<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06506

Description "DNA helicase, ATP-dependent, RecQ type"
SequenceMSEWPTPAQDITANWHQGLNIMFLALIYRTGELTCRNNFGGASKHVDKFTRDNWSQHAKAHDNFSNQDKLLKSNFLFSLSTQKPSVEAAMSAAVRSLSCQFQNVTNPPSPHVDKAWQALSNLKLSSRNYIKPGKSRPLANDGGTASFQDVRRATQQCSSNVNNTILRQTGAECSNEINIQHSESRDMTNRFATVATSVAEAGRFGMMRGGGYTSNSIDAGRRNTNCSYSNTTNLGQGIHNYATNASHFNGFQETSVGGIDDDDDDILQNLDVDQIVTQHYQSACTPKSSTLKFQPITPAVCNSAARHDDLSLPPELCVDCSHGCKARLCPEASNHLQIMKDMLISISNDLLDNVDLNSDQIQKLRQDRLMLNKQIQQLEKHLQSRPVDEKRSTSNFGAYTASRAFQYETPPTFASRVDPTRLDQFYMHNETDGPNRWNSSSVSYSSVGNVSVSSAPMEREAYVPKYVEVNYIEGSDDKNWSKRDFPWTKKLEANNKKVFGNHFFRPNQREIINATMSGNDVFVLMPTGGGKSLTYQLPALICPGITLVISPLVSLIQDQIMHLLQANIPAAYLSANMEWTEQQEILRELCSEYCNYKLLYVTPEKVARSDALLRQLENLHARELLDRIVIDEAHCVSQWGHDFRPDYQGLGILKQKFPKVPVLALTATATTSVKEDVVQALGLVDCIIFRQSFNRSNLRFSVIPKTKKCMEDINKFIKDNHFDECGIIYCLSRMDCEKVAEKLQEYGHKAAFYHGSMDPDLRASVQKQWSKDEINIICATVAFGMGINKPDVRFVIHHSLPKSIEGYHQECGRAGRDGQNSSCVLYYSYGDYIRVKHMLSNGAVEQSSFASGQPRAGTTNSGRMLETNTENLLRMVSYCENDVDCRRFLQLVHFGEKFDSSNCRKTCDNCSNTQALVDKDVSEIAKQLVELVKSVQQQFSASHILDVYCLNLQVELVKSVRQQFSASHILDVYKGSMSQIVKRNKHDTLRLHGAGKNVAKGEASRVLRHLVVEEVLVEDVKKSDLYGSVSSILKVNEKKAGNLLAGRQTIILRFPSASKTPKSYRNDATPARGSLTSSKQSPVPVDAPAQPQSEVDLELSAKLFIALRMLRTLLLKEAADGVNAYHIFGGKVSKYGDRVLQTIEATINEHYKIDKNSSSGNSADSVKRRRGTVNTPYEDSRDEDDFIASTARSKKRVVEKSNPSIDSVDFFYDITDEDLDSYDIEANTSNPNANQNNGRVLPSW
Length1244
PositionUnknown
OrganismCynara cardunculus var. scolymus (Globe artichoke) (Cynara scolymus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> campanulids> Asterales> Asteraceae> Carduoideae> Cardueae> Carduinae> Cynara.
Aromaticity0.07
Grand average of hydropathy-0.508
Instability index45.66
Isoelectric point7.34
Molecular weight139166.91
Publications
PubMed=26786968

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
3'-5' DNA helicase activity	GO:0043138	IEA:InterPro
ATP binding	GO:0005524	IEA:UniProtKB-KW
nucleic acid binding	GO:0003676	IEA:InterPro

GO - Biological Process
DNA recombination	GO:0006310	IEA:InterPro
DNA repair	GO:0006281	IEA:InterPro
DNA replication	GO:0006260	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06506
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.61|      20|      24|     929|     952|       1
---------------------------------------------------------------------------
  929-  948 (40.33/41.34)	VELVKSVQQQFSASHILDVY
  954-  973 (40.27/26.98)	VELVKSVRQQFSASHILDVY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.29|      23|      25|    1146|    1169|       2
---------------------------------------------------------------------------
 1146- 1169 (35.35/26.03)	TINEHYK..IDKNSSSGNSADSvKRR
 1172- 1196 (34.94/20.86)	TVNTPYEdsRDEDDFIASTARS.KKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.65|      23|      25|      84|     107|       3
---------------------------------------------------------------------------
   84-  107 (35.65/31.44)	PSVEAAMSaAVRSLSCQFQNVTNP
  110-  132 (41.00/30.92)	PHVDKAWQ.ALSNLKLSSRNYIKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.77|      21|      28|     751|     771|       4
---------------------------------------------------------------------------
  751-  771 (39.67/29.75)	AFYHGSMDPDLRASVQKQWSK
  782-  802 (39.10/29.20)	AFGMGINKPDVRFVIHHSLPK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.81|      19|      25|     301|     321|       5
---------------------------------------------------------------------------
  301-  321 (30.94/28.03)	CNSAARHddLSLPPELCVDCS
  329-  347 (33.87/22.65)	CPEASNH..LQIMKDMLISIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.95|      33|     216|     486|     521|       6
---------------------------------------------------------------------------
  486-  521 (56.07/49.26)	PWTKK.LEANNKKVFGNHFfrpNQREIIN..ATMSGNDV
  704-  739 (53.88/37.33)	PKTKKcMEDINKFIKDNHF...DECGIIYclSRMDCEKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.82|      16|      24|     877|     892|       7
---------------------------------------------------------------------------
  877-  892 (30.54/22.24)	SYCENDVD.CRRFLQLV
  901-  917 (26.27/17.88)	SNCRKTCDnCSNTQALV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.81|      21|      29|    1040|    1063|       8
---------------------------------------------------------------------------
 1040- 1063 (30.97/33.14)	A....GNLLAGRQTIIlrfP.SASKTPKS
 1068- 1093 (27.84/19.02)	AtparGSLTSSKQSPV...PvDAPAQPQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.08|      16|      25|     996|    1014|       9
---------------------------------------------------------------------------
  996- 1014 (20.15/20.32)	KNVAKGEASRVLRhlvVEE
 1022- 1037 (25.93/15.92)	KSDLYGSVSSILK...VNE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      22.98|       8|      27|    1108|    1118|      11
---------------------------------------------------------------------------
 1108- 1118 ( 9.18/13.67)	RMLRTLllkEA
 1138- 1145 (13.80/ 7.96)	RVLQTI...EA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06506 with Med34 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HYKIDKNSSSGNSADSVKRRRGTVNTPYEDSRDEDDF
2) KSYRNDATPARGSLTSSKQSPVPVDAPAQPQ
1150
1062
1186
1092










Molecular Recognition Features






MoRF SequenceStartStop




1) VDFFYDIT
1208
1215