<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06378

Description Mediator of RNA polymerase II transcription subunit 15 (Fragment)
SequenceLDIFVVIISLFCYFFINLEHFFLCFLSLIMEDDWRSQRQREKVIQHLDNVIRSCTVPLNIPGDARQVENAIFLKANNQEEYMQFVSKIIYHASSGAAAMSQPQRHQAPVNQVPYGNMQPGTQFRRADMRPMQQPMQQQQQQQQQQQQQQQQQVAGQIYSGMRAPPNAEMQPRLLRPMHQASVTMHHMHQQQAAQMGQMGMTQSAGIAAAAQQQPQNVVMLLTSGNPPRQVASAPSAGQLRQPNDIQQFLQQLPPAIRQQILQLPPEEQAEQLKKFFESRRWQQQQQLHQQQQIQQQQQQQQQQQQQQQQQQQQIQQQIQHQQQQQQQQQQLQAQQQIQHQIHHVAQNQMHPQAVIQQQQQQQQQQQQQQQQQHQQHQQQFASVRQQQQMQMLQPMMQQPGAVRFADQSTMLYSRPPATPAMMPHTPAPVQQPPSQPAPVTPMSGQAASPNVNMGTPYPSSSPAGAHMMGPSPAYAAETSPVCHPVATPCPKTSQVSPAAQNSLPPESIGAEHSPYKEKVNELLVYLEPLKRLIEQTKESTSDSSQTQKFQRMVDILEGRNDTSMDVLLKCEETLKMICQKSEVIKVKDRNINQPLLDAISAITKRERQKINLYEYFNFPLYQCSLKNTCPDCLKGMCENETAQTSNVEDSDQIGIPLNIQREIGNLESKFRVTIDPSQRPLRSSCKFISVLCELLDITLPSVPPIYIRIPTNYPQSPPKYDLEWSQYGDSPYLNSIRKSLESFSSDTGAPNTISALLTNWETCVRDASFI
Length770
PositionTail
OrganismTrichinella papuae
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.06
Grand average of hydropathy-0.762
Instability index74.29
Isoelectric point7.37
Molecular weight87935.42
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06378
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     475.95|      61|      61|     293|     353|       1
---------------------------------------------------------------------------
   76-  143 (79.67/15.42)	NNQEEYMQFVSKIIYHASS.....GAAAM....SQ...PQRHQAPVNQVPYGNM...QPgtqfrradmRP...........MQQpMQQQQQQQQ
  144-  193 (79.40/15.34)	QQQQQQQQQVAGQI..............Y....SGMRAPPNAEMQPRLL..RPM...HQ.........AS...........VTM.HHMHQQQAA
  194-  250 (73.49/13.64)	QMGQMGMTQSAGIAAAAQQ.....QPQNV....VMLLTSGNPPRQVASA.........P.........SA.........gqLRQ.PNDIQQFLQ
  251-  304 (67.29/11.86)	QLPPAIRQQILQLPPEEQA.....EQLKKffesRRWQQQQQ............L...HQ.........QQ..........qIQQ.QQQQQQQQQ
  305-  366 (111.08/24.46)	QQQQQQQQQIQQQIQHQQQ.....QQQQQ....QQLQAQQQIQHQIHHVAQNQM...HP.........QA..........vIQQ.QQQQQQQQQ
  367-  435 (65.02/11.20)	QQQQQQHQ......QHQQQfasvrQQQQM....QMLQPMMQQPGAVRFADQSTMlysRP.........PAtpammphtpapVQQ.PPSQ.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     123.47|      22|      55|     436|     457|       2
---------------------------------------------------------------------------
  436-  457 (41.37/24.73)	PAPVTPMSGQAASPNVNMG...TPY
  462-  474 (23.39/10.35)	PA.....GAHMMGP....S...PAY
  475-  491 (29.40/15.16)	AAETSPVCHPVATP........CPK
  492-  515 (29.31/15.09)	TSQVSP.AAQNSLPPESIGaehSPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.67|      51|      56|     565|     619|       3
---------------------------------------------------------------------------
  543-  595 (81.98/70.92)	SSQTQKFQRMVDILEGRNDTsmDVLLK..CEETLKMICQK..SEVIKVKDRN.INQPL
  600-  657 (73.69/52.48)	SAITKRERQKINLYEYFNFPlyQCSLKntCPDCLKGMCENetAQTSNVEDSDqIGIPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06378 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSQPQRHQAPVNQVPYGNMQPGTQFRRADMRPMQQPMQQQQQQQQQQQQQQQQQVAGQIYSGMRAPPNAEMQPRLLRPMHQASVTMHHMHQQQAAQMGQMGMTQSAGIAAAAQQQPQNVVMLLTSGNPPRQVASAPSAGQLRQPNDIQQFLQQ
2) QQQIQHQIHHVAQNQMHPQAVIQQQQQQQQQQQQQQQQQHQQHQQQFASVRQQQQMQMLQPMMQQPGAVRFADQSTMLYSRPPATPAMMPHTPAPVQQPPSQPAPVTPMSGQAASPNVNMGTPYPSSSPAGAHMMGPSPAYAAETSPVCHPVATPCPKTSQVSPAAQNSLPPESIGAEHSP
99
334
251
514










Molecular Recognition Features






MoRF SequenceStartStop




NANANA