<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06499

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDRTHPTSFQARPPSPSSPAGSLKENPRLPISSEHIPQTPTSPPLMSVNEQSHAANFTSSHTSPNQATVQPPNISSPPSSAPMSTQVSQQPTMSTTNSFPTPASSVSSHPANATSEDVDQGRKPFNMGIQVSAENSGAAPAQQQTKQPTQHRPTDHDRQTLQTESTNDFATGQGQHSTDPDAMDVDTEPTRRADTLSLDLDSLQKELTSAFHLCKSSPIVTGPDPSVDLVSLYGLGSIAHSVARMDPVTGEKINRLRKSYEGKLKGLGLAGRNKPHKQEIGAPGSLRHMTLWPEEEWQNQKVHGKAIKVSDMDSALQNLQSRAMQMEPGPIPNNDWWEDILGHEKQAKNPAPGETGKKAAPAPTAGRPSMQSYAASPRSQEAERPRPSRGRKRNYDDNSFAGYGEGFVDDDDDPGFYSNGEGTGKKKRKKDHVAKVSTPMSERSASYGVGMFGIGAR
Length458
PositionHead
OrganismPenicillium freii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.05
Grand average of hydropathy-0.950
Instability index55.56
Isoelectric point6.74
Molecular weight49393.82
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP06499
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     107.21|      25|      27|      14|      39|       1
---------------------------------------------------------------------------
   14-   37 (32.88/17.40)	.......PP....SP..........SSPAGSLKENPrLPISSEHI
   38-   63 (23.27/ 7.23)	P.QtptsPPlmsvNE..........QSHAANF........TSSHT
   65-   88 (28.28/10.44)	PnQatvqPP....NI..........SSPPSS......APMSTQ.V
  120-  153 (22.78/ 6.92)	D.Q.grkPF....NMgiqvsaensgAAPAQQQTKQP.....TQHR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.83|      11|      15|     397|     407|       2
---------------------------------------------------------------------------
  397-  407 (22.39/11.07)	DDNSFAGYGEG
  413-  423 (23.44/11.87)	DDPGFYSNGEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.27|      17|      21|     352|     368|       3
---------------------------------------------------------------------------
  352-  368 (29.78/14.69)	APGETGKKAAPAPTAGR
  376-  392 (30.49/15.22)	ASPRSQEAERPRPSRGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.87|      25|      26|     198|     223|       4
---------------------------------------------------------------------------
  158-  180 (31.66/24.25)	..DRQTLQTESTNDFATGQGQH.STD
  198-  223 (37.82/36.96)	SLDLDSLQKELTSAFHLCKSSPiVTG
  227-  251 (39.39/32.31)	SVDLVSLYGLGSIAHSVARMDP.VTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.28|      20|      21|     263|     282|       5
---------------------------------------------------------------------------
  263-  282 (34.29/22.68)	GKLKGLGLAGRNKPHKQEI.G
  285-  305 (34.00/22.43)	GSLRHMTLWPEEEWQNQKVhG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06499 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LKGLGLAGRNKPHKQEIGAPGSLRHMTLWPEEEWQNQKVHGKAIKVSDMDSALQNLQSRAMQMEPGPIPNNDWWEDILGHEKQAKNPAPGETGKKAAPAPTAGRPSMQSYAASPRSQEAERPRPSRGRKRNYDDNSFAGYGEGFVDDDDDPGFYSNGEGTGKKKRKKDHVAKVSTPMSERSASYGVGMF
2) MSDRTHPTSFQARPPSPSSPAGSLKENPRLPISSEHIPQTPTSPPLMSVNEQSHAANFTSSHTSPNQATVQPPNISSPPSSAPMSTQVSQQPTMSTTNSFPTPASSVSSHPANATSEDVDQGRKPFNMGIQVSAENSGAAPAQQQTKQPTQHRPTDHDRQTLQTESTNDFATGQGQHSTDPDAMDVDTEPTRRADTLSLDLD
265
1
453
202










Molecular Recognition Features






MoRF SequenceStartStop




1) DDPGFYS
2) DWWEDILGHE
3) KKKRKKDHVAKVST
4) YGEGFVD
413
336
426
404
419
345
439
410