<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06468

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMGDFPPPERTSVKASELVHRAVDKSYEDFRTLIHQLPTMREEERREPLLAHLQSSRKRFAQLLAVLKWSVQSPLLQQCDTLLQQTETYRNNVNETNDRLFFMHADLNRAKERRYDLSTAADVLYGGSYLRLPTIIKNAMFPRELPEVDTEQAATEVADIIRFRLIEADIPEQFSNIKLEGGFVTCQAEGEFEIVLTIQGKEKDAKWRVISVNTALTDAQAFEDHSQAASTSALRIIRSNAPNAAHYNHLKNLVQRAMNKSEKPFVDAFMVMREFCSSLALQILASQGKLLMEGRWKNRIMIKHLRDQNILDICYWPKACVRKEAQALTEQQRLIQQLSDPIATARRGSALPYPESSLCVRLGFDPNKKKLLSVSLSPSLPPNLPGYASLLSALEVPSNMFLLSAENLLIAAMRAHVSAALFSIGRLLVVDSPDDKASTQLVSGEDVAMVCSDTSLRIARADIGGLQQFLEVTFDIREGRFIVSSVAAARQSALYITVKQLERILNTQCKIELGGNVDKSFPNDFALVSGDGKGDKSNELIHTSVRKVLCEIVADEVAQIGSSFKGIEVLRSVNLNWERYLAFRQQHGGQTEDLSISDTALYFQLTSSKESTCYLVIEIDKYGEVDGMNGNVHEAAEAEEYIRLPCFSLLQTSAGLPGQPSGVQFIQRFGAFKKEDLHPSVTRHNEIIGNSLRGNSRKRPYSSNGTSLVGRNMRTTKKALLDGGRVQESTGYWLDDAEHQAVSRNFVPHIASVLLHAINMCSERIQLQHFVNFARRRKSRIRYSGEAGTANREGTGGQVVTLSFPEKVNTDPLKIVAIQGHLKHGGGFELCLQLASPPFKFISPKKPKDHLLSERSHYVNERGQLIFRYPTTMVTSELFSENPLEMFMVELICVVRPLCELAVKLEKMLTAVGRYTNDIKDDGHFYVESADPFAIVLACRAPNPRHCIAAGSSPDGLTTYRVTVQFKQKMGFVVNYSHKAEHPLMHFIQSALNGHSDPAQFVEALERTCVPMGILASVVESQLLCAKYYRQDPPPNAKDGAANGGPKAFGRGKMGGKGMKLGYKFKLPGEEKGYYAEKSIGGDDKSFVPAELVMIPRSQTQVRLSYGDRCAVDIYFLENHSVKMQSSSGGVRVPSCPSEKGIVVDCQNFAEKLRSTLSEMASA
Length1162
PositionTail
OrganismPhytophthora nicotianae (Buckeye rot agent)
KingdomOomycetes
LineageEukaryota> Sar> Stramenopiles> Oomycota> Peronosporales> Peronosporaceae> Phytophthora.
Aromaticity0.07
Grand average of hydropathy-0.277
Instability index40.10
Isoelectric point8.35
Molecular weight129344.41
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06468
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     452.17|     183|     595|     174|     421|       1
---------------------------------------------------------------------------
   32-  311 (241.40/208.95)	LIHQLPTMREEERREPLLAHLQSS...RKRF....AQLLAV.LKWSVqSPLLQQCDTLLQQTETYRNnvnetndrLFFMHADLNRAKERRYDLSTAadvLY...................................................................................................................................................................................................................................................................................................................ggsylrlptiiknamfprelpevdteqaatevadiirfrlieadipeqfSNIKLEGGFVTCQAEGEFEIVLTIQGKEKdakwrvisVNTALTDAQAFEDHSQAASTSALRIIRSNAP.....NAAHYNHLknLVQRAMNKSEKpfvdafmvmrefcsslalqilasqGKLLMegRWKNRIMIKHLRDQNILD
  333-  421 (76.87/81.08)	LIQQLSDPIATARRGSALPYPESSlcvRLGFdpnkKKLLSVsLSPSL.PPNLPGYASLLSALEVPSN........MFLLSAENLLIAAMRAHVSAA...LF...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  778-  884 (133.90/72.97)	.....................................................................................................sigrllvvdspddkastqlvsgedvamvcsdtslriaradigglqqflevtfdiregrfivssvaaarqsalyitvkqlerilntqckielggnvdksfpndfalvsgdgkgdksnelihtsvrkvlceivadevaqigssfkgievlrsvnlnwerylafrqqhggqtedlsisdtalyfqltsskestcylvieidkygevdgmngnvheaaeaeeyirlpcfsllqtsaglpgqpsgvqfiqrfgafkkedlhpsvtrhneiignslrgnsrkrpyssngtslvgrnmrttkkalldggrvqestgywlddaehqavsrnfvphiasvllhainmcseriqlqhfvnfarrrkSRIRYSGEAGTANREGTGGQVVTLSFPEK........VNTDPLKIVAIQGHLKHGGGFELCLQLASPPfkfisPKKPKDHL..LSERSHYVNER........................GQLIF..RYPTTMVTSELFSENPLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.36|      35|     594|     430|     520|       2
---------------------------------------------------------------------------
  433-  470 (54.59/108.15)	DDKAstqLVSGEDVAMVCSDTSLRIARADIGGLQ.QFLE
 1082- 1117 (58.76/13.86)	DDKS...FVPAELVMIPRSQTQVRLSYGDRCAVDiYFLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.32|      43|     345|     689|     738|       6
---------------------------------------------------------------------------
  689-  738 (65.63/54.65)	NSLRGNSRKRPYSSNGTSLVGRNMRTTKKALLDGgrvqESTGYWlddAEH
 1035- 1077 (77.69/46.54)	NAKDGAANGGPKAFGRGKMGGKGMKLGYKFKLPG....EEKGYY...AEK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06468 with Med14 domain of Kingdom Oomycetes
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