<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06478

Description HHL218Wp
SequenceMSPNKYILTPPDDLHPLNGDEANQEKVYPDFEPWSHNSMDDKLLLSYVGKGHYNGAKVNFESISARSSLQESLPKVADMLADQFSKVIQLREQNINKISSTTDENTAVKPKFMDLAGPGFSLPNRVTLTDQRKAQWLQELSSPNVSLGKLAKSIPYGFKRKQILEQCYLKQIPIQRAIWLIESSYAMDWKSSTSKLKPGQTAESVVSQLYNLWTNNMVSIMERLIFEMPKYYNDIGQLKVWKLRVSYYIKLIGNCYSMGLLDKAVFTHWLVEVVEKIENFEFLPLCLHLLSVFWAELCPIPIEGDMPGETFIISKVTSVLLQKYHIVTQSKAMINDENCIINDLQRNAKLKETILGKLKSFILDIFHNQSLEAFIMPNQNWDMYKSCLYDIVGVDKMMGEKSIVIKKKLELITYRNDSLKFNSLTQCSKNLHQGCDNDPMDIDSNELNGLLFVPCIDPEITTILDNVTPGYDWSNFVQQKFTHVEQVIQLIVWAITPSRKSRYDSAHLVAKLVLLKSTSQESLQEYNMEDFIWKFVFHLSKLSESELTNIVTMPNLFELLNIFISYGIIKVPTYIRKLISSGIMYIPDSKDKFFHCRLLINLKVSPLMKNQYNMVLKNIMEYDSTYFTNFNYDQLQNLLAMAREQLLLDDFEDLPAQPISVKIWVSEWYLSYICSPADDGLKKVDRATIMKNFTIFSVHLKEVIHFYKWVEFIVYHQLLLDLDALNALVDILLCYENLLPLLVNDLILFMKTIIHIYSKELRKTDRTSYEVREFNHFWKFFMKNFPYLVELDSDLQLQLAEVYDSERSRIEKLTKSNVDALALYCDINEIHDENLVKFNAHTFPSIFQQNLKTLLKSDDDDARKNAHKSLLLLMIANIGDYNKFMSIFLKRKDFEIEQLIMLISLKLLTLDLVHKVIGEKFLPEIICKSEYSYGLWFELHKKRYIRKNLKLITSICQPSKLPTNNNFFIDILVEHGTCTKLQEQTCSILYNYLKQHKGDYSLIVRLLNYGIPVELLEEEEIVINPTKLYSRLNFTNMWIFQALTKFYTEALLNEELSDGQTMKDFVFEVIDLTKHDVLCSHVFNMVTHVEVIEKLLQVVEADFFKKCLSDEPDDVQFLTVMIETIMTLSRKVNQGKDRIIMDDNSYQLLQRSMEKFSSMDQTSLKNAGTKLNIYLKIFLVHQRFIFNKICESIRQNYTMCSKLPKSLRLLFENTGFDLKLKLLLYDILSSLKSMAIYESTRKPEVSINGRKFNVPEELQNLPPFHISSFLDESMSITKNDFNSLGIKEHEIMNERNDKNHFFIYNKKKKQYECELDVEPFQLLINYQSKEPGINGHCFNDTVLSLNLFDARFDRKNPT
Length1358
PositionKinase
OrganismEremothecium sinecaudum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Eremothecium.
Aromaticity0.11
Grand average of hydropathy-0.182
Instability index35.84
Isoelectric point6.15
Molecular weight158451.87
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06478
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     377.44|     120|     154|     358|     491|       1
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  358-  491 (189.87/125.44)	LKSFildifHNQSLEAFIMPNQNW.......DMYKSCLYDIVGVDKMMGEKSIVIKKK.LELITYrndslkFNSLtqCSKNLHQGCDNDPMDIDSNELNGLLFVPCIDPEITTILDNVTPgYDWSNFVQQKFTHVEQVI.....QLI
  515-  647 (187.57/97.88)	LKST.....SQESLQEYNMEDFIWkfvfhlsKLSESELTNIVTMPNLFELLNIFISYGiIKVPTY......IRKL..ISSGIMYIPDSKDKFFHCRLLINLKVSPLMKNQYNMVLKNIME.YDSTYFTNFNYDQLQNLLamareQLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.86|      27|      73|      67|      93|       2
---------------------------------------------------------------------------
   67-   93 (43.44/25.93)	SSLQESL.PKVADMLADQFS..KVIQLREQ
  102-  131 (34.65/19.26)	TDENTAVkPKFMDLAGPGFSlpNRVTLTDQ
  141-  166 (42.77/25.43)	SSPNVSL.GKLAKSIPYGF...KRKQILEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     404.79|     130|     521|     689|     824|       3
---------------------------------------------------------------------------
  689-  824 (201.74/135.70)	IMKNFTIFSVHLKEVIHFYKWVEFIVYHQLLLdLDALNALVDILLcYE.....................NLLPLLVNDlilFMKTIIHIYSKELRKTDRTSYEV....REFNHFWKFFMKNFPYLVELDSDlQLQLAEVYDSERSRIE.KLTKSNVDALALY
 1193- 1348 (203.05/118.03)	IRQNYTMCSKLPKSLRLLFENTGFDLKLKLLL.YDILSSLKSMAI.YEstrkpevsingrkfnvpeelqNLPPFHISS...FLDESMSITKNDFNSLGIKEHEImnerNDKNHFFIYNKKKKQYECELDVE.PFQLLINYQSKEPGINgHCFNDTVLSLNLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.69|      47|      74|     933|    1005|       4
---------------------------------------------------------------------------
  933-  985 (78.28/89.95)	YGLWFELHKKRYIRKN.LKLItsicqpSKLPTNNNFFIDILVEHGTCTKLQE.....QT
 1009- 1061 (71.41/34.78)	YGIPVELLEEEEIVINpTKLY......SRLNFTNMWIFQALTKFYTEALLNEelsdgQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.67|      15|     664|       6|      22|       5
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    6-   22 (25.19/23.62)	YILTPPDD.LHPLngDEA
  672-  687 (24.48/14.65)	YICSPADDgLKKV..DRA
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.54|      21|     822|     265|     287|       6
---------------------------------------------------------------------------
  265-  287 (35.01/32.70)	VF...THwlVEVVEK...IENFEFLPLCL
 1082- 1108 (28.53/17.75)	VFnmvTH..VEVIEKllqVVEADFFKKCL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.53|      16|     822|      36|      63|       7
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   36-   54 (24.45/12.35)	HNSMddkLLLSYVGKGHYN
  867-  882 (28.08/ 7.58)	HKSL...LLLMIANIGDYN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06478 with Med12 domain of Kingdom Fungi
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