<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06360

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMFYCITGFYSFIVMSLSLSDFETKVKNLFKEHAKSGIAYFFFRPYLMTSSEECEKKIIILTANELVEIFTSVPQNLQESAFSIVISHRVLSNSANKIVDFFVRDVTQRQILSIKCICEKLLTCAELNINSCGWNDTFAFFMENISLLDYKGVRDTLKRLLDIPIPVHLQVDQRKSVEAVEKLIKTICDRKNNLLPAYFVITEIIKNLPEQRCFSHWRMADCFTEIIESFRPLAQLNSVCGRTFMTPIPGHVGFYFNAFWKLEALSLRFPLKGLLPYSQDLLNPQMRLLTHVFMHYTYRDAIAVLLGTAKPEKSRIPYFEEVITEIILELMFTAECDHSQLNPQAWRIISTQIIYLTLQQSICFTRLVKILHTKLTHYPYRYARNQLMWCLFNFLSGGMQKYSVEEFAVILDLYRLLYTGRDIFTVSGSDSSCVLMLAPTCIWIHILKKSPSMEVELPPTVNTQRKFLQEALKNKTQFNTDNYMVAVLCNAYSSTSEIFQQDLLPILLENLDNARGHNSTQASGNFASNATTNSMSYPNGTVSEVKLRPLKLEFLDSVSVHVRMNIANSLIGTFGRFMQGKSAWPSPALVETYCRMLTYADLEILGLKQFTSHIVLTAARHQCCEMMYICCEILNYRLFNIPSTYRVHAIVTLQQTLAFAKFQTNASLYWMLERTLLLQFQWYPHYEIFQAPFARLLNSFVAVAADGTRQSIAENEELMRIIILTLARSTVISSNSDSCFIEGVYRELLNKLPSYSWPQSTLSVFPQVFCSHYTQQQQQQQQQQQQQQQQQQQQQQPQQQQQPQPQQSNIVGSSQQQQQQQQQQQQQQQSHFLLKQQVDEEYIKHRTFGSELSLIDYFTNTSTSTVYLCLLWRLVYDTGELPAVSMKILEVLGPRKVLIHLKSLADFLVYETNSADVNRCVDVLNRLIFKYAVVPLERFMLTMLLRDYEGNDAFYALLIVMLLVQRSEELRSAVADCVAMLPSDYWHCQDWNDKYQAYQLKHAERTWSQVHTELSRASLTPNDCPLPVYFGTRCLQMLPVVDLLLQKLVESPAACLKFLDSTLSILGPLYRFHPYPVSFLYSTFRFYEKRLVEAPAIKQKLALAVHGACVPSRDDHWLLSAEFVSCVGSGPVTDRGPWVPDLNYYAALVRRLMDTFSEPRQQWSRKSDLRFVEFNNFQTHALYCICIELMSLSVSVVDVGNALITLVTHWHSLVDKNTVMYWVNAIGLIFSALPISYMEPFYQTILTTLCSDHMNSMNTDVSNKLDFEKRSKLMEDCYPARILALCHAVWLHSASGYLQLLPQALRSTWIPHVRSEGQFLYVCHLVAPFLQRFYQERTKFTMDITTDLYQMLYNVDCEVSSWKYEDLICDFFYHVKYMYVGDSVRQETDRIIPMLRTSLQQKLRYISFAQGEQSGTPFSEMINPIKLLGIQMVVWLQQLPIFGETAQHFWLAVTKLGDPVMTFSLYFPALFPFFGTAAVDMVIVGAFSEICNCVLKWILLDDRPYWWVHTAGVSGQLSHPLKQFQWTCETGPGSPSGHAMVSASVWFNLLYNLQSDLVLGDLSGCLCWLLYVVFLIAVSISRTYISAHFPDQVILGIVVGICIALVTRSLVGHRRRRWSNLIAFMIALLLIALSVHEAHRFLGVDTHRSIELAAKYCHRAEWIHQSTTPLASFFRDVGVLISIAMLLANKSMHTNNNNNNITSKPFSSKFAQALLGVGLNQLVALIPIGRLPIALFYAVLLPIVSICCFVVNMVLDLDNFRVEKGGNVQAVRISQQKRFQSVDLVDQVVETDQEWRRSRYLSDEWNRLKNLCSKEIGEKIKRKEPVHGDSTLPDSLTDKLQKVTVDQIRALSVSQIKQLRLLIDHEMEKSDKLVENLEAVRFKALSQIGNLVHNSVPVSENEDDNEIVRTWGELEVRKKYSQVDLGIMVDGYDSERGCSVAGSRGYFLKGPLVFLEQALIQLAMHMLYKKKYTPLYTPFFMRKEVMQEVAQLSDFDDQLYKVIGKSSEVKEDIAEEEKYLIATSEQPIAAYHRDEWISKESLPLRYIGFSTCFRQEVGSHGRDTSGIFRVHQFEKVEQFCITSPHDDASWEMLEEMILNAEMFYQTLNIPYRVVSIVSGELNNAAAKKYDLEAWFPGSGAFRELVSCSNCTDYQSRRLRIRYEFVHMLNGTMCATTRTICAILENFQEENGIVVPEALRPYMPDDYKDFIPFVKAAPKVDQQAAKRGNKSATEKSTHYVRSNSKYAQEFCRTLFVCSLSLNVAHQSGAIGCLGWFLEFCIILPRTFTACTILAVDRYGPVDRFLCLNLLLQSRTRFYKFAAVVNLRRCGCRQIFLLRTCKPAFSGQWFTLATAGNATVVDS
Length2360
PositionTail
OrganismTrichinella papuae
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.11
Grand average of hydropathy-0.020
Instability index45.64
Isoelectric point7.17
Molecular weight270955.06
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-KW
serine-tRNA ligase activity	GO:0004828	IEA:UniProtKB-EC

GO - Biological Process
