  665-  695 (37.31/12.95)	FEYLLEPflLPSLILALNWLGNhiwESESDP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06572 with Med5 domain of Kingdom Fungi
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