<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06381

Description "Serine--tRNA ligase, cytoplasmic"
SequenceMSVSLSDFEAKVKNLFKEHAKSGIAHFFFRPYLITSSEECEKEIVISTANELMEIFTSLPQNLQESAFSIVISHRVLSNSANKIVDFFVRNVIQRQMLSIKCICEKLLTCAELNINSCGWNDTFAFFMENISLLDYKGVRDTLKRLLDIPIPVHLQVDQRKSVEAVEKLIKTICDRKNNLLPAYFVITEIIKNLPEQRCFSHWRMADCFTEIIESFRPLAQLNSVCGRTFMTPIPGHVGFYFNAFWKLEALSLRFPLKGLLPYSQDLLNPQMRLLTHVFMHYTYRDAIAVLLGTAKPEKSRIPYFEEVITEIILELMFTAECDHSQLNPQAWRIISTQIIYLTLQQSICFTRLVKILHTKLTHYPYRYARNQLMWCLFNFLSGGMQKYSVEEFAVILDLYRLLYTGRDIFTVSGSDSSCVLMLAPTCIWIHILKKSPSMEVELPPTVNTQRKFLQEALKNKTQFNTDNYMVAVLCNAYSSTSEIFQQDLLPILLENLDNTRGHNSTQASGNFASNTTSSMPYPNGAVSEVKLRPLKLEFLDSVSVHVRMNIANSLIGTFGRFMQGKSAWPSPALVETYCRMLTYPDLEILGLKQFTSHIVLTAARHQCCEMMYICCEILNYRLFNIPSTYRVHAIVTLQQTLAFAKFQTNASLYWMLERTLLLQFQWYPHYEIFQAPFARLLNSFVAVAADGTKQSIAENEELMRIIILTLARSTQVDEEYIKHRTFGSELSLIDYFTNTSTSTVYLCLLWRLVYDTGELPAVSMKILEVLGPRKVLVHLKSLADFLVYETNSADVNRCVDVLNRLIFKYAVVPLERFMLTMLLRDYEGNDAFYALLIVMLLVQRSEELRSAVADCVAMLPSDYWHCQDWNDKYQAYQIKHAERTWSQVYVELSRASLTPNDCPLPVYFGTRCLQMLPVVDLLLQKLVESPAACLKFLDSTLSILGPLYRFHPYPVSFLYSTFRFYEKRLVESPAIKQKLALAVHGACVPSRDDHWLLSAEFVGWVGQATDRGPWVPDLNYYGALVRRLIDTFSEPRQQWSRKTDLRFVEFNNFQTHALYSICIELMSLPVGVVDVGNALVTLVTHWHSLVDKNTVMYWVNAIGLIFSALPISYMEPFYQTILTTLCSDNMNSINTDVSNKLDFEKRSKLMEDCYPARILALCHAVWLHSTSGYLQLLPQALRSTWIPHVRSEGQFLYVCHLVAPFLQRFYQERTKFTMDITTDLYQMLYNVDCEVGNWKYEDLICDFFYHVKYMYVGDSVRQDTDRIIPMLRPSLQQKLRYISFAQGEQSAGTPFSEMINPIKLLGIQMVVWLQRLPIFGETAQHFWLAVTKLGDPLCFHFLAPLRWIWILLDDRPYWWVHTAGVSGQLSHPLKQFQWTCETGPGSPSGHAMVSASVWFNLLYNLQSDLVLGDLCGICWLLYVVFLIAVSISRTYISAHFPDQVILGIVVGICIALVTRSLVGHRRRRWSNLIAFMIALLLIALSVHEVHRFFGVDTHRSIELAAKYCHRAEWIHQSTTPLASFFRDVGVLISVAILLANKSMFTNNNKIASKFFSTKFAQALLGVGLNQLVAFIPIGRLPTALFYAVLLPALIVLLLTMVLDLDNFRVEKGGNVQAVRVSQQKRFQSVDLVDQVVETDQEWRRSRYLSDEWNRLKNLCSKEIGEKIKRKEPVDGNSTLPDSLTDKLQKLTVDQIRALSVGQIKQLRLLIDHEMEKSYKLVENLEAVRFKALSQIGNLVHNSVPVSENEDDNEIVRTWGELEVRKKYSQVDLGIMVDGYDSERGCSVAGSRGYFLKGPLVFLEQALIQLAMHMLFKKKYTPLYTPFFMRKEVMQEVAQLSDFDDQLYKVIGKSSEVKEEIAEEEKYLIATSEQPIAAYHRDEWISKESLPLRYVGFSTCFRQEVGSHGRDTSGIFRVHQFEKVEQFCITSPHDDASWEMLEEMISNAEMFYQTLNIPYRVVSIVSGELNNAAAKKYDLEAWFPGSGAFRELVSCSNCTDYQSRRLRIRYGQTKKMMAKAEFVHMLNGTMCATTRTICAILENFQEENGIAVPEALRQYMPDDYKDFIPFVKPAPKVEQAAKRGNKSATAEKSTQ
Length2095
PositionTail
OrganismTrichinella sp. T8
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella> unclassified Trichinella.
Aromaticity0.11
Grand average of hydropathy0.002
Instability index40.03
Isoelectric point6.99
Molecular weight240659.10
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-KW
serine-tRNA ligase activity	GO:0004828	IEA:UniProtKB-EC

GO - Biological Process
seryl-tRNA aminoacylation	GO:0006434	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06381
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      95.29|      18|      18|     924|     941|       1
---------------------------------------------------------------------------
  888-  904 (20.56/ 8.74)	.QVYVELS.....RASLTPNDCP
  905-  920 (24.46/11.89)	LP..VYFG.....TRCLQMLPVV
  924-  941 (31.39/17.50)	LQKLVESP.....AACLKFLDST
  942-  962 (18.88/ 7.38)	LSIL..GPlyrfhPYPVSFLYST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.58|      20|      20|    1451|    1470|       2
---------------------------------------------------------------------------
 1451- 1470 (35.84/24.81)	VGICIALVTRSLVGHRRRRW
 1474- 1493 (32.74/21.98)	IAFMIALLLIALSVHEVHRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.72|      15|      81|     273|     287|       3
---------------------------------------------------------------------------
  273-  287 (28.85/15.05)	RLLTHVFMHYTYRDA
  355-  369 (28.86/15.06)	KILHTKLTHYPYRYA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     172.46|      43|      82|     112|     154|       4
---------------------------------------------------------------------------
   79-  108 (30.67/16.21)	....NSA......NKIVDFFVRNVIQRQMLSIKCICEKLL.......
  112-  154 (77.60/54.82)	ELNINSC..GW..NDTFAFFMENISLLDYKGVRDTLKRLLDIPIPVH
  193-  237 (64.19/43.78)	NLPEQRCfsHWrmADCFTEIIE..SFRPLAQLNSVCGRTFMTPIPGH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     218.13|      46|      83|     545|     590|       5
---------------------------------------------------------------------------
  510-  543 (42.00/24.67)	............GNFASNTTSSM.PYPNGAVSEVKLRPLK.L.....EFLDSV
  545-  590 (78.61/53.82)	VHVRMNIANSLIGTFGRFMQGKS.AWPSPALVETYCRMLT.Y.....PDLEIL
  592-  628 (41.14/23.99)	LK...QFTSHIVLTAARHQCCEM.MY.......ICCEILN.YrlfniPS....
  632-  674 (56.39/36.12)	VHAIVTLQQTL..AFAKFQTNASlYW...MLERTLLLQFQwY.....PHYEIF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     178.95|      59|      86|    1117|    1199|       7
---------------------------------------------------------------------------
 1117- 1183 (93.01/102.52)	P....FYQ..TILTtlcsdnMNsINTDVSNKL...DFE....KRSKLMED.CYPARILALCHAVWlHSTSGYLQLLPQALR
 1205- 1277 (85.94/45.56)	PflqrFYQerTKFT......MD.ITTDLYQMLynvDCEvgnwKYEDLICDfFYHVKYMYVGDSVR.QDTDRIIPMLRPSLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.44|      15|      16|    1358|    1372|       8
---------------------------------------------------------------------------
 1358- 1372 (29.55/20.85)	YWWVHTAGVSGQLSH
 1377- 1391 (30.89/22.20)	FQWTCETGPGSPSGH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.43|      17|      86|     398|     417|      12
---------------------------------------------------------------------------
  377-  393 (29.65/15.70)	LFNFLSGGMQKYSV..EEF
  399-  417 (23.78/17.51)	LYRLLYTGRDIFTVsgSDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.94|      14|      17|     819|     835|      13
---------------------------------------------------------------------------
  819-  832 (25.50/ 8.98)	MLTMLL..RDYEGNDA
  837-  852 (16.44/ 7.39)	LIVMLLvqRSEELRSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.24|      23|      24|     291|     313|      14
---------------------------------------------------------------------------
  291-  313 (40.89/23.36)	LLGTAKPEKSRI.PYFEEVI.TEII
  316-  340 (35.36/19.23)	LMFTAECDHSQLnPQAWRIIsTQII
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06381 with Med23 domain of Kingdom Metazoa
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