<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06451

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDSLAPPLPKVTEGMVPLKEVIERLVYYAFSELQNMLDILPSMSNVMKKRTILEYLLSTKRQMIKLYVLIKWAHSSEEVKRCIDIVAFLQGQKNCFSNLIHALKTIISQLSYARVRSPDIFTAMEVFSTGTFSRLEFSETSTAFMLPRNLKPNEVLQTFNTLNILISLRLSLYQVIPYPMISYVVENGRAKFVVENEFVIFLSFVGENISKIDDFVWFLVDFEWNFDRAPVISDNIKDEIEKLANEILKLSVIQKKEPLVELYNFLHKFTLFYKLEVIVVEAKEMSFKGWKDKLNVSFDNFKRTLTLKYWPVFTSSEKNIKSWPNSIGIFVGEPKKKNIASYMFPYTRISFDYDCSVISYSWKIGDDFQCCEDLNINESNISAKEIILKVIGFHSMILLKKVCLTLLESSSFSSSSVFILNADENNENPILKIQCSKAKSILIFVKPMCGKFRLVEYDSFLCSSLVIKNYEKLINIPNQNILELLIRLKCKILYDDIESKAKFLGWEVVKFPSGSFKQKEFKNNLGLEIKYTIFLTNSILGWKQPSSKSIFFVVCLLSGQNTNWWLLETAISKYDVFLGWNILWSEKIRIHDGKRRKSSELDFSLIFDFSPTYSLLESIHKYSIIRVAILQFSRDLDMRGIHYGYLHDFSISQLWIIPFFHFYTGDISPLAKVWVCKNMFAQFLFSGHSFDELKIIFYGKLTNLKFLIVLMQQYKRDDIELNVKSNYFLIKVIYKMGKNISLVIDLFLELWLKIETIIRFVFKSNEFNHFLVLESFNIDTVRFSYYKKKHFWLEIGYESSDKKVKFPSIKYSLEIGAIDGYINPHTRIKTHLCQILEDSRGNVRLFSEIVYKTLPFLETIEQLEATTLEKSEFHVLFQSSLQFSIVYAKKRHALGVILRSAPSHLLDNDMITLNEGTLVYYIFDLALKYQAADFLETSKIKGQNSENGTVESENIVHARAKKLNYLKSTYNVIEACQFIWSKGIDVEEYKKTIFPAENGLLCTSDAISCVINKIHTMILDYDCMK
Length1025
PositionTail
OrganismPneumocystis jirovecii (strain RU7) (Human pneumocystis pneumonia agent)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Taphrinomycotina> Pneumocystidomycetes> Pneumocystidaceae> Pneumocystis.
Aromaticity0.13
Grand average of hydropathy0.038
Instability index42.09
Isoelectric point8.60
Molecular weight119336.83
Publications
PubMed=26899007

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06451
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     626.89|     174|     187|     353|     539|       1
---------------------------------------------------------------------------
  241-  418 (215.45/147.71)	.E.......KLANEILKLSVI...QKKEPLVELYNFLHKFTLfykLEVIVVEAKEMSFKGWKDKLNVSFDNFKRTL.TLKY.................WP.....V.......FTSSEKNIKSWPNSIGIF..........VG................epkkkniasymfpytrisfdydcsvISYSWKIG.............DDFQCCEDLN........INESNISA.KEIILKVIGFHS..MILLKK..VCLTLLESSSFSSSSvF
  423-  539 (152.48/106.67)	DE.......NNENPILKIQCS...KAKSILIFVKPMCGKFRL...VEYDSFLCSSLVIKNYEKLINIPNQNILELLIRLKCKI..LYDDIESKaKFLGWE.....V.....VKFPSGSFKQKEFKNNLGLE..........IKytIF.......LTNSI................................................................................................................
  577-  690 (84.78/46.94)	...............................................................................................FLGWN.....IlwsekIRIHDG.KRRKSSELDFSL...............IFdfsptysLLESI.........................HKYSIIRV.............AILQFSRDLDmrgihygyLHDFSIS..QLWIIPFFHFYTgdISPLAKvwVCKNMFAQFLFSGHS.F
  691-  873 (174.17/104.33)	DElkiifygKLTN..LKFLIVlmqQYKRDDIEL.NVKSNYFL...IKV.........IYKMGKNISLVIDLFLELWLKIETIIrfVFKSNEFN.HFLVLEsfnidT.....VRF..SYYKKKHFWLEIGYEssdkkvkfpsIK...........................................YSLEIGaidgyinphtrikTHL..CQILE........DSRGNVRLfSEIVYKTLPF....LETIEQ..LEATTLEKSEF......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.85|      11|     187|     817|     828|       2
---------------------------------------------------------------------------
  339-  349 (22.04/ 8.93)	IASYMFPYTRI
  818-  828 (22.80/14.73)	IDGYINPHTRI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06451 with Med14 domain of Kingdom Fungi
Unable to open file!