<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06511

Description "Mediator complex, subunit Med12"
SequenceMSFKVYPAIAFSSLIETPSLSNPNNVSSFKNQQRVLDFMMQNMSGEMQRYHATNCTSAVNNSAVGGSLGRDTSRAESSALPANFPLNRRPSQLAPYKLRCEKDPLNSRLPPPDFHPPTTNCPEETLTKDYVLGGYRETVEGLEESREITLSQIPTFTKPVIIKCKEAIRKYHRAINESRAQKRKAGQVYGVPLAGNLLSKSGVFPEQKATGEDFRKKWIEGLSQQHKRLRSLADHVPQGYRRKSPFEVLIRNNVPLLRATWFIKVTYLNLVQAISLVSSWVRPGSSSTSSGSLDKTRFSRSDQWTKDVIEYLQYLLDEFVSKNNSHSTMHSKDRSPQFAYAGSMQHKSDSVMALVDGEEPSLHFKWWYVVRIIQWHHAEGLLLPSLIIDWVIFKALFNHKDLDIRSWIKQMLMPLHRALLKNIEKELLGILQLLLPIIYGVIETIVLSQNYVRTLVGIAVRFIQEPSPGGSDLVDNSRRAYTISAMVEILRYLILAVPDTFVALNCFPLPSCVVSSAANDGSLITRVSGEGGKLKGGSLEAACMLNDKGLEVQGRSLSIDSVVSSIQKCAVNLARAASPGHPGHNVAKAANELDRALIHGDITIAYKCMFEDFCDEAVDKRWIAEVSSYLRSSLKWLGAMRSSFVCSIFFVCEWATCDFRDFRTSPPHGVKFSGKRDFSQIYVATRLLEMKMRNMRSSRKSGRTSAVDVSMKHHGLANNIEVESKSKVAHKKIKDLSQFFQSPGPLHDIIVCWLDQHQTQNGEGFKRVQLLITELIRSGIFYPQAYVRELIVSGIMGKNDSMVDMDRRRRHYKLLKHLPGPYIQDALEEAQIAEVSLISEAMHIYSNERRLLLHELLDHPKNIIIANSSLQKQKNHQKFGKDGSLAPSRDQWKIPSPASDSLSSKNVNRTSKLEELMTSISVLLHFPNSNSTTAGNGFDESQAVKRPIGPMVIRSDPGEGTPGCEECRRAKRQKVIEEKSPYLQGQSLNLSDDEDIWWVRKGLKSLESFRADPPIKPVKQASRGRQKIVRKTQSLAQLAAARIEGSQGASTSHVCDSRVSCPHHRNGSDNDVPKTTDSVKTSHSGDISSIGKILKRMPLDEKRAIVVWLMGIVKQLVDEAGKITETVPKVGQYGRSFPPVDDRGLARWKLGEDELSTILYLMDVCDDLVNAARFLVWLLPKVPINPIPTVHGGRNVMIVPRNVENQLCAVAEAYILSSLRRYENILAAADLIPETLSAMMHRASVVMASNGRVSGSAALVFSRQMLKKYGHVVSVVEWVKNFKSTSDKRLVMELESGRSSDGEFGFPLGVPAGVQDFDEFLRQKISGVRISRVGLGMRDTVQRLVDEAIPSFYGQDKKSFAGGSMKRGTVEKSDDGYQIAQQVVKGLLDCMRQTGGAAQEGDPTLVAFAVSAIVSNVGQVIAKIPDITANTTASSLNFAKQILRIHLTSLSLLKDALGERQSRVFEIALATEASSALAQVFSPAKASRGQLQLSPESRDSNAIDNPNSAGKTTFSKAAKTTGAISALVVGAVLQGIASLERMVTVFRLKEGLNVIQYVRSTRSNSNGNVRSIGDLKMDSLVEVSVHWFRVLVGNCRSVSEGFIVELLGESSIVALSRIQRMLPINLVFPPAFAIFGFLVWRRFILNASVVPRDNIPQLFQSLTLAIGDAIKHLPFRDVCLRECATLYDIVAADSTDSEFAMMLDLNGPDPHSKLTAFVPLRARIFLNAIIDCQLPLEIVNQDDGNWASGHSELKALHVENETKLLDKLVHILDTLQPAKFHWQWVELRLLLNEQAVIEKVDSRDISLAEALRSFSPNNDNGGTSENENNFIQMVLTRLLGIKRKFEMASLEEGEVVDDGTDSKRHSRTFTPVSDVEAFIVGQQHVTEKALVELLLPCIDQSSDDSRITFASDLIKQMNEIEQQISTVTHGGAKQAGTVASGIEGPVSKVNTRKGMRGGSPGLARRPATPVELMLPSPSALRASMESSVRNMRHMLASVVLRLLGSRVVNEDADLSNPASRFSVKREVESMIESSATVDLGESLFDRLLLVLHALLSSSQPYWLRSKFPSKSTAEGTRDSTLYDREVAESLQNELDGMQLPDTIRWRIQTAMPFVFPSVRFSISCQPPSVPLSAISSLQPPTISVPGPHLRSNPSRTTSNGPGKATKPVFSSQPDSDMEIDPWTLLEDGAGSGPSSINAAAIAGSDHANLKASSWLKGAVRVRRMDLTYIGAIDDDS
Length2236
PositionKinase
OrganismCynara cardunculus var. scolymus (Globe artichoke) (Cynara scolymus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> campanulids> Asterales> Asteraceae> Carduoideae> Cardueae> Carduinae> Cynara.
Aromaticity0.07
Grand average of hydropathy-0.223
Instability index48.90
Isoelectric point8.93
Molecular weight247283.14
Publications
PubMed=26786968

