<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06506

Description "DNA helicase, ATP-dependent, RecQ type"
SequenceMSEWPTPAQDITANWHQGLNIMFLALIYRTGELTCRNNFGGASKHVDKFTRDNWSQHAKAHDNFSNQDKLLKSNFLFSLSTQKPSVEAAMSAAVRSLSCQFQNVTNPPSPHVDKAWQALSNLKLSSRNYIKPGKSRPLANDGGTASFQDVRRATQQCSSNVNNTILRQTGAECSNEINIQHSESRDMTNRFATVATSVAEAGRFGMMRGGGYTSNSIDAGRRNTNCSYSNTTNLGQGIHNYATNASHFNGFQETSVGGIDDDDDDILQNLDVDQIVTQHYQSACTPKSSTLKFQPITPAVCNSAARHDDLSLPPELCVDCSHGCKARLCPEASNHLQIMKDMLISISNDLLDNVDLNSDQIQKLRQDRLMLNKQIQQLEKHLQSRPVDEKRSTSNFGAYTASRAFQYETPPTFASRVDPTRLDQFYMHNETDGPNRWNSSSVSYSSVGNVSVSSAPMEREAYVPKYVEVNYIEGSDDKNWSKRDFPWTKKLEANNKKVFGNHFFRPNQREIINATMSGNDVFVLMPTGGGKSLTYQLPALICPGITLVISPLVSLIQDQIMHLLQANIPAAYLSANMEWTEQQEILRELCSEYCNYKLLYVTPEKVARSDALLRQLENLHARELLDRIVIDEAHCVSQWGHDFRPDYQGLGILKQKFPKVPVLALTATATTSVKEDVVQALGLVDCIIFRQSFNRSNLRFSVIPKTKKCMEDINKFIKDNHFDECGIIYCLSRMDCEKVAEKLQEYGHKAAFYHGSMDPDLRASVQKQWSKDEINIICATVAFGMGINKPDVRFVIHHSLPKSIEGYHQECGRAGRDGQNSSCVLYYSYGDYIRVKHMLSNGAVEQSSFASGQPRAGTTNSGRMLETNTENLLRMVSYCENDVDCRRFLQLVHFGEKFDSSNCRKTCDNCSNTQALVDKDVSEIAKQLVELVKSVQQQFSASHILDVYCLNLQVELVKSVRQQFSASHILDVYKGSMSQIVKRNKHDTLRLHGAGKNVAKGEASRVLRHLVVEEVLVEDVKKSDLYGSVSSILKVNEKKAGNLLAGRQTIILRFPSASKTPKSYRNDATPARGSLTSSKQSPVPVDAPAQPQSEVDLELSAKLFIALRMLRTLLLKEAADGVNAYHIFGGKVSKYGDRVLQTIEATINEHYKIDKNSSSGNSADSVKRRRGTVNTPYEDSRDEDDFIASTARSKKRVVEKSNPSIDSVDFFYDITDEDLDSYDIEANTSNPNANQNNGRVLPSW
Length1244
PositionUnknown
OrganismCynara cardunculus var. scolymus (Globe artichoke) (Cynara scolymus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> campanulids> Asterales> Asteraceae> Carduoideae> Cardueae> Carduinae> Cynara.
Aromaticity0.07
Grand average of hydropathy-0.508
Instability index45.66
Isoelectric point7.34
Molecular weight139166.91
Publications
PubMed=26786968

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
3'-5' DNA helicase activity	GO:0043138	IEA:InterPro
ATP binding	GO:0005524	IEA:UniProtKB-KW
nucleic acid binding	GO:0003676	IEA:InterPro

GO - Biological Process
DNA recombination	GO:0006310	IEA:InterPro
DNA repair	GO:0006281	IEA:InterPro
DNA replication	GO:0006260	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06506
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.61|      20|      24|     929|     952|       1
---------------------------------------------------------------------------
  929-  948 (40.33/41.34)	VELVKSVQQQFSASHILDVY
  954-  973 (40.27/26.98)	VELVKSVRQQFSASHILDVY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.29|      23|      25|    1146|    1169|       2
---------------------------------------------------------------------------
 1146- 1169 (35.35/26.03)	TINEHYK..IDKNSSSGNSADSvKRR
 1172- 1196 (34.94/20.86)	TVNTPYEdsRDEDDFIASTARS.KKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.65|      23|      25|      84|     107|       3
---------------------------------------------------------------------------
   84-  107 (35.65/31.44)	PSVEAAMSaAVRSLSCQFQNVTNP
  110-  132 (41.00/30.92)	PHVDKAWQ.ALSNLKLSSRNYIKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.77|      21|      28|     751|     771|       4
---------------------------------------------------------------------------
  751-  771 (39.67/29.75)	AFYHGSMDPDLRASVQKQWSK
  782-  802 (39.10/29.20)	AFGMGINKPDVRFVIHHSLPK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.81|      19|      25|     301|     321|       5
---------------------------------------------------------------------------
  301-  321 (30.94/28.03)	CNSAARHddLSLPPELCVDCS
  329-  347 (33.87/22.65)	CPEASNH..LQIMKDMLISIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.95|      33|     216|     486|     521|       6
---------------------------------------------------------------------------
  486-  521 (56.07/49.26)	PWTKK.LEANNKKVFGNHFfrpNQREIIN..ATMSGNDV
  704-  739 (53.88/37.33)	PKTKKcMEDINKFIKDNHF...DECGIIYclSRMDCEKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.82|      16|      24|     877|     892|       7
---------------------------------------------------------------------------
  877-  892 (30.54/22.24)	SYCENDVD.CRRFLQLV
  901-  917 (26.27/17.88)	SNCRKTCDnCSNTQALV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.81|      21|      29|    1040|    1063|       8
---------------------------------------------------------------------------
 1040- 1063 (30.97/33.14)	A....GNLLAGRQTIIlrfP.SASKTPKS
 1068- 1093 (27.84/19.02)	AtparGSLTSSKQSPV...PvDAPAQPQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.08|      16|      25|     996|    1014|       9
---------------------------------------------------------------------------
  996- 1014 (20.15/20.32)	KNVAKGEASRVLRhlvVEE
 1022- 1037 (25.93/15.92)	KSDLYGSVSSILK...VNE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      22.98|       8|      27|    1108|    1118|      11
---------------------------------------------------------------------------
 1108- 1118 ( 9.18/13.67)	RMLRTLllkEA
 1138- 1145 (13.80/ 7.96)	RVLQTI...EA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06506 with Med34 domain of Kingdom Viridiplantae
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