<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06437

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMVAAPSPQNTLSNGAYENGTLEPSMEELERELPIVLDGQVPLGELLSRVMQTVFAELSEMAETLPNSSDTARKRMLADWVVKTKKQIVKLYAIAKWSRDADTVQKCMNITAFLMDQNRQFEDAIVGLNYARESLDPARLRNHDLLTSLDVLTTGSYRRLPTAIKKSIIPPTPLTDAQVLKTLRDIQDVIRYRLRLREIIPIEMSRHRIADGCVYFTAPKLFEVSIRLTGAQPHDRWLFVHVDFLLNIGGDMTGTQDFPRTPSGIMKKFISEEVDRQLGMYIPGPAPQEQLPPGVVHPIKPELPDDVADAPLVRLFNFLQMMALSYQLEILWYQAERMRSLGWGDYLTVSMSPNRKVMSVSYWVRQPPPQVPGRQQSKLPLLGGTVTISIIDCSTSFSSVKRSSRALALAELQQKAKLGAMRPSDVVEGLKFEVRWEPTAGALGVNVSAQDCVLPEGTLMVNHDNLDFELMLRKVIHQHARAVLARYQLQLQHTSVPRSVFAGPGVVILVDNKEILALRVVLCADKVITISIDARTGRFIFRDVGDLSPGGQAPKYAVIFEKVNEAPALMLRMLSNLRVETLIELVEQKANYLGLQSYRRRNFLPEEMQKLGTGAQGTLYIQLRSYPPYYLVIVIFLDEFRYALITTELLPESPCANLVMKDIAWLDFNRIHNEEVTIIEPSAQKIGFKRKLPEGDDGDAPSRASFQLETQVLRELYNYCCARVAYMNVERQLKLRNIPFTHVNPASGHPVTPELAHIQSSLARSVPALCVQSKHILEGAPAAEAAMPNIRVIPLNWWSEKNAQVVTCVKLKYVQQPMGKTAGTSAVIRPSKRIIYDTTEAVVSFLSENVNTCVDEFLEEWARVSKMVVIAREVAQMSKTKDKKDISLLSFDLQTVEFAYAEDYTVSITTSEDRSSITGAKFDLRFSRIRSTRRGLTPDSDEWFNPHDDAEPFLRDVLRQGHGRLAPSLHRLVDILRDTLSIVTGLEEIRKESEKEENNLPVDTFAKSAGWYRLIYGDLRHGLDFRLLSNQRVAILDASHSLFNGSSSSIRGSTDSVMSNPNDLPNLGLQPIPDFSAVINESVLEAIAAEEAFSGKLAAIEWGVVTDKAAVKSIMKRIHRKVWSKLYSSS
Length1129
PositionTail
OrganismMoniliophthora roreri
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Marasmiaceae> Moniliophthora.
Aromaticity0.07
Grand average of hydropathy-0.169
Instability index47.88
Isoelectric point7.06
Molecular weight126778.49
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06437
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     446.04|     182|     453|     134|     377|       1
---------------------------------------------------------------------------
  134-  199 (48.55/45.95)	...............................................................................................................................................................................................................................LDPARLRNHDLLTSL...DVLTTGSY..RRLPTAikkSIIPPTPLTDAQVLK..TLRDIQDVIRYRLRLREII
  222-  475 (248.92/208.73)	EVSIRLTGAQphdrwlfvhvdfllNIG.......GDmTGtqDFPRTPSGIMKKFISEE.............VDRQLGMyipGPAPQEQLPPGVVHPIKPELPDdvADAPLVRlfnflqmmalsyQLEILWYQAERMrsLGWGDYLTVSMsPNRKVMSVSYW...............VRQPPPQVPGR....QQSKlpllggtvtisiidcstsfssvkrssraLALAELQQKAKLGAMrpsDVVEGLKFevRWEPTA...GALGVNVSAQDCVLPegTLMVNHDNLDFELMLRKVI
  674-  831 (148.57/76.64)	EVTIIEPSAQ..............KIGfkrklpeGD.DG..DAPSRASFQLETQVLRElynyccarvaymnVERQLKL...RNIPFTHVNPASGHPVTPELAH..IQSSLAR............SVPALCVQSKHI..LEGAPAAEAAM.PNIRVIPLNWWseknaqvvtcvklkyVQQPMGKTAGTsaviRPSK.....................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.13|      28|     453|     552|     581|       2
---------------------------------------------------------------------------
  552-  581 (43.93/33.71)	APKYAVIFEKVNEapALMLRMLSNLRVETL
 1008- 1035 (48.21/30.19)	AGWYRLIYGDLRH..GLDFRLLSNQRVAIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.39|      22|      35|      69|      90|       3
---------------------------------------------------------------------------
   69-   90 (37.60/24.31)	DTARKRM.....LADWVVKTKKQIVKL
  101-  127 (33.79/21.16)	DTVQKCMnitafLMDQNRQFEDAIVGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.70|      14|      30|     880|     893|       4
---------------------------------------------------------------------------
  880-  893 (23.05/14.91)	KDKKDISLLSFDLQ
  911-  924 (23.65/15.48)	EDRSSITGAKFDLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.37|      14|      35|      20|      33|       5
---------------------------------------------------------------------------
   20-   33 (23.65/12.41)	TLEPSMEELERELP
   52-   65 (22.72/11.67)	TVFAELSEMAETLP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06437 with Med14 domain of Kingdom Fungi
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