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of development, heterochronic	GO:0040034	IEA:EnsemblPlants
regulation of radial pattern formation	GO:0090213	IEA:EnsemblPlants
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06511
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     429.85|     138|     170|    1014|    1180|       1
---------------------------------------------------------------------------
  958- 1113 (211.80/123.11)	GEGTPGCEECRRAKRQKVIEEKSP..YLqgqsLNLSDD....ED..IWWVRkglkslesfradpPIKPVKQASRGRQKIV..RKTQS.LAQLAAARIEGS.....QGASTSHVCDSRVSCPHHRNGSDNDVPKTTDSVKTSHSGDIS.SIGKILKRMPLdEKRAIVVWLMGIV
 1134- 1279 (176.38/144.57)	GRSFPPVDDRGLARWKLGEDELSTilYL....MDVCDDlvnaARflVWLLP...........kvPINPIPTVHGGRNVMIvpRNVENqLCAVAEAYILSSlrryeNILAAADLIPETLSAMMHRAS....V......VMASN.GRVSgSAALVFSRQML.KKYGHVVSVVEWV
 1988- 2041 (41.67/11.04)	...............................................................................V..RNMRH.MLASVVLRLLGS.....RVVNE....DADLSNPASRFSVKREVESMIESSATVDLGE............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     168.17|      54|     170|     262|     316|       2
---------------------------------------------------------------------------
  262-  316 (86.80/55.20)	FIKVTYlNLVQAISLVSSWVRPGSS.......STSSGSLDKTRFSRSDQWTKDVIEYLQYLL
  434-  494 (81.37/47.48)	LLPIIY.GVIETIVLSQNYVRTLVGiavrfiqEPSPGGSDLVDNSRRAYTISAMVEILRYLI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06511 with Med12 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IEQQISTVTHGGAKQAGTVASGIEGPVSKVNTRKGMRGGSPGLARRPATPV
2) ISVPGPHLRSNPSRTTSNGPGKATKPVFSSQP
3) NHQKFGKDGSLAPSRDQWKIPSPASDSLSSKNVNRT
4) STTAGNGFDESQAVKRPIGPMVIRSDPGEGTPGCEECRRAK
5) TSHVCDSRVSCPHHRNGSDNDVPKTTDSVKT
1920
2142
875
931
1051
1970
2173
910
971
1081










Molecular Recognition Features






MoRF SequenceStartStop




NANANA