seryl-tRNA aminoacylation	GO:0006434	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06360
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.57|      34|      34|     765|     798|       1
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  757-  795 (64.03/39.78)	PQStlsvfPQVFCSHYTQQQQQQQQQQQQQQQQQQQ....QQQ
  796-  836 (56.54/34.24)	PQQ..qqqPQPQQSNIVGSSQQQQQQQQQQQQQQQShfllKQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     492.53|     143|     651|    1119|    1351|       2
---------------------------------------------------------------------------
  411-  482 (71.60/15.46)	................................................................................................DLY..R...LLYTGRDIFTVSGSDSSCVLMLAPTCIWI.HILKKSPSMEV..ELPPTVntQR.kFLQEALKNKTQFNTDNY...
 1191- 1351 (229.23/280.19)	LSVSVVdvgNALITLVTHWHSLVDK.....NTVMY.WVNAIG.LIFSALPISYMEpfyqtilttlcsDHMNSMNTdvSNKLDFEKR.SK....LMEDCYPAR...ILALCHAVWLHSASGYLQLLPQALRSTWIpHVRSEGQFLYVCHLVAPFL..QR..FYQERTKFTMDITTDLYQML
 1850- 2002 (191.70/97.67)	LSVSQI...KQLRLLIDHEMEKSDKlvenlEAVRFkALSQIGnLVHNSVPVSENE............DDNEIVRT..WGELEVRKKySQvdlgIMVDGYDSErgcSVAGSRGYFL...KGPLVFLEQALIQLAM.HMLYKKKY...TPLYTPFF..MRkeVMQEVAQLS.DFDDQLYKVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.79|      32|     230|    1799|    1830|       3
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 1799- 1830 (57.85/38.26)	YLSDEWNRLKNLCSKEIGEKIKRKEPV..HGDST
 2030- 2063 (55.94/36.73)	YHRDEWISKESLPLRYIGFSTCFRQEVgsHGRDT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.06|      27|      31|    1438|    1464|       4
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 1438- 1464 (48.38/29.25)	LPIFGETAQHFWL..AVTKLGDPVMTFSL
 1470- 1498 (41.42/23.91)	FPFFGTAAVDMVIvgAFSEICNCVLKWIL
 1518- 1534 (26.26/12.27)	HPL....KQFQWT..CETGPGSP......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.81|      33|      80|     947|     982|       5
---------------------------------------------------------------------------
  947-  982 (51.97/41.31)	YEGNDAFYALLIVMLLVQRseeLRSAVADCVAMLPS
 1028- 1060 (58.84/38.76)	YFGTRCLQMLPVVDLLLQK...LVESPAACLKFLDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.72|      15|      80|     286|     300|       6
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  286-  300 (28.85/18.28)	RLLTHVFMHYTYRDA
  368-  382 (28.86/18.29)	KILHTKLTHYPYRYA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.13|      41|      84|     125|     167|       7
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  125-  167 (70.99/49.30)	ELNINSC..GW..NDTFAFFMEniSLLDYKGVRDTLKRLLDIPIPVH
  206-  250 (68.14/41.53)	NLPEQRCfsHWrmADCFTEIIE..SFRPLAQLNSVCGRTFMTPIPGH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.22|      26|      32|    2247|    2276|       8
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 2247- 2274 (43.57/29.79)	EFC....RTLFVCSLsLNVaHQSGAIG...CLGWF
 2276- 2308 (39.65/24.07)	EFCiilpRTFTACTI.LAV.DRYGPVDrflCLNