<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06467

Description Type-2 histone deacetylase 2
SequenceMAYDKAALKYFGRPTGSTDAHPGEIVLNFPEKRDEFLKQLMEEEKQKMARQTGGSNYASRSAQNAKYNLSIMKLNSWMSKLQRSVKMVEASQRVEWGLHPESMKTEEEQETKQEEEEATNVSSLVKTEIFGSGPTIKREFTTRDQKLRQNKKEIQEAIALMVEELKIYAADAPVDPLFQPPPRCAPILDLLSTSRHLKLISAINDLAHLKVKVDGKDPHSVVDGRFESKLQAVVDYRARLQMSSSNEKQKLANYMRELETVTSPSPTSLPGGATTTGGETQASKQPNILKNAKYVKRKVPISKPQKPQVIDLMSDEDSPQQEDKEMKKEPVATTTEDSPADVKPEVIAVEEQDQPESSTDETIAKQKETASTSTGSGDEEPSSVSVEEKSTNSADSGDNAASQDATNDKESGEKETKVTTDSSETTKEEESKEGSPDADKTEEGKAEPEVPEDKAEADKVEEVETEKTEADTPDGDSAEDAKPGAYQSTASSVEDEPDTAKTDEDITMEDAEEDGGEVSSSTTIVVPKDEFEWQFCLAIQLPSAKESPTTCDGVWRLLPLSSKTQMGEFIEDVFLTENEVSEMEISEEEVCSSSAATDGKTPWMEHLRQLHVEESQVRQQIQRETNHQHALQGIMKIEQDRLNQISVVYREAMNKLDTKTSLALKNHARVSQDAQLVKLMQHSFNPILGDLLDKCEEALLNCFRKLSLRFVDFSQEFEYYRTALLNLTQSSGKENPTEEGQSSPVDASDLVLDDVTIKRENIAKVTGEAADTDPTIGTGDSVKVVDDSEATPVDESDEFDDLGDSSGLREAYINFYMGEMEALWKERSSSLEMVQAIQRSLLHTTLQVDASTAKPVEVQKASEVKSSDDAEMKVEESEDAENTVESTEMEAQSEEKTAESEENSEVSQEGTASTGGATIEKEADVIVEQADVNTPEAVSSKPESTQVSSEVVVKIEPQEEVSGKFRREQELREAVESCLAQWQRIQWPEELNSTFLTPTTSSISSTTSPVIKSEHIKTQTCSAADEEEAEYESPYSVMDELKRVMIDLTQDQVIPVPPQVEPTTLVMYHPVFINHQTPKDHPECPERMDRVVNILNTLVKKHQDTLKLERLSMSPEELCPPETTLLMVHSPTYLRQLKERSIEAGSQSASSPTASSPSSRALVFESDSGIREETPKRDGRKKNGRPLLAGAFGAASLEQNGVELDTFVSSKSWDVARAAAGTVCLAVDRVVRKEYHNAVCLVRPPGHHVGRHGRTQNAPSSGFCLLNNVVIGATHARLYPWIRKVAVLDWDIHHGNGTEELLMDDPDAFFASIHLYSAGKYFPGTGKSCETGNRVNVALENTGAGSGSQAFRSALELKVLPAIRAFQPDIIFISAGFDGHRDDILGGVAAVNNPNVPAGYVEEDYAWATLEVLKLAAEVCDGRVVSVLEGGYDVRRETNSLAKSVAAHVAAISAYEAARRMSDDSGTVDVEMKEEDAADKAVAPAGSATSAQGAVVIKTEHPIKQEPVGLLEKLLSTDLDDDNVVIIDDEDNEEEGGETTHDVHDGEDVEDEDTGEEDDGDVAMADAEGEPESEEPHDHSEKSGQDAMDVDDTNAMSDPFYLADILLGRVGVLRSTAESIILELCEAQTKLEPGQASDDALRLAIKNKLERVQTNLKLLRKLVPEFDGKTKPIEGVSQTHRNLMLEYHWKNQVQDMGAKAQAVYLEQLSATFPRLEMLGDVRCPPTPSSLFVPKSHKRGRVFDPFGEKQPATLNEMMDYMMAKNRKLKFFKHAETTRGGRRVIKSIKCEINKEVTVHLSFCPPIPENGPNGESGVAASPMTPSTPTSPAFAGGRLRSTRNKHKKQQQQLVKKKKGDMLTKAKLAAEEATKMEMEELKQRITEAREAIKEQEQARAAGLQVTKYIQRLSIFPYNEDAPLGAWSESSHNLFRLVTLHGRKALDHFRKQHPETCFYHLFTWLGYYDKIYQTPCSFCKKLLAKESEEWAYVPPSFRDYANGQAFHSKCLPIE
Length2008
PositionTail
OrganismPhytophthora nicotianae (Buckeye rot agent)
KingdomOomycetes
LineageEukaryota> Sar> Stramenopiles> Oomycota> Peronosporales> Peronosporaceae> Phytophthora.
Aromaticity0.05
Grand average of hydropathy-0.660
Instability index52.13
Isoelectric point4.80
Molecular weight222113.66
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06467
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     188.87|      63|     235|     582|     673|       1
---------------------------------------------------------------------------
  598-  669 (99.54/129.04)	DGKTPWMEHLRQLH...VEESQVRQQIQRetnhqhalQGiMKIEQDRLNQISVVY.R.EAMNKL...DTKTSLAL.KNHAR
 1667- 1738 (89.32/52.79)	DGKTKPIEGVSQTHrnlMLEYHWKNQVQD........MG.AKAQAVYLEQLSATFpRlEMLGDVrcpPTPSSLFVpKSHKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      62.42|      17|      17|     427|     443|       2
