<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06487

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMIPHSSAGVQPWGRSLRALNNGSGRVDASQTLVQSDPQLEKLSMSMPQPLPRQPAVIDLTANTSDSQDREPPAKRLKLDAPPGSCPPEGSPAPGSGEARSTPGTGSSKPNPLAWRGRPVWSFQALISETTGAVEAKEDDTNPQGKTPASPPPLPLIPWKPAPQEASGSNSAKPADVASTKEVQTTPYRIVVPPVAPKLKGERVADFSPWTGNHPEDTLNDHTAKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFAAALEKRQSHSTIATPSSFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGIRGKVLLDQCLGKGIPVPRAIWLARCVGANEIRAFKRKGTSGTLALGLETKWVRDWTSTVQQFLESVIGTCGSSDWKMKMTYAVSLTSRLFFERLLDHDQYLSWFLVSLEAAPLNTVPVWLLMLGIYWNNIMRYRKRGRRLAEVLLEKLRLIKQPGQSTALEPLVDRLSRCIRRLVLEHTSSVILPASWDKYKDLIASCLNLKELPDKTTLQNLAERNVRVQLPTNHQGTTQQLPQQHVIHLFDSIRSAHDVLSTSSACLNAVEDKATLVAKLLEWAATPFRHGSRRVYTSVRLLRKWKMSGMDVESYILAFLADTQITSRVNMDNVYHIIAELVRSQTFSVGRYLQWLMAKGVANDPLPDQNKAISADVRLLIQLPLARLPEYVRNLRNTLLSRAGITASHEESTVETVKASIAQRLPKIFGPQASDAMLTDQPFSSLTWAVKSEIGLWIRRGVSGHCRDPVRYTDFTPLKYAQVLTAARKYAHIPMLADSGVSALTPVEFYNIRDVLESFGDISMLADVLKQATNCDDNIVLASVADTINFHFDSLSVIGAATDLFKGLVESYARLKRLGAPGLDLIFSLIELGLRMPSEFNTVALLRQDLSRIENKSALAAPSPLSDNLSMAFNDTDSSFQEKLDQILFSGGGMDESTMDSIFNSLTGALANENGHVKLSANDICRYLAYLRSFHPKRFDARLVRWVCGVLKSPSRFAMVRVLPPLIGVGCVTIHAFVMLVKKLLQSERIASVVPKVTDLQLDLLELLVPPEPSGSRYTDMVTYRYYLAQQEFIDKHPEECLNIIRAAVPLISTRQTGSAGEANAADLTKCAMFLLQTLLTQKPERMVQCCTQKLVGQDPASTMILQKALDALLSFNPQDPQAMSEAERVIGMNNDFSLPICQLKLQLLFNAEAGNGVDNGIVDVMFKAAMADARSKRSHWYGLVSLMNQDAVRQIRERAEKGFFSVPILEEPVGDPTVADKSNSIETARLYLAIIEKLAYSIPETGVPSVAPMLVEKMELLLQKFITLQPNPSTPAESCQIAQARSNFERSLAFWFSALLRLVVIHRSAFNTAALTPKPIGLQEQARMLVSIFCITLARLPDRVIRLYPSANYFPHPVQSESYRPCPGILLQTHALDVAAALIDTFPDEARQQCARFLKEKCPPFLQFQNDSRFLYLLGPVMDAPTLNSSQPASLPSPAAGGSTPTPSGNLTGGPPNSQSLSSASGLPAGLSEGVNCIASHLRLQYRGRVLGAYPVRPWELLEDAAPIVGMNDTAVSLKYFDARRVRA
Length1600
PositionKinase
OrganismAspergillus niger
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.07
Grand average of hydropathy-0.169
Instability index48.25
Isoelectric point9.03
Molecular weight176468.82
Publications
PubMed=26893421

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP06487
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     194.73|      63|      69|      40|     108|       1
---------------------------------------------------------------------------
   22-   93 (94.13/65.34)	GSGRVDASQTLVQSDpqlEKLSMSmPQPLPRQPAVIDLTANTSDS.QDREPPAKRlkldaPPGSCPP....EGSPAP
   94-  162 (100.60/55.98)	GSGEARSTPGTGSSK..pNPLAWR.GRPVWSFQALISETTGAVEAkEDDTNPQGK.....TPASPPPlpliPWKPAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     230.73|      77|     310|     893|    1001|       2
---------------------------------------------------------------------------
  698-  778 (115.41/66.59)	RLPeyvRNLRNTLLSRAGITASHEESTV..............ETVKASIAQRLPKI.FGPQASDAMLTDQPFSSLTWAVKSEIGLwIRRGVSGHCR
  906-  997 (115.32/103.39)	RMP...SEFNTVALLRQDLSRIENKSALaapsplsdnlsmafNDTDSSFQEKLDQIlFSGGGMDESTMDSIFNSLTGALANENGH.VKLSANDICR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.41|      10|     886|     517|     526|       4
---------------------------------------------------------------------------
  517-  526 (19.14/11.37)	CLNLKELPDK
 1406- 1415 (19.27/11.51)	CITLARLPDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.06|      26|      75|     588|     613|       5
---------------------------------------------------------------------------
  588-  613 (45.70/29.71)	VAKLLEW......AATPFRHGSRRVYTSVRLL
  660-  691 (40.37/25.29)	VGRYLQWlmakgvANDPLPDQNKAISADVRLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.55|      24|     309|     779|     807|       6
---------------------------------------------------------------------------
  784-  807 (40.83/31.57)	TDFTPLKYAQVLTAARKYAHIPML
  813-  836 (39.73/18.24)	SALTPVEFYNIRDVLESFGDISML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.65|      29|     893|     213|     241|       7
---------------------------------------------------------------------------
  213-  241 (52.90/39.46)	HPEDTLNDHTAKQGHYDRTQV.SQNESNTA
 1108- 1137 (45.75/32.99)	HPEECLNIIRAAVPLISTRQTgSAGEANAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.42|      26|      73|     483|     509|      10
---------------------------------------------------------------------------
  483-  509 (43.31/37.37)	VDRLSRCIRRL..VLeHTSSVILPASWDK
  557-  584 (40.11/28.77)	VIHLFDSIRSAhdVL.STSSACLNAVEDK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06487 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GERVADFSPWTGNHPEDTLNDHTAKQGHYDRTQVSQNESNTARPSLYAQL
2) LNSSQPASLPSPAAGGSTPTPSGNLTGGPPNSQSLSSAS
3) MIPHSSAGVQPWGRSLRALNNGSGRVDASQTLVQSDPQLEKLSMSMPQPLPRQPAVIDLTANTSDSQDREPPAKRLKLDAPPGSCPPEGSPAPGSGEARSTPGTGSSKPNPLAWRGRPVWS
4) QALISETTGAVEAKEDDTNPQGKTPASPPPLPLIPWKPAPQEASGSNSAKPADVASTKEVQTTPYRIVVPPVAPK
200
1499
1
123
249
1537
121
197










Molecular Recognition Features






MoRF SequenceStartStop




1) SFQALI
121
126