Description | Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MSDSLNSPPAYDFSGVPAPALDAIRMRLSQLTHSLSKIRDDMSKAELPQWYSLQAQLAVTLSQLSSLTATLQHFEDALDSTVPYPLPNFPTTAHEGMLTTLMRKKQIPEVEAWIKDAIDSSGIELSSESQEDVERRIRHDRDETNWALKFVNHERDNYSFQGLYTAEELTSMSGDPTRALYRSSNSKAMPKTPFSVESILTYIYQGPKAREASRTPS |
Length | 217 |
Position | Head |
Organism | Eremothecium sinecaudum |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Eremothecium. |
Aromaticity | 0.08 |
Grand average of hydropathy | -0.572 |
Instability index | 55.15 |
Isoelectric point | 5.26 |
Molecular weight | 24403.02 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP06474 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 68.72| 14| 21| 180| 193| 4 --------------------------------------------------------------------------- 163- 176 (22.46/12.33) LYTAEELTSMSGDP 180- 193 (23.42/13.12) LYRSSNSKAMPKTP 203- 216 (22.84/12.64) IYQGPKAREASRTP --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) KTPFSVESILTYIYQGPKAREASRTP 2) PTRALYRSS | 191 176 | 216 184 |
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