<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06481

Description HATPase_c domain protein
SequenceMAQKIDFNALRARTMGSGNDEEAVTVDTRGLISKVLARYSGKWTVLREMIQNAADANATKVTIKFETLPSTTVPLPPAADESTLIKHTISNHTLKRLLISNNGLPFSEKDWARLKRIADGNPDETKIGAFGVGFYSVFDDCEEPFVSSGKEAMAFYWKGNALFTRRLQLDEDANPETTFVLDYRNDTSPIPSLMQLCQFLSSSLTFVSLEGIELWLDDWNLLRLTKKTAPSVNLSIPRDIETKTPQGLMKIQNVTREVAQVDASWMRVIEWNPNASIFREGLRDTTGSLRTFFSKLTGQSAPEKPARPEQQDNSTDSGEMTKTLTASVFLHINTASLQASVSQSLSSELERATRKPPPKRSTIAILTPSYDTTLASGASGLQSEVLSSILPSKGGRVFIGFPTHQTTGLNAHISAPSVIPTVERESIDLNTRYISKWNLEMLRAAGIVCRIAWTAEMASIKARISSGKEFSKSMKVRKDDIAGVLPEAIHTAKQFVFRESTPSSLLGQTIEDAFWTCNKSASIEVLSTCGVIQSHQVRLAPKDLSFMDSIPVLPDEFYSGAREFVKKLTDFGLVTDITVSDIKQELEITTLRSSQAAEFLPWLGQRAASGQLDLYSIQSLLSVAVANEEDESSPQNRLIVFGSIDSYLSPQKIPVNLPVPPTVAPFKFTKSLGKQELEALGWTELQIVPWVRWLVCNSANRNLLPLDQDITKSPSFSAQVLPVLSKQWEYLSQTAKQSVITQLQAHTVIPTKLGMKMPPETYFSSVRLFDDLPVIHGLNGVKEKFLAALGVRKTVELGVIFERLLDTTEAPDGPNNNQRKWSHVDLIRYLASVRDDIPANDIKRLKNTSLCTAEQIDGSGNGDLKAANRKRYKIFELFEPKDSLRALGLPIIEWPGRYQPSSNEGRFLSMLGLRSFPSASELIQIMAQAAADGNWVLHTKAMSYYIAEFHTSGYAMFDCGTVAVPFLPVEGSQGLTVPSKCFTDDGATLFGFAILRTDLHPHASKFGVKQHPALSECIDCLMRQPPSTKRDARVVFKYLAGRVSQLSGRDIDRVGGAQVVPVSTTQDEMEKKVVRRVAPRLCYLGDGEDYKDIFDFVDFGQEANLFLMAVGSKREPTKVEIARMLVKEPARISASFQSADKYLKLLRTLAEHVSTLKKDRELFQEMKRSAFLLASRDITSLAQEQAAKDDHLSDDEEDQSIKEWTLTVAKDAVVVDDFQSFNLFKEHILAAPQEEMLENFYQSLGAQPLSGLVEERAHWGAVAADQRPAAKLQKLISERSRLFLHDQSPDLIRHDVRWLEKHLQVQVVHSISLTRSLKGRRISHTQKRSAIITQQGRDWLLWICPGKYDLYEISQALVHLILVRPKLHSTLTLEMLLKTDLLELKARGYNVERILKQKAHEARMAEDRRQKQLEEERQRLQEREAAWAKEQAQIQAQPHQVQDEREQLMPGDFPDSPSGKNSTRDIQPDTPDQTQDRRPRGFFANLSKRFGLEGNRSPFNAVNGESSQPSRSESSETATPPPPYSAEDPQQKTRSEAPVTVNSPHRLQSELLSAIQACRPHGSSDVYSRPETNQITEKKSYCDEKPSHDLEFVATLACGIHVLFVKNLPDRSQFLAKNSVGINVFASMLMDCAGVFSLRSDILSIFYDPGGKTIAFNRAGSVFCNYFYFQQLHEKQLLANPTADRADALVYWWVILCHELAHNLVGDHSSAHSYYTCVIPTVAISADFQSEKHFSDGDLMAGTPDASMEEILWRSPPHVQMMGGYLHSNNILFYFAESPFFDPTSNNASLAIQANYNEAFRHFVETREAFEGRLKTMQGLEFVVSYDPIQAAAQPDGRFAHEPSNIWVIRKQNRRKRTGLEDEVVVLSTYFIVGDCIYMAPSVASVVGNRILSAVTSLTSLLKTASTLPTFTPSHGHTYMPPALKQADASQPGTQSQQSKENTPLPDADAAGKASLVGSSQVVGTGSSLQDTRTLAESFNLLRRYGEEFMDEHPLVGEPGSFILSRVNDTDRTSAAKPPAPAAKVGTPQVRVDTPGKVSEKGATPSGSEETSSFNNFNDIMSSVNGTKPAVVCVFCGSVSGTNPRHMEAARQLAHEFHKNNIHLVYGGGTAGLMGTIARELVKLSGPQAVHGVIPRALVKVEPGYDNATEHPADTDPNAGVQQARSGKDAERIIPAASTTTTTNGTTAKTKESMFKESEYGTTTIVADMHARKRLMATKVQEGGPGSGFVALAGGFGTIEEVMEMTTWNQLGIHGAGVVVVNVDGYWDGVLAWVRKAVQEGYIGEENGGILVEVNDVKDVWPRLKGYRVSNGRMRLNWGEE
Length2321
PositionHead
OrganismAspergillus niger
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.08
Grand average of hydropathy-0.336
Instability index44.72
Isoelectric point6.26
Molecular weight257036.18
Publications
PubMed=26893421

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06481
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     192.25|      69|      90|     457|     544|       1
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  439-  522 (101.28/97.52)	LEMLRAAGIV....CRIA..wtaeMASIKA...RISSG.KEFSKSMKvrkdDIAGVLPEAIHTAKQ....FVFRESTPSSLLGqtiedafWTCNKSAS
  523-  609 (90.97/81.84)	IEVLSTCGVIqshqVRLApkdlsfMDSIPVlpdEFYSGaREFVKKLT....DFGLVTDITVSDIKQeleiTTLRSSQAAEFLP.......WLGQRAAS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.06|      20|      20|    1896|    1915|       2
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 1896- 1915 (33.15/21.15)	TSLTSLLKTASTLPTFTPSH
 1918- 1937 (35.91/23.65)	TYMPPALKQADASQPGTQSQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.76|      18|      93|     909|     926|       5
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  909-  926 (31.66/20.97)	SMLGLRSFPSASELIQ.IM
 1004- 1022 (29.10/18.59)	SKFGVKQHPALSECIDcLM
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|    1069.56|     351|     391|    1071|    1458|       6
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 1071- 1458 (517.26/449.12)	KKVVRRVAPRLCYLGDGEDYKDIFDFVD..FGQEANL..FLMAVGSKREPTKVEIARMLVKEParisaSFQSADKYLKlLRTLAEHV..STLKKDRELFQEMKrSAFLLASRDITSLAQ.EQAAKDDHLSDDEEDQSIkEWTLTVAKDAVV.....VDDFQSFnLFKEHILAAPQEEMLENFYQ..SLGAQPLSGLVEErahWGAVAADQRPAAKLQKLISERSrlfLHDQ....SPDLIRHD..VRWlekhlQVQVVHsiSLTRSLKGRRIS.HTQKRSAIIT.......QQGRDW....LLWICPGKyDLYEIS.QALVHLILVRPKLHSTLTLEMLLKTDLLElkARGYNVERILKQKAHEA.RMAEDRRQkQLEEERQRLQEREAAWAKEQAQIQAQPhqvqDereqlmpGDFPDSPS
 1460- 1844 (552.30/377.23)	KNSTRDIQPDTPDQTQDRRPRGFFANLSkrFGLEGNRspFNAVNGESSQPSRSESSETATPPP.....PYSAEDPQQK.TRSEAPVTvnSPHRLQSELLSAIQ.ACRPHGSSDVYSRPEtNQITEKKSYCDEKPSHDL.EFVATLACGIHVlfvknLPDRSQF.LAKNSVGINVFASMLMDCAGvfSLRSDILSIFYDP...GGKTIAFNRAGSVFCNYFYFQQ...LHEKqllaNPTADRADalVYW.....WVILCH..ELAHNLVGDHSSaHSYYTCVIPTvaisadfQSEKHFsdgdLMAGTPDA.SMEEILwRSPPHVQMMGGYLHSNNILFYFAESPFFD..PTSNNASLAIQANYNEAfRHFVETRE.AFEGRLKTMQGLEFVVSYDPIQAAAQP....D.......GRFAHEPS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.52|      15|      15|    2109|    2123|       7
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 2109- 2123 (25.96/16.37)	GTAGLMGTIARELVK
 2126- 2140 (27.56/17.89)	GPQAVHGVIPRALVK
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.16|      30|     118|    1957|    1986|       8
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 1957- 1986 (51.21/34.97)	VGSSQVVGTG.SSLQDTRTLAESF...NLLRRYG
 2074- 2107 (45.95/30.52)	VFCGSVSGTNpRHMEAARQLAHEFhknNIHLVYG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     149.25|      37|     114|     645|     681|       9
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  645-  681 (62.58/41.68)	DSYLSP...QKIPVNLPVPPTV..APFKFTKSLGKQELEALG
  728-  758 (34.54/19.24)	WEYLSQtakQSVITQLQ.AHTV..IPTKLGMKMP........
  760-  798 (52.13/33.32)	ETYFSS...VRLFDDLPVIHGLngVKEKFLAALGVRKTVELG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.14|      22|    1999|     258|     281|      16
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  258-  281 (37.75/31.09)	VAQVDASWMRVIEWNPNAsiFREG
 2260- 2281 (41.39/27.29)	VVNVDGYWDGVLAWVRKA..VQEG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06481 with Med6 domain of Kingdom Fungi
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