Description | Mediator of RNA polymerase II transcription subunit 15 (Fragment) |
Sequence | LDIFVVIISLFCYFFINLEHFFLCFLSLIMEDDWRSQRQREKVIQHLDNVIRSCTVPLNIPGDARQVENAIFLKANNQEEYMQFVSKIIYHASSGAAAMSQPQRHQAPVNQVPYGNMQPGTQFRRADMRPMQQPMQQQQQQQQQQQQQQQQQVAGQIYSGMRAPPNAEMQPRLLRPMHQASVTMHHMHQQQAAQMGQMGMTQSAGIAAAAQQQPQNVVMLLTSGNPPRQVASAPSAGQLRQPNDIQQFLQQLPPAIRQQILQLPPEEQAEQLKKFFESRRWQQQQQLHQQQQIQQQQQQQQQQQQQQQQQQQQIQQQIQHQQQQQQQQQQLQAQQQIQHQIHHVAQNQMHPQAVIQQQQQQQQQQQQQQQQQHQQHQQQFASVRQQQQMQMLQPMMQQPGAVRFADQSTMLYSRPPATPAMMPHTPAPVQQPPSQPAPVTPMSGQAASPNVNMGTPYPSSSPAGAHMMGPSPAYAAETSPVCHPVATPCPKTSQGDYYDGLFCNCYSMVFLLPVSPAAQNSLPPESIGAEHSPYKEKVNELLVYLEPLKRLIEQTKESTSDSSQTQKFQRMVDILEGRNDTSMDVLLKCEETLKMICQKSEVIKVKDRNINQPLLDAISAITKRERQKINLYEYFNFPLYQCSLKNTCVDTLNRIFSFIRKVTVFSPDCLKGMCENETAQTSNVEDSDQIGIPLNIQREIGNLESKFRVTIDPSQRPLRSSCKFISVLCELLDITLPSVPPIYIRIPTNYPQSPPKYDLEWSQYGDSPYLNSIRKSLESFSSDTGAPNTISALLTNWETCVRDASFI |
Length | 807 |
Position | Tail |
Organism | Trichinella papuae |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.701 |
Instability index | 71.96 |
Isoelectric point | 7.35 |
Molecular weight | 92262.43 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364150 |
GO - Cellular Component | integral component of membrane GO:0016021 IEA:UniProtKB-KW mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP06380 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 6| 475.95| 61| 61| 293| 353| 1 --------------------------------------------------------------------------- 76- 143 (79.67/15.21) NNQEEYMQFVSKIIYHASS.....GAAAM....SQ...PQRHQAPVNQVPYGNM...QPgtqfrradmRP...........MQQpMQQQQQQQQ 144- 193 (79.40/15.14) QQQQQQQQQVAGQI..............Y....SGMRAPPNAEMQPRLL..RPM...HQ.........AS...........VTM.HHMHQQQAA 194- 250 (73.49/13.52) QMGQMGMTQSAGIAAAAQQ.....QPQNV....VMLLTSGNPPRQVASA.........P.........SA.........gqLRQ.PNDIQQFLQ 251- 304 (67.29/11.81) QLPPAIRQQILQLPPEEQA.....EQLKKffesRRWQQQQQ............L...HQ.........QQ..........qIQQ.QQQQQQQQQ 305- 366 (111.08/23.84) QQQQQQQQQIQQQIQHQQQ.....QQQQQ....QQLQAQQQIQHQIHHVAQNQM...HP.........QA..........vIQQ.QQQQQQQQQ 367- 435 (65.02/11.19) QQQQQQHQ......QHQQQfasvrQQQQM....QMLQPMMQQPGAVRFADQSTMlysRP.........PAtpammphtpapVQQ.PPSQ..... --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 95.83| 20| 51| 461| 480| 2 --------------------------------------------------------------------------- 419- 441 (22.12/ 7.82) .PA...MMPHTPAPvqqppsqPAPVTP 461- 480 (39.71/19.88) SPAGAHMMGPSPAY.......AAETSP 515- 533 (34.01/15.97) SPAAQNSL.PPESI.......GAEHSP --------------------------------------------------------------------------- |
IDR Sequence | Start | Stop |
1) MSQPQRHQAPVNQVPYGNMQPGTQFRRADMRPMQQPMQQQQQQQQQQQQQQQQQVAGQIYSGMRAPPNAEMQPRLLRPMHQASVTMHHMHQQQAAQMGQMGMTQSAGIAAAAQQQPQNVVMLLTSGNPPRQVASAPSAGQLRQPNDIQQFLQQ 2) QQQIQHQIHHVAQNQMHPQAVIQQQQQQQQQQQQQQQQQHQQHQQQFASVRQQQQMQMLQPMMQQPGAVRFADQSTMLYSRPPATPAMMPHTPAPVQQPPSQPAPVTPMSGQAASPNVNMGTPYPSSSPAGAHMMGPSPAYAAETSPVCHPVATPC | 99 334 | 251 489 |
MoRF Sequence | Start | Stop |
NA | NA | NA |
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