<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06383

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMASCTVAWEKKPLKRPRLGQPDVYPQDPKQSEANYDDRFISSNFINDELTAEKVRQGFIYKPPLLNEYESLRSQRFDENLEDYFIKLTQSYNAIVNKKAEINALQDSYKKKSGFKEPSIWHFFIAPLAAKPKGQDTWFKDLSGNKPLSALGKRFPFLNKKDEILYTLAEFNVPMVRVVWFLKMTNAHIAQQQECGKMKKKHMSDPFADWTHLVMKYLRDLCSKLGEFFSLNLEVPMNSEFECHYRHWQYTTKLTRHLFEEGLLDKEMLLNGLLDIFAEKIYASSFGILKMLVPVLLQFIDGFVMSVLLSRRLVYLACKVLSAMKIDNLQNNSENMKEEDEEEEGTLDYLNCPFHRTVLFGLSNVIHAVLIDCPTALIWNEMECEDTGENGKAYLCGSPLDLLHCSPVDLPLFMDPSTEFVKKELERLTEMVTERSRAVESHWSYNKCQHSGLSESTIIQHFLSILDCLDKFKFEYVNETNNIDTLYKTIFQSEKKEMRVDVDSIAVQFLCHWAVSPHRYGSYRAAVVTRLFERHLQEVKHDEFQLSKKMPQVRHPFQKSLFNYLHNQAPNLGEMCSSSEIKPFTNLILLFSRLIESDIFSHDQYVSTLVSSGDLIPNGANIFYPLQNQCSSAAVENVSNTQPAVLMSSNFFSEQFKPIEVSNVDFNYFKDSDESKLDFDRIIDFADKKAMSSDTDSCSSKRVPKLSKHYFNVLHFPVPQDDQYRHECNQRQLLLFGSNSDQYSRKHILKKLTKELNKLWSKKTSAELTTTGLIRVRKIIDSESLCSLSRKIQNLVFYDQFAVMDCCCDAGIAQFNSFISGQSNCLPTLENFDFLLGLLEESSNFISLVEFVEAIICLLPKLEAQIVERNFQCANSLTLQYAVCMVGYMRKHHCYFIQLESVMCNIWRSLLLYVKSKTVVNSFSAERCVWVYLHDLYQCCSYIRSLHADLYLNSRDCIQRCLCVETKPSCCNDLRTLLADVSQDIMLDVLFQESDLVIEPNLIQRLVENANLCYAFAIVAVKALCGLSGDTERLFNLVLFCADVTALCPNLNADWLAVFKILCCPFNSSQDQSSCDSLLNIDVSDHQCYQPLTVLVITLISRMCIRLEDFILHVAMPSLLPLWKHAGSAKVEKGSEASAKLTLHLLGKILLFFDYQGPKNALPAKTKGELSLICSSVDGMVPDAILTLLIAILMLDDSKVQELKSKENFDTKRSAAKQFVEEDTNTAGNSDIGSTAIQLLELICRQEWTKRKFLHSTDLFDPKRLLNPLVNQTQAQRLLRMITRSDSEILLKKFDSCTTKKELISKVLDSLTIMNLWVSQMDLQLLLKQVANSQSESLHLVDTIAKSCMEVFQPQATLAFGEPSDDKDENAYLNASSFDEIAPYWLVAPLISRLPSFVQGRVLKAAVSILENCQARRDRNLFVQSSSLLAHQPFLSLVLICLRGQDDQREGLLSSLLKQIQEFVMRVKEDPYILCDRDIVSEMLDALQLRLSLIGGMFDTVCRNANLENWSLVMVQLLLYGIVTEEKNQALFYTCVDILCVLLLSCLLPDSAGFSFSGQERTNEDCKRIYNNVIKKLKVKEIGDRQVPSLRCVHQLLPIPRQMVDIIVCDEYGSQPQKGSRGGFSSSEVTQRKGLQIIGKEKLNPWEIIEGYNRENIGLKWSWFQGIRLDYQPETLFEQMMRMLPHDHHHAFNRPPMPGEPRSDPFLETLQVHYLPCTNETSDSDKLTTERLKSNGPVAISGGTLVSEFSDQVQSPRTTKARARKSTRGRKTSSRVTVSSNVALSSVPPMVQNRQLGIGQPTLTAHYGYYPQQVAMTGGPSGAVPPYGQGQMWSIGNVQSASTAVPPTQYQSRNFTGAQMTPVQSSSGKQAISAMIRGRRPSGSGGQQMMTTAHIQAAPLATGQPYHQQQLHSIGQVDPMVAPMHQVQMQMDARQQLMQESMMEQQQIRTPGPRSMATQQHCLPQVNSAASQPVMHGNYSNYPGQHGGGRMQMTSGRNQYAAQQPAQPPFNCSPNYNAQFYQAQNAGQMRMSQTDVIGQSNVRYTQQPNAIGSSYQMQSQQTLRAPAGYVAQQANPMYAAPNTPQYQAAQQQNVSMYPVSRMSQYSSNVPGQEMNASQQQINYYPPQY
Length2127
PositionKinase
OrganismTrichinella sp. T8
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella> unclassified Trichinella.
