<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06415

Description Mediator of RNA polymerase II transcription subunit 15 (Fragment)
SequenceLSLIMEDDWRSQRQREKVIQHLDNVIRSCTVPLNIPGDARQVENAIFLKASNQEEYMQFVSKIIYHASSGAAAMSQPQRHQAPVNQVPYGNMQPGTQFRRADMRPMQQPMQQQQQQQQQQQQQQVPGQIYSGMRAPPNAEMQPRLLRPMHQPSVTMHHMHQQQAQMGQMGMTQSAGIAAAAQQQPQNVVMLLTSGNPPRQAASAPSAVQLRQPNDIQQFLQQLPPAIRQQILQLPPEEQAEQLKKFFESRRWQQQQQLHQQQQIQQQQQQQQQQQQQQQQIQQQIQQHQQQQQQLQVQQQIQHQMHHVAQNQMHTQAVIQQQQQQQQQQQQQQQQQQQQQHQQQFASVRQQQQMQMLQPMMQQPGAVRFADQSTTMLYSRPPATPVMIPQTPAPVQQPPSQPAPVTPMSGQAASPNVNIGTPYPSSSPAGAHMMGPSPAYAAETSPVCHPAATPGPKTSQMSPAANSLPPESIGAEHSPYKEKVNELLVYLEPLKRLIEQTKESTSDSSQTQKFQRMVDILEGRNDTSMDVLLKCEETLKMICQKSDIIKLCKHRELHVTVFSPDCLKGSCENETAQASNVEDSDQISIPLNIQREIGSLESKFRVTIDPSQRPLRSSCKFISVLCELLDITLPSVPPIYIRIPTNYPQSPPKYDLEWSQYCDSPYLNSIRKSLESFSSDTGAPNTISALLTNWETCVRDASFI
Length704
PositionTail
OrganismTrichinella sp. T8
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella> unclassified Trichinella.
Aromaticity0.05
Grand average of hydropathy-0.815
Instability index80.63
Isoelectric point7.38
Molecular weight79900.24
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06415
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     413.74|      63|      65|     237|     299|       1
---------------------------------------------------------------------------
   76-  117 (55.70/ 9.63)	...............QP......QRHQAP.VNQ....vpYGN.......MQPGTQ.F..RR....ADMRP.MQ.Q.PM...........QQQQQQQ
  118-  186 (85.71/19.40)	QQQQQQQVPGQIYSGMR......APPN.....A......EMQ.......PRLLRPMHQPS..VTMHHMHQ.QQaQMGQmgmtqsagiaaAAQQQPQ
  209-  273 (97.52/23.24)	QLRQPNDIQQFLQQLPP......AIRQ.....QilqlppEEQ.......AEQLKKFFESRRWQQQQQLHQ.QQ.QIQQ...........QQQQQQQ
  274-  328 (97.27/23.16)	QQQQQQQIQQQIQQHQQ......QQQQLQ.VQQ....qiQ..........HQMHH.V......AQNQMHT.QA.VIQQ...........QQQQQQQ
  329-  401 (77.55/16.74)	QQQQQQQ.QQQ.QQHQQqfasvrQQQQMQmLQP......MMQqpgavrfADQSTTMLYSRPPATPVMIPQtPA.PVQQ...........PPSQ...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.87|      16|      16|     423|     438|       2
---------------------------------------------------------------------------
  423-  438 (32.65/16.22)	YPS.SSPAGAHMMGPSP
  440-  456 (24.21/10.06)	YAAeTSPVCHPAATPGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.49|      10|      16|     594|     604|       3
---------------------------------------------------------------------------
  594-  604 (13.60/11.32)	QREIGSlESKF
  612-  621 (19.89/11.66)	QRPLRS.SCKF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06415 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QQQQQQQQQQQQHQQQFASVRQQQQMQMLQPMMQQPGAVRFADQSTTMLYSRPPATPVMIPQTPAPVQQPPSQPAPVTPMSGQAASPNVNIGTPYPSSSPAGAHMMGPSPAYAAETSPVCHPAATPGPKTSQMSPAANSLPPESIGAEHSP
2) SGAAAMSQPQRHQAPVNQVPYGNMQPGTQFRRADMRPMQQPMQQQQQQQQQQQQQQVPGQIYSGMRAPPNAEMQPRLLRPMHQPSVTMHHMHQQQAQMGQMGMTQSAGIAAAAQQQPQNVVMLLTSGNPPRQAASAPSAVQLRQPNDIQQFLQQ
329
69
479
222










Molecular Recognition Features






MoRF SequenceStartStop




NANANA