<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06566

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMNTSGCVSCSKLGLIAYGDSSSTNSNLCITFLETVNGINWRFHPPKQYSIHNQLHEEQNSNSNKKGVNLFYDLRSVHWNNWSLLNGELLAVCDDLGNMTMLTAGQTRDGNGTYHKMTVLFQDNVYKIHNQIIPLDTVSKKEGSLKVDRKHTKKEYGSTILDFQWIGNQKPEIAQIKAQRDPMTNTFESQMQQCPPSGVFHPASVKNACIAIRRNGHTDLWYQFSNTLDYKKISLQLTKNKESEWLRHARIAHMDVEQSFLVGMYSNISKCFSYYELQVDWNLSHKDPSMVLDPKLNLKHIFRANPDTMGPNGELLKLENFHIISKKALQGSRPEILISYNILGTTKTLVRRFEMIKTTPNMVFLSSFGVNISNANGSSKLSRYTLKHVQDLVFEHKVLDIQPHALDSLVAFRLQNGEMHFYNRYTWKLEEDSEASSVPYTKDSIFSIFATGFVFPNIPPIDAVEWCINSPSSGGVIVKLKQNKGPQFLTLKTKVTEDPSKDTIHATAFAFEFFRFNNRLHSGEDLVIAIKTHILKLQQIDANRAVDFIFIIISTILKLYGIQFEGPKEVLDKLLQSKAIQKLLLLQMELGSHLQNRTVFSMAYAAMKLRSIKLAMNGVARNVHAMIQHTALVNSLPNGKGFQFAFSKQDLIYSLIPSINWFVTFVTFLTQQLILLVNNPADKTHSLVIGIFSSITTRQLMLKLVMELKNLIGLITKFPETNYTILNESSNFLRKALGDSPVNLEKFETFLTDVNSKFASLADQDVTANTKREPYFLVKADIPPDIAHMKEFLLSYASTAMLSYINLAEVFFASTGTLRIFDSERFNPKISGLLQPLSAGLVVDDEALPNSVKESRAFSPLDYDDISSEWVDMSTIPCIKRCTRCGCITRAGNVVDTKHTVLETAIVTKRWTALYSRYCQCTGLLYELELDTSD
Length933
PositionTail
OrganismEremothecium sinecaudum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Eremothecium.
Aromaticity0.10
Grand average of hydropathy-0.174
Instability index34.94
Isoelectric point8.57
Molecular weight105647.20
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06566
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.68|      42|     369|     223|     296|       8
---------------------------------------------------------------------------
  223-  273 (59.67/56.74)	FSntLDYKKI...SLQLTKNKEsewlrhARIAHMDVEQSFLVGMYSNiSKCFSY
  599-  643 (68.00/ 7.00)	FS..MAYAAMklrSIKLAMNGV......ARNVHAMIQHTALVNSLPN.GKGFQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.54|      20|     716|      16|      36|       9
---------------------------------------------------------------------------
   16-   36 (32.55/27.60)	AYGDsSSTNSNLCITFLETVN
  735-  754 (35.98/25.21)	ALGD.SPVNLEKFETFLTDVN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.68|      14|     745|     106|     119|      10
---------------------------------------------------------------------------
  106-  119 (27.46/16.53)	TRDGNGTYHKMTVL
  888-  901 (25.21/14.66)	TRAGNVVDTKHTVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.40|      14|     209|     644|     660|      14
---------------------------------------------------------------------------
  644-  660 (19.61/21.29)	AFSKQDliYSLIPSiNW
  856-  869 (28.79/17.23)	AFSPLD..YDDISS.EW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06566 with Med16 domain of Kingdom Fungi
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