Aromaticity0.09
Grand average of hydropathy-0.280
Instability index48.68
Isoelectric point6.47
Molecular weight241268.76
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06383
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     221.68|      25|      35|    1968|    1992|       1
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 1815- 1832 (21.03/ 7.18)	.......MTG.GPS.GA...VPP....YGQGQM..W
 1840- 1864 (22.30/ 8.11)	ASTAvPPTQY.QSR.NF...TGA....QMTP.VQ.S
 1865- 1889 (22.04/ 7.92)	SSGK.QAISAmIRG.RR...PSG....SGGQQM..M
 1896- 1919 (29.20/13.18)	AA...PLATG.QPY.HQ...QQL....HSIGQVDpM
 1931- 1955 (30.78/14.34)	DARQ.QLMQE.SMM.EQ...QQI....RTPGPRS.M
 1968- 1992 (46.80/26.09)	AASQ.PVMHG.NYS.NY...PGQ....HGGGRMQ.M
 2000- 2030 (26.15/10.94)	AAQQ.PAQPPfNCSpNY...NAQfyqaQNAGQMR.M
 2043- 2068 (23.38/ 8.91)	YTQQ.PNAIG...S.SYqmqSQQ....TLRAPAG.Y
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     305.15|      71|      86|     588|     658|       2
---------------------------------------------------------------------------
  555-  583 (33.35/16.65)	..............................PFQKSLFNYLHNQAPNLGE................................MCS........SSEI..KPF
  588-  658 (123.47/86.63)	LLFSRLIESDIFSHDQYVS..TLVSSGDLIPNGANIFYPLQNQCSSAAVENVS.....................NTQPAVLMSSNF.....FSEQF..KPI
  676-  747 (55.11/33.54)	LDFDRIID...FADKKAMSsdT...................DSCSSKRVPKLSkhyfnvlhfpvpqddqyrhecNQRQLLLFGSN.......SDQYsrKHI
  785-  852 (93.22/63.14)	CSLSRKIQNLVF.YDQF.A..VMDCCCDAGIAQFNSFISGQSNC.LPTLENFD.....................FLLGLLEESSNFislveFVE.......
