<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06463

Description CMGC/CDK/CDK8 protein kinase
SequenceMPLKLRHAYPHQPPHHYYSSSSSSAHRLYADGRDQSAGYQPKARVTERYRIIGFISSGTYGRVYKAVSRTTNPEGIAVVRTSSGLTPTSNSGPAPIEVAIKKFKPDKEGEQVSYTGISQSAIREMSLCSELRHPNVIRLVEIILEDKCIFMVFEYAEHDLLQIIHHHTQQPRHPIPPATVKSIMFQLLNGCQYLHTNWVLHRDLKPANIMVTSGGEVKIGDLGLARRFDKPLHSLFSGDKVVVTIWYRAPELILGSYHYTPAIDMWAVGCIFAELLSLRPIFKGEEAKMDSKKTVPFQRNQMHKIAEIMGLPTKERWPLLPFMPEYSQLNTLSTMQHNTHSHHHHHHQNPPNRGYPPTSHLEKWYYNTINNNSGAGSAASGPNGQPALQSLGAEGYKLLAGLLEYDPEKRLTAAQSLQHEFFSTGDRVSSNCFEGIKVEYPHRRVSQDDNDIRTSSLPGTKRSGLPDDTLLRPAKRMKE
Length479
PositionKinase
OrganismTrichoderma gamsii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.08
Grand average of hydropathy-0.539
Instability index45.74
Isoelectric point9.17
Molecular weight54035.82
Publications
PubMed=26893428

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06463
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.60|      27|     178|     150|     177|       1
---------------------------------------------------------------------------
  150-  177 (50.08/36.34)	FMVfEYAEHDLLQII.........HHHTQQPRHPIPP
  322-  357 (48.52/29.86)	FMP.EYSQLNTLSTMqhnthshhhHHHQNPPNRGYPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.01|      36|     429|       9|      47|       3
---------------------------------------------------------------------------
    9-   47 (62.79/44.46)	YPH....QPPHHYYSSSSSSAHRlyaDGRDQSAGYQPKARVTE
  440-  479 (59.23/34.35)	YPHrrvsQDDNDIRTSSLPGTKR...SGLPDDTLLRPAKRMKE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06463 with CDK8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AYPHQPPHHYYSSSSSSAHRLYADGRDQSA
2) RRVSQDDNDIRTSSLPGTKRSGLPDDTLLRPAKRMKE
8
443
37
479










Molecular Recognition Features






MoRF SequenceStartStop




1) DDTLLRPAKRMKE
467
479