<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06421

Description Coiled-coil domain-containing protein 47
SequenceMMESRDVLYATPYRPKSSAAHVFESIKPTPLLNITPECSEDDDSNSGTSEKSSDKTLKREIADSSLHSCYHGKQLNRPFLNTCEAIIEKIKRVKKIDPSTLAKEQIRRNEHYYQKIAMKKENARSIVQNIKSIQSSISEVLAKLQMVDQPSLLNSFRVISSQFNSMLQLLRSDRASHFKNYVFLPIKLSVEVDADLEAATENRLHAWTHAVVPDYLRTKPDPQVEQKDQQISNQVQQRICNPESLQKQITAFNRCLNCILDSLNASIRDSEMDGRKTSKTSDGEDTALLVAAILKGQNVKPAYSATPASSRGSSGDSGHSKASKAQQVQCCFILKKQCMAKNKCSININQFTTERRKTCIWMFFLSCLFEFVELSVKQVSQIDDNEFAEFEEFDVELDASVDADFTANNVNERETPPVDTASIGAKRSPAYAEQKRNDAPNNNFNDDDYGIVEDESVDDFSHLLDENEFENFPDERRPGKQNAGPSKTVTQLKITDTKNHSLAVAWFDSNRPFLEENFSIVGDDGISPEVTKNVLIKESDNHYIVWCSGRQGCIGMEIHLKLIKRQDLLSLIFYIIRPKFDVIEIKIILNPEEMDPFVFALGTKRSAIKNSKEIMDLNLYCSEKKNVEKLGLPSSYILHSEIGEVTTGLIDTKIVSALCKYKDVVDYIHISDQFVGIKPIEMENMTKPPETAKVVMICLNIPGQLRATEEDVSSLQPLMIFIFHVLEKVRRFRLTREGKQKADKNRQYVEESFLKTTHAQRQEAAQQRREERARERKERLMAEEDPERQRKLEKQELKRELKKKQPRVKQIKIKAMLRFLIKAKQIHC
Length828
PositionHead
OrganismTrichinella sp. T8
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella> unclassified Trichinella.
Aromaticity0.07
Grand average of hydropathy-0.584
Instability index48.76
Isoelectric point7.49
Molecular weight94665.79
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro
rough endoplasmic reticulum membrane	GO:0030867	IEA:UniProtKB-SubCell

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06421
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.98|      21|      38|      86|     106|       1
---------------------------------------------------------------------------
   86-  106 (33.18/21.74)	IIEKIKRVKKIDPSTLAKEQI
  126-  146 (32.80/21.41)	IVQNIKSIQSSISEVLAKLQM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.45|      37|      38|     455|     491|       2
---------------------------------------------------------------------------
  455-  491 (65.10/44.46)	ESVDDFSHLLDENEFE.NFP..DERRPGKQNAGPSKTVTQ
  493-  532 (55.34/36.64)	KITDTKNHSLAVAWFDsNRPflEENFSIVGDDGISPEVTK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     176.91|      55|     206|     178|     234|       3
---------------------------------------------------------------------------
  178-  234 (88.77/66.86)	FKNYVFLPIKLSVEVDADLEAATENRLHawTHAVVPDYLRTKPDPQ.VEQKDQQISNQ
  387-  442 (88.14/58.82)	FAEFEEFDVELDASVDADFTANNVNERE..TPPVDTASIGAKRSPAyAEQKRNDAPNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     138.20|      36|      36|     624|     659|       5
---------------------------------------------------------------------------
  601-  621 (26.59/13.47)	......LGTKRSAIKNSK...EI....MDLNL...YC
  624-  659 (57.34/36.82)	KKNVEKLGLPSSYILHSEI.GEVTTGLIDTKIVSALC
  662-  698 (54.27/34.48)	KDVVDYIHISDQFVGIKPIeMENMTKPPETAKVVMIC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.75|      27|     270|      24|      52|       7
---------------------------------------------------------------------------
   24-   52 (42.65/35.22)	ESIKPTplLNITPECSEDDDSNSGTSEKS
  297-  323 (47.10/31.48)	QNVKPA..YSATPASSRGSSGDSGHSKAS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06421 with Med8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AQRQEAAQQRREERARERKERLMAEEDPERQRKLEKQELKREL
2) DFTANNVNERETPPVDTASIGAKRSPAYAEQKRNDAPNNNFNDDD
759
404
801
448










Molecular Recognition Features






MoRF SequenceStartStop




1) RDVLYATPYR
5
14