Description | Mediator of RNA polymerase II transcription subunit 31 |
Sequence | MEDRPTLTNPRFTLELEFVSSLANPYYLSHLAVTYPNLLGISRADDDDDSSSPDAEAFAAYLAYLYSYWKTPEYSQFLTHPGPTLRALRLLQEDTFRRDIILPQVIEGLAGVSVPEPAQAEMDTADEKQPDGQNGKT |
Length | 137 |
Position | Middle |
Organism | Penicillium freii |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium. |
Aromaticity | 0.10 |
Grand average of hydropathy | -0.472 |
Instability index | 44.40 |
Isoelectric point | 4.32 |
Molecular weight | 15342.82 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 ARBA:ARBA00003669 ECO:0000256 RuleBase:RU364129 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription, DNA-templated GO:0006355 IEA:InterPro |
Binary Interactions |
Repeats | >MDP06501 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 155.93| 49| 76| 5| 56| 1 --------------------------------------------------------------------------- 5- 56 (80.96/60.88) PTLTNPRFTLELEFVSSLANPYYLSHLA.VTYPNllgISRAD.DDDDSSSPDAE 83- 133 (74.97/48.74) PTLRALRLLQEDTFRRDIILPQVIEGLAgVSVPE...PAQAEmDTADEKQPDGQ --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DTADEKQ 2) VTYPNLLGISRADDDDDSSSPDAEAFAAYLAYLYSYWKTPEYSQFLTH | 123 33 | 129 80 |
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