<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06476

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDILETEFRLEDIVTSYYRVESIKRINYQQFVPRTQDDQWTIQSELILRKKNNKVLVALFSRELWCFSINDDDLPSPFVEGSNEVPHSEKKGSFTPDFSKPNLPTPYAIFLKALRRMIHINMCLSSDNKLIPFGNTCIFEQGNKTSKVFHFDSHLFENGDLTVSFCTKDMNNERLTMDSFNSPTLAQKAVYLAPSGIRAYLPSTDINKCLTSQPKNGNALLMILLVSHGIDLTKKSDIKWIKLVPNLNHLNGYTPTISRYSEECQNTKTVIWPMDLCYFQSPIDIVSYSTKKDSIVNNLQECFDMVDDFMQLKLTSAYRIPGTSANANTATGNNPTSTGGGFTDQMHSFNKYACNSAGNISQSTTKMKLTPTNKLQDAMRSGTSLSTDSFGNGFITTPNINKNTGSAMDEMIGCPSSAKSHGDGPNEGKIYNGQEKQGSSELKREESTNTIQGSADYDPMSFEEDLFGDDDERDLFGDDSGSDQKKGQKEINDNMFEMVDIESDSDNMIYPDRSAAEYNIQQTPLKRKYLDIPLDEITLPSTPLYMDPGAPLPVETPKDRRKSVFAPLNFNPIIESNVDNKYKNGGKFSFDPNEIDEPLKFEVSTTNFSSSEDDDSDFSGEQFGELHPSQLQSTRKLESSLPVSSYDMHPRPMNEYIPPENAKDEGLDVYQNSEGIDIDKLPSRESQLDQIWKSPAISHEESPGRTELSTMLKPTSLEDCVNIEPEQHNFNATSANYFESTSTVSGEEKLSLRVTPFEEKRDSQEEPAETAGGEYSLITKGSRETSNNLPFLLRHMPLFLIPDVFLSHNPSLKINSTLPDLLGILCDQLVFDHDLLGNFGINHPLFKHVRLSKDGVIRKTLSSLFTKFEKIHGNEIIDEMFYMKPPSVYVKKHGELIKVKSDTESFLKYLPLKPSKGMKNFRAFFLTTSLLNFHVSFINELAQLYSGQEFGFCELVKLANDENNGIVVLNNFNRESLLLLSAQIVSYCSTNMTNVRNVPLMLFLPVISASLEDTITMISKFQFIKNEVKSRLPDVEILLKLIPNETIRDPLVSIDQYYELCCSIYNLLPPKKVKFTSIADDLPDNVVFRTSSVNQSQIIHYDSYIHLAYTRSIDREWLCAAWSDSKGTENIVKAWHLGNSKSRFEEACNEIWKITVGLASTKYGRICLILTRMDSVLPDDELMHWRRLSITTRNLHLAVVCVGHNTKVSLYDEDINYPSFKQLYKDKSNANKVDPDALDDYVIVNIDEEIHGIIFKSPLQLANSQHRCSIKSGALLKFKPSAGNSTLDKFEVNLLNCQHSDSTALLKTILQQFRDLACLNSWFCISKKNDNYMPWHVVAVNKVMNFIVHVKGIEEKGQ
Length1358
PositionKinase
OrganismEremothecium sinecaudum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Eremothecium.
Aromaticity0.09
Grand average of hydropathy-0.442
Instability index43.36
Isoelectric point5.31
Molecular weight153596.88
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06476
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     519.06|     167|     378|     769|     961|       1
---------------------------------------------------------------------------
  769-  961 (252.61/220.18)	ETAGGEYSLITKGSRETS.NNLPFLLRHMPLFLiPDVFLSHNPSLKInsTLPDL.LGILCDQL.....VFDHDllgnfgINHPLFKHVRLSKDGViRKTLSSLFTKF......EKIHGneiideMFYMKPPSVYVKKHGELIKvksdTESFLKYLPLKPSKGMKNFRAFFL......TTSLLNFHVSFINELAQLYSgqefGFCelVKLAND
 1145- 1330 (266.45/169.73)	EEACNEIWKITVGLASTKyGRICLILTRMDSVL.PDDELMHWRRLSI..TTRNLhLAVVCVGHntkvsLYDED......INYPSFKQLYKDKSNA.NKVDPDALDDYvivnidEEIHG......IIFKSPLQLANSQHRCSIK....SGALLKFKPSAGNSTLDKFEVNLLncqhsdSTALLKTILQQFRDLACLNS....WFC..ISKKND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     188.61|      43|     151|     426|     469|       2
---------------------------------------------------------------------------
  358-  392 (48.47/28.88)	.......GNISQSTTKMK.LTPTNKLQ.DAMRSGTSLSTDSFGN
  426-  469 (70.18/50.83)	NEGKiYNGQEKQGSSELKREESTNTIQGSADYDPMSFEEDLFGD
  584-  625 (69.96/45.95)	NGGK.FSFDPNEIDEPLKFEVSTTNFSSSED.DDSDFSGEQFGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.74|      25|     795|     149|     174|       3
---------------------------------------------------------------------------
  149-  174 (43.24/34.61)	FHFDSHLFENGDLtVSFCTKDMNNER
  972-  996 (43.50/29.58)	FNRESLLLLSAQI.VSYCSTNMTNVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.16|      36|     795|     237|     273|       4
---------------------------------------------------------------------------
  237-  273 (63.28/48.70)	DIK.WIKLVPNlNHLNGYTPTISRYSEECQNTKTVIWP
 1034- 1070 (59.88/41.03)	DVEiLLKLIPN.ETIRDPLVSIDQYYELCCSIYNLLPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.35|      32|     379|     321|     355|       5
---------------------------------------------------------------------------
  321-  355 (55.52/44.65)	PGtsaNANTATGNNPTSTGG..GFTDQMHSFNKYACN
  703-  736 (51.83/33.57)	PG...RTELSTMLKPTSLEDcvNIEPEQHNFNATSAN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06476 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KLSLRVTPFEEKRDSQEEPAETAGGEYSLIT
2) LKFEVSTTNFSSSEDDDSDFSGEQFGELHPSQLQSTRKLESSLPVSSYDMHPRPMNEYIPPENAKDEGLDVYQNSEGIDIDKLPSRE
3) QLDQIWKSPAISHEESPGRTELSTMLKPTSLEDCVNIEPE
4) STDSFGNGFITTPNINKNTGSAMDEMIGCPSSAKSHGDGPNEGKIYNGQEKQGSSELKREESTNTIQGSADYDPMSFEEDLFGDDDERDLFGDDSGSDQKKGQKEINDNMFEMVDIESDSDNMIYPDRSAAE
749
599
687
386
779
685
726
517










Molecular Recognition Features






MoRF SequenceStartStop




1) IDEPLKFEVST
2) PMSFEEDLFGD
595
459
605
469