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     173.42|      52|      82|      26|      78|       3
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   26-   78 (86.03/60.99)	QDPKQSEANYDDRFISSNFINdELTAEKVRQGFIYKPPLLNEYESLRSQRF......DE
  105-  162 (87.39/57.21)	QDSYKKKSGFKEPSIWHFFIA.PLAAKPKGQDTWFKDLSGNKPLSALGKRFpflnkkDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     130.02|      27|      28|     938|     964|       4
---------------------------------------------------------------------------
  903-  931 (34.28/21.28)	.CNIWRSLL..LYVKSKTVVnsfsaERCVWVY
  938-  964 (53.79/38.31)	CCSYIRSLHADLYLNSRDCI.....QRCLCVE
  969-  992 (41.95/27.97)	CCNDLRTLLADV...SQDIM.....LDVLFQE
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     165.25|      53|      67|    1535|    1590|       5
---------------------------------------------------------------------------
 1535- 1590 (83.72/62.70)	VDIL.CVLLLSCLLPDSAGfSFSGQERTNEDCKRIYNNviKKLKVKEI..G.DRQVPSLR
 1603- 1659 (81.53/50.58)	VDIIvCDEYGSQPQKGSRG.GFSSSEVTQRKGLQIIGK..EKLNPWEIieGyNRENIGLK
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     342.87|     103|     191|     163|     276|       6
---------------------------------------------------------------------------
  171-  276 (175.59/143.46)	NVpmVRVVwFLKMTNAHIAQQQEC...GKMKKKHMSDPFADWTHLVMKYLRDLCSKLGEFFSLNLE..VPMNSE.FECHYRHWQYTTKLTRHLFEEGLLDKEMLLNGLLDIF
  363-  471 (167.27/108.46)	NV..IHAV.LIDCPTALIWNEMECedtGENGKAYLCGSPLDLLHCSPVDLPLFMDPSTEFVKKELErlTEMVTErSRAVESHWSYNKCQHSGLSESTIIQHFLSILDCLDKF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.73|      20|      26|    2077|    2097|       7
---------------------------------------------------------------------------
 2077- 2097 (35.58/31.34)	YAApNTP.QYQAAQQQNVSMYP
 2104- 2124 (34.14/23.27)	YSS.NVPgQEMNASQQQINYYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.60|      36|      44|    1114|    1153|       8
---------------------------------------------------------------------------
 1114- 1153 (46.85/54.45)	AMPSLLPLwKHAGS.....AKVEkGSEASAKLTlhLLGKILLFFD
 1156- 1196 (55.75/41.66)	GPKNALPA.KTKGElslicSSVD.GMVPDAILT..LLIAILMLDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.98|      12|      35|    1281|    1292|       9
---------------------------------------------------------------------------
 1281- 1292 (18.79/10.67)	ITRSDSEILLKK
 1317- 1328 (18.19/10.06)	VSQMDLQLLLKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     117.10|      28|      30|    1406|    1433|      11
---------------------------------------------------------------------------
 1366- 1383 (19.30/ 7.28)	..........................KDENAYLNASSFDEI.APY
 1406- 1433 (48.71/30.57)	VS.ILENC...QAR............RDRNLFVQSSSLLAH.QPF
 1434- 1462 (28.84/14.84)	LS.LVLIClrgQDD............QREGLL...SSLLKQiQEF
 1479- 1515 (20.25/ 8.03)	VSeMLDAL...QLRlsliggmfdtvcRNANL..ENWSLVMV.Q..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.19|      28|      36|    1725|    1753|      17
---------------------------------------------------------------------------
 1692- 1710 (25.18/10.93)	.........NRP.PMPGEPRSDPFLETLQ
 1725- 1753 (40.65/27.12)	KLTTERlKSNGPVAISGGTLVSEFSDQVQ
 1764- 1791 (42.35/23.98)	KSTRGR.KTSSRVTVSSNVALSSVPPMVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      59.46|      12|      36|    1201|    1212|      18
---------------------------------------------------------------------------
 1201- 1212 (19.47/ 9.86)	ELKSKENFDTKR
 1240- 1251 (19.24/ 9.65)	ELICRQEWTKRK
 1252- 1263 (20.75/10.99)	FLHSTDLFDPKR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06383 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GTLVSEFSDQVQSPRTTKARARKSTRGRKTSSRVTVSSNVALSSVPPMVQNRQLGI
2) IGNVQSASTAVPPTQYQSRNFTGAQMTPVQSSSGKQAISAMIRGRRPSGSGGQQMMTTAHIQAAPLATGQPYHQQQLHSIGQVDPMVAPMHQVQMQMDARQQLMQESMMEQQQIRTPGPRSMATQQHCLPQVNSAASQPVMHGNYSNYPGQHGGGRMQMTSGRNQYAAQQPAQPP
3) RMLPHDHHHAFNRPPMPGEPRSDPFLETLQ
1742
1834
1681
1797
2008
1710










Molecular Recognition Features






MoRF SequenceStartStop




1) MASCTVAWEKKPLKRPRLGQ
2) YYPPQY
1
2122
20
2127