---------------------------------------------------------------------------
  432-  450 (19.86/ 6.83)	KEGSPDADKTEEgKaEPEV
  451-  468 (19.85/ 6.82)	PEDKAEADKVEEvE.TEKT
 1559- 1573 (22.72/ 9.09)	DGDVAMADA..E.G.EPES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.49|      47|     185|     529|     582|       3
---------------------------------------------------------------------------
  529-  582 (71.38/64.29)	DEFEWQFC..LAIQLPSAKESPTTcDGvwrllpLSSKTQMGEFI.EDVFLTENEVSE
  715-  764 (70.11/43.51)	QEFEYYRTalLNLTQSSGKENPTE.EG......QSSPVDASDLVlDDVTIKRENIAK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      66.36|      17|      18|     273|     289|       4
---------------------------------------------------------------------------
  273-  289 (25.67/12.42)	ATTTGGETQASK..QPNIL
  292-  310 (18.53/ 6.66)	AKYVKRKVPISKpqKPQVI
  331-  347 (22.15/ 9.58)	VATTTEDSPADV..KPEVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     447.58|     149|     667|    1071|    1229|       5
---------------------------------------------------------------------------
 1071- 1229 (222.76/143.22)	VFiNHQTPKDHPECPERMDRVVnILNTLVK..KHQDTLKLERLSMSPEElC..pPETTLLMVHSPtylrQLKERSIEAGSQSASSP.TASSPSSRALV...FESDSGIREETPKRDGRKKNGrPLLAGAFGAASlEQNGV...ELDTFVSS.....KSWDVARAAAGTVCLAVDR
 1741- 1906 (224.83/116.41)	VF.DPFGEKQPATLNEMMDYMM.AKNRKLKffKHAETTRGGRRVIKSIK.CeinKEVTVHLSFCP....PIPENGPNGESGVAASPmTPSTPTSPAFAggrLRSTRNKHKKQQQQLVKKKKG.DMLTKAKLAAE.EATKMemeELKQRITEareaiKEQEQARAAGLQVTKYIQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     128.52|      27|     111|     382|     408|       6
---------------------------------------------------------------------------
  349-  385 (32.61/17.40)	VEEQDQPESSTDETIAKQKETAStstgsgdeepSSVS
  386-  408 (28.59/14.10)	VEEKSTNSADSGDNAASQDATND..............
  469-  491 (32.05/16.93)	..EADTPDGDSAED.AKPGAYQ...........STAS
  492-  519 (35.27/19.58)	SVEDEPDTAKTDEDITMEDAEED.........gGEVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     376.03|     142|     666|     786|     986|       7
---------------------------------------------------------------------------
  786-  986 (172.74/164.24)	DDSEATPVDESDEfdDLGDSSGLREAYINFYMGEMeALWKERSSSLEMVQAIQRsLLHTTLqvdastakpvevqkasevkssDDAEMKVEESEDAENtvestemeaQSEEKTAESEENSEVSQEGT.....................................astggatiekeADVIVEQADVntpeaVSSKPESTQVS.SEVVVKIEPQEEvsgkfrREQELREAVESCLaqwQRIQ
 1463- 1653 (203.29/96.28)	DDSGTVDVEMKEE..DAADKAVAPAGSATSAQGAV.VIKTEHPIKQEPVGLLEK.LLSTDL.....................DDDNVVIIDDEDNEE.........EGGETTHDVHDGEDVEDEDTgeeddgdvamadaegepeseephdhseksgqdamdvddtnamsdpfylADILLGRVGV.....LRSTAESIILElCEAQTKLEPGQA......SDDALRLAIKNKL...ERVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.87|      24|     873|     134|     186|      10
---------------------------------------------------------------------------
  163-  186 (45.26/63.48)	EELKIYAADAPVDPLFQPPPRCAP
 1039- 1062 (42.62/12.18)	DELKRVMIDLTQDQVIPVPPQVEP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06467 with Med27 domain of Kingdom Oomycetes


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DDNVVIIDDEDNEEEGGETTHDVHDGEDVEDEDTGEEDDGDVAMADAEGEPESEEPHDHSEKSGQDAMDVDDTNA
2) DDSGTVDVEMKEEDAADKAVAPAGSATSAQGAVVIKTEHP
3) EWGLHPESMKTEEEQETKQEEEEATNVSSL
4) LKERSIEAGSQSASSPTASSPSSRALVFESDSGIREETPKRDGRKKNGR
5) SFCPPIPENGPNGESGVAASPMTPSTPTSPAFAGGRLRSTRNKHKKQQQQLVKKKKGDM
6) SNEKQKLANYMRELETVTSPSPTSLPGGATTTGGETQASKQPNILKNAKYVKRKVPISKPQKPQVIDLMSDEDSPQQEDKEMKKEPVATTTEDSPADVKPEVIAVEEQDQPESSTDETIAKQKETASTSTGSGDEEPSSVSVEEKSTNSADSGDNAASQDATNDKESGEKETKVTTDSSETTKEEESKEGSPDADKTEEGKAEPEVPEDKAEADKVEEVETEKTEADTPDGDSAEDAKPGAYQSTASSVEDEPDTAKTDEDITMEDAEEDGGEVSSSTTIV
7) STFLTPTTSSISSTTSPVIKSEHIKTQTCSAADEEEAEYESPYS
8) TGEAADTDPTIGTGDSVKVVDDSEATPVDESDEFDDLGD
9) TTLQVDASTAKPVEVQKASEVKSSDDAEMKVEESEDAENTVESTEMEAQSEEKTAESEENSEVSQEGTASTGGATIEKEADVIVEQADVNTPEAVSSKPESTQVSSEVVVKIEPQEEVSGKFRREQE
1521
1463
95
1137
1799
245
993
766
844
1595
1502
124
1185
1857
525
1036
804
970










Molecular Recognition Features






MoRF SequenceStartStop




1) NILKNAKYVKRKVPI
287
301