<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06498

Description Mediator of RNA polymerase II transcription subunit 6
SequenceMASQDASMEEILWRSPPHVQMMGGFLHSNNILFYFAESPFFDSTSNNASLAIQANYNDAFRHFVETREAFEARLKTMQGLEFIVSYDPLQAAAQTDNRFAHEPSNIWVIRKQNRRKRSGMDDEVTVISTYFIVGDCIYMAPSVASVVGNRILSAVTSLTQLMKSAATLPTFTASHGHTYLPPGVRSKEGAGTSQASQSKEATPMPDVSFPTTESSQATSKSSLGGSTTSSNYQDTRSLAESFSLLTRYGDEFMDESPLVGEPGSFILSRTGGETTGSAVKGAPRIAANAAQTSTPSALPVRASTPQVRVDTPGKASEKSSPPSSTGDRGKKKKSRIVS
Length338
PositionHead
OrganismPenicillium freii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.08
Grand average of hydropathy-0.412
Instability index51.80
Isoelectric point7.84
Molecular weight36405.17
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. 


ECO:0000256	PIRNR:PIRNR013286

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06498
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     139.15|      33|      33|     191|     223|       1
---------------------------------------------------------------------------
  191-  223 (51.81/25.49)	GTSQASQSKEATPMPD.VSFPTTESSQATSKSSL
  225-  258 (43.75/20.51)	GSTTSSNYQDTRSLAEsFSLLTRYGDEFMDESPL
  293-  324 (43.58/20.40)	STPSALPVRASTPQVR.VDTPGKASEKSSPPSS.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.53|      11|      39|     138|     148|       2
---------------------------------------------------------------------------
  138-  148 (20.07/10.11)	YMAPSVASVVG
  179-  189 (21.47/11.23)	YLPPGVRSKEG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06498 with Med6 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DEFMDESPLVGEPGSFILSRTGGETTGSAVKGAPRIAANAAQTSTPSALPVRASTPQVRVDTPGKASEKSSPPSSTGDRGKKKKSRIVS
2) HTYLPPGVRSKEGAGTSQASQSKEATPMPDVSFPTTESSQATSKSSLGGSTTSSNYQDTR
250
177
338
236










Molecular Recognition Features






MoRF SequenceStartStop




1) FSLLTRYG
2) KSSPPSSTGDRGKKKKSRIVS
242
318
249
338