<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06567

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMNMERGRELVYKLVLNCASRRISPKQFTNFYNEFINARFDSVIDGNSEDKKAVAPIYESIARDLLKLLNDTDLNLVADYIVELLFVNYNTELVKPFLPRLHVVKNQMILNHLFSKATAFIGSLSNKLILEQLSGDVYTIIIPGVMKFNFSEMDKQLVVSISKFLNQVVQIPQSVGVTDASIKAKGVILLKRLCETDKLLYKRISGNLETKLQLKESSSSFPPPPSAMPSPSVTSPKYESNVTTTSKQPSSASHEAKYQDVKLVRYYKNLWLNNKIHYFSVTDPNFLDKYESIWALVNENGSPQPEKSLPAKVTDLIETTFTCFAQFVNNKLYHQSNSYFNLLERKWTVFITKQLPLIIKKYVPNGPQAVVQALENIDDKVVNAIKSYNTETDEVKNRTEDLFDDFPANNLDIRHEFLKNLIMLGLQPPTVLNEFLREDQMVDMKSLVTTEHPVIENSQGVKETITDMQKFITVSIDALDFESLFDESNQLATSCDNGLLKLAHSLENIAPTKQEEMSNIMYNILVQAVEAFDHKKVSKILSIFVLNVGHILTNIFCFMGADRFVRIVVKFIDVIWENNRNKPTDIMSDESEFENVHSFMSYSIATAFIIHVVKVYGINLETFVEVPSKSAILKFLSKLGDISDEFNPNQSESSTVLMKQWLRDLFVNNSISDPLMKSADVKELGTMIPFIFKQTMVNVESGVISEPSNFINGFEYFLQPFMSIGLINIVFWLEQYLITLRMNGLFTQVSGNIFELLSVIISPKSINPDAKVAHHVILKLNCIGLLKQLKFFQVPNESNYGIYSSRSQQDPKLENLISSLEAIAQSAYFYDLDPRITKPINNTYPQKQISYNKLVLTTDLPVNKLLTNQINSFWNLHSSTYYNFDYLIELVGLVTPLNFMENVFHTLKYKVATYGMPGSSNKPLPGAVDQVLSFFFYFMVLMDIRCPEDKTVLLEFIENGKLPNSFSESLPEANNMMVSNSINTQQYEPKTEQELLDPADEDFDMLFGESFSGMPEESQKGSELKAESSIMKDEQNETPVSNYSIARLTESFGYIYFTSMNLKKEAYDAGKVSEEEYETFKSQFNKYVEILKRSII
Length1095
PositionTail
OrganismEremothecium sinecaudum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Eremothecium.
Aromaticity0.11
Grand average of hydropathy-0.162
Instability index42.98
Isoelectric point5.26
Molecular weight124922.70
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06567
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     219.88|      73|     119|     580|     658|       1
---------------------------------------------------------------------------
  580-  658 (110.07/86.98)	NKPTDIMSDESEFEN.....VHSFMSYSIATafIIHVVKVYGINLE...TFVEVPSKsaILKFLSKLgdISDE.FNPNQSESSTVLMK
  697-  778 (109.81/68.91)	NVESGVISEPSNFINgfeyfLQPFMSIGLIN..IVFWLEQYLITLRmngLFTQVSGN..IFELLSVI..ISPKsINPDAKVAHHVILK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.61|      33|      71|     255|     289|       2
---------------------------------------------------------------------------
  255-  289 (51.77/36.79)	AKYQDVKLVRY...YKNLwLNNKIHYFsVTD..PNFLDKY
  324-  361 (50.84/26.87)	AQFVNNKLYHQsnsYFNL.LERKWTVF.ITKqlPLIIKKY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     215.71|      73|     305|     478|     557|       3
---------------------------------------------------------------------------
  478-  557 (113.97/85.66)	LDFESLFDESNQLATS....cDNGLLKLAHSLENIAptkqeeMSNIMYNI...LVQAV.EAFDHKKVS..KILSIFVLNVGHILTN.IFCF
  788-  872 (101.74/60.77)	LKFFQVPNESNYGIYSsrsqqDPKLENLISSLEAIA......QSAYFYDLdprITKPInNTYPQKQISynKLVLTTDLPVNKLLTNqINSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.53|      42|     530|     416|     457|       4
---------------------------------------------------------------------------
  416-  457 (71.87/51.18)	FLKNLIMLGLQPP...TVLNEFLREDQMVD..MKSLVTTEHPVIENS
  934-  980 (64.66/45.21)	FFYFMVLMDIRCPedkTVLLEFIENGKLPNsfSESLPEANNMMVSNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.22|      21|     804|      78|     104|       5
---------------------------------------------------------------------------
   78-  104 (31.29/31.54)	DYIVELLfvnyntELVKP..FLPR.LHVVK
  884-  907 (29.93/16.06)	DYLIELV......GLVTPlnFMENvFHTLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.15|      14|      72|     125|     138|       6
---------------------------------------------------------------------------
  105-  118 (23.52/14.09)	NQMILNHLFSKATA
  125-  138 (22.63/13.29)	NKLILEQLSGDVYT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06567 with Med5 domain of Kingdom Fungi
Unable to open file!