<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06537

Description Mediator of RNA polymerase II transcription subunit 31
SequenceMMMKGNIVIPFITGGIFGIIFRALGRVLVDLLSHLGPKPNSSEQNLHRRRHDGETHDADRWWIIRRRLLSRTVTSVSCSPNIKWCSTAWLLVKKPMTPQIIKAHFRPKKVYKDPDDGRQRFLLELEFVQCLANPTYIHYLAQNRYFEDEAFIGYLKYLQYWQRPEYIKYIMYPHCIYFLELLQNASFRNAMAHPANKELTHRQQFYYWKNYRNNRLKHMLPRPLPETTAAPPSNALPPPIPPSTSTITAASAPGSAPPVHSPMQYGVPSGPPLAKNDPRSGIDRRKRKKDG
Length291
PositionMiddle
OrganismCynara cardunculus var. scolymus (Globe artichoke) (Cynara scolymus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> campanulids> Asterales> Asteraceae> Carduoideae> Cardueae> Carduinae> Cynara.
Aromaticity0.11
Grand average of hydropathy-0.547
Instability index51.59
Isoelectric point9.98
Molecular weight33732.69
Publications
PubMed=26786968

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription, DNA-templated	GO:0006355	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06537
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.97|      20|      27|     121|     140|       1
---------------------------------------------------------------------------
  121-  140 (37.17/23.43)	FLLELEFVQCLANPTYIHYL
  151-  170 (39.81/25.56)	FIGYLKYLQYWQRPEYIKYI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.53|      17|      17|     221|     237|       2
---------------------------------------------------------------------------
  221-  237 (31.79/17.63)	PRPLPETTAAPPSNALP
  241-  257 (28.74/15.27)	PPSTSTITAASAPGSAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.54|      14|      15|     187|     201|       3
---------------------------------------------------------------------------
  187-  201 (21.15/14.75)	FRNAMAHPANKeLTH
  205-  218 (28.38/15.66)	FYYWKNYRNNR.LKH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06537 with Med31 domain of Kingdom Viridiplantae
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