Description | Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MTDVKDTRKPDQVFTSADRIRQLNEIDKDVAKLIHSAGLAIQALTNARSGESPSDNSLASHQARFKEATSQYFALLSSIDVRLRRQVYALEEASILAPDTASRAENLPGASSGGVAGASSNPLDVSWLNSRKDTVGKDKEAELWAAAREFVERISNPASVSSGAKTEGEQEKMEVD |
Length | 176 |
Position | Head |
Organism | Aspergillus niger |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.538 |
Instability index | 33.32 |
Isoelectric point | 5.18 |
Molecular weight | 18990.76 |
Publications | PubMed=26893421 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP06479 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 64.10| 20| 33| 120| 142| 1 --------------------------------------------------------------------------- 120- 142 (29.22/24.26) SNPLDVSwlnSRKDTVGKDKEAE 155- 174 (34.88/19.46) SNPASVS...SGAKTEGEQEKME --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) KDKEAELWAAAREFVERISNPASVS 2) QEKMEVD 3) RKDTV | 137 170 131 | 161 176 135 |
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