<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06455

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSPDVLLIPFPWQHSYGYNYDYLLEDTVSRIVTRYGAFRKLEESSFFNIDKDINDTDDCLKNNQNFNVFDTSIGLKYDFQQVKEKLINMIANAQNECSLILDFVSLLVSSVKSALGNSSMSTFLKERVPVGSFGTERVKGDICEEDKAVSKGWKIQALSKAASDLLDASIRIDKETTLETKFWHHVTLLKQNGWNLMHSRINNSKNLIVNYGIMDVARIFGKGFAILQKNTEGGIEFDGIDVNEMFKTIRLRFVENNIVKGDVVWDNSSLFDFFDKNIQTLSRRKDSFFEEELLEEIIREVSFFDDLNAIIMDNGVSVEILGPKRVLLIDIVDASIEIKESNGEYDVLCEAILLALHLFFSYYESQKLKWIDDLPFLSKMQSKKQSRVLFPVLSQLAHYFVLNEIFEELNNCINVILLEGWSVNYKIRKYVGMDFGVSEDSIIQSIIDGSQSVIEIYLPGSSQIVINIQTNNYKTSFEVDFRDSGVDEVISKTVCGSIFEVLDCIIWSINRDFMNVLQEIVAPQWKIKNGELLNINNGKRIKIDILLQRGEDGIWKILLYKNGIFIHVENSKISDFIYKII
Length581
PositionHead
OrganismPneumocystis jirovecii (strain RU7) (Human pneumocystis pneumonia agent)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Taphrinomycotina> Pneumocystidomycetes> Pneumocystidaceae> Pneumocystis.
Aromaticity0.11
Grand average of hydropathy-0.067
Instability index40.60
Isoelectric point4.94
Molecular weight66698.59
Publications
PubMed=26899007

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06455
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.66|      16|     102|     304|     319|       1
---------------------------------------------------------------------------
  304-  319 (28.59/19.97)	FDDLN...AIIMDNGVSVE
  406-  424 (24.07/15.57)	FEELNnciNVILLEGWSVN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.00|      25|     222|     269|     298|       2
---------------------------------------------------------------------------
  269-  298 (32.18/30.48)	SLFDFFDKNIQTLSRrkdSFFeeELLEEII
  497-  521 (42.82/24.85)	SIFEVLDCIIWSINR...DFM..NVLQEIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.79|      41|     369|     153|     205|       3
---------------------------------------------------------------------------
  153-  205 (50.86/63.29)	WKIQalskaASDLLDAS....IRIDkeTTL...ETKFWHhvTLLKQNGwNLMHsrINNSK
  525-  572 (63.93/38.94)	WKIK.....NGELLNINngkrIKID..ILLqrgEDGIWK..ILLYKNG.IFIH..VENSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.07|      25|      39|      31|      59|       4
---------------------------------------------------------------------------
   31-   59 (33.95/37.85)	IVTRYGaFRKLEESsffNIDKDINDTDDC
   73-   97 (43.11/30.45)	IGLKYD.FQQVKEK...LINMIANAQNEC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06455 with Med17 domain of Kingdom Fungi
Unable to open file!