<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06451
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MDSLAPPLPKVTEGMVPLKEVIERLVYYAFSELQNMLDILPSMSNVMKKRTILEYLLSTKRQMIKLYVLIKWAHSSEEVKRCIDIVAFLQGQKNCFSNLIHALKTIISQLSYARVRSPDIFTAMEVFSTGTFSRLEFSETSTAFMLPRNLKPNEVLQTFNTLNILISLRLSLYQVIPYPMISYVVENGRAKFVVENEFVIFLSFVGENISKIDDFVWFLVDFEWNFDRAPVISDNIKDEIEKLANEILKLSVIQKKEPLVELYNFLHKFTLFYKLEVIVVEAKEMSFKGWKDKLNVSFDNFKRTLTLKYWPVFTSSEKNIKSWPNSIGIFVGEPKKKNIASYMFPYTRISFDYDCSVISYSWKIGDDFQCCEDLNINESNISAKEIILKVIGFHSMILLKKVCLTLLESSSFSSSSVFILNADENNENPILKIQCSKAKSILIFVKPMCGKFRLVEYDSFLCSSLVIKNYEKLINIPNQNILELLIRLKCKILYDDIESKAKFLGWEVVKFPSGSFKQKEFKNNLGLEIKYTIFLTNSILGWKQPSSKSIFFVVCLLSGQNTNWWLLETAISKYDVFLGWNILWSEKIRIHDGKRRKSSELDFSLIFDFSPTYSLLESIHKYSIIRVAILQFSRDLDMRGIHYGYLHDFSISQLWIIPFFHFYTGDISPLAKVWVCKNMFAQFLFSGHSFDELKIIFYGKLTNLKFLIVLMQQYKRDDIELNVKSNYFLIKVIYKMGKNISLVIDLFLELWLKIETIIRFVFKSNEFNHFLVLESFNIDTVRFSYYKKKHFWLEIGYESSDKKVKFPSIKYSLEIGAIDGYINPHTRIKTHLCQILEDSRGNVRLFSEIVYKTLPFLETIEQLEATTLEKSEFHVLFQSSLQFSIVYAKKRHALGVILRSAPSHLLDNDMITLNEGTLVYYIFDLALKYQAADFLETSKIKGQNSENGTVESENIVHARAKKLNYLKSTYNVIEACQFIWSKGIDVEEYKKTIFPAENGLLCTSDAISCVINKIHTMILDYDCMK |
Length | 1025 |
Position | Tail |
Organism | Pneumocystis jirovecii (strain RU7) (Human pneumocystis pneumonia agent) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Taphrinomycotina>
Pneumocystidomycetes> Pneumocystidaceae> Pneumocystis.
|
Aromaticity | 0.13 |
Grand average of hydropathy | 0.038 |
Instability index | 42.09 |
Isoelectric point | 8.60 |
Molecular weight | 119336.83 |
Publications | PubMed=26899007
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP06451
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 626.89| 174| 187| 353| 539| 1
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241- 418 (215.45/147.71) .E.......KLANEILKLSVI...QKKEPLVELYNFLHKFTLfykLEVIVVEAKEMSFKGWKDKLNVSFDNFKRTL.TLKY.................WP.....V.......FTSSEKNIKSWPNSIGIF..........VG................epkkkniasymfpytrisfdydcsvISYSWKIG.............DDFQCCEDLN........INESNISA.KEIILKVIGFHS..MILLKK..VCLTLLESSSFSSSSvF
423- 539 (152.48/106.67) DE.......NNENPILKIQCS...KAKSILIFVKPMCGKFRL...VEYDSFLCSSLVIKNYEKLINIPNQNILELLIRLKCKI..LYDDIESKaKFLGWE.....V.....VKFPSGSFKQKEFKNNLGLE..........IKytIF.......LTNSI................................................................................................................
577- 690 (84.78/46.94) ...............................................................................................FLGWN.....IlwsekIRIHDG.KRRKSSELDFSL...............IFdfsptysLLESI.........................HKYSIIRV.............AILQFSRDLDmrgihygyLHDFSIS..QLWIIPFFHFYTgdISPLAKvwVCKNMFAQFLFSGHS.F
691- 873 (174.17/104.33) DElkiifygKLTN..LKFLIVlmqQYKRDDIEL.NVKSNYFL...IKV.........IYKMGKNISLVIDLFLELWLKIETIIrfVFKSNEFN.HFLVLEsfnidT.....VRF..SYYKKKHFWLEIGYEssdkkvkfpsIK...........................................YSLEIGaidgyinphtrikTHL..CQILE........DSRGNVRLfSEIVYKTLPF....LETIEQ..LEATTLEKSEF......
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 44.85| 11| 187| 817| 828| 2
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339- 349 (22.04/ 8.93) IASYMFPYTRI
818- 828 (22.80/14.73) IDGYINPHTRI
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