Description | Mediator of RNA polymerase II transcription subunit 6 |
Sequence | MNRQKKVKMIYCFNMNVHGSSQITNPLHIQWNPPWNPNWLSASNVLDCFTNTLNPFYDPNCLNEQVRIQRLSSEILSRVHGVEYILLHAAEPLFVIRKQYRQPNQNVTPLEDYYIIGGTVYQAPDLSSVFNSRLQSAISNVRSAFEEGIRFFSYFNAKVTCDCFCIIAKSYYRFNTSDGYYFQYKNEPPVEKVDTKKDDKTGDDKRVSVFQKYRMDMLLNELSEKFPPALSLEESNENTQNGKMTSNEEPQTSAQSKNDQMESPALSASKKIKSDMN |
Length | 277 |
Position | Head |
Organism | Trichinella sp. T8 |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella> unclassified Trichinella. |
Aromaticity | 0.11 |
Grand average of hydropathy | -0.660 |
Instability index | 41.47 |
Isoelectric point | 6.90 |
Molecular weight | 32018.70 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364143 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP06410 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 109.98| 36| 60| 175| 217| 2 --------------------------------------------------------------------------- 175- 217 (53.14/40.44) NTSDGyyfqyK...NEPPVEKVDTKKDDKtgDDKRVSVFQKYRMDM 238- 276 (56.84/27.30) NTQNG.....KmtsNEEPQTSAQSKNDQM..ESPALSASKKIKSDM --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 43.31| 14| 64| 25| 38| 4 --------------------------------------------------------------------------- 13- 34 (22.07/10.92) FNMNvhgssqitNPLHIQWNPP 35- 56 (21.24/10.28) WNPNwlsasnvlDCFTNTLNPF --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) KNDQMESPALSASKKIKSDMN 2) YFQYK 3) YRMDMLLNELSEKFPPALSLE | 257 181 213 | 277 185 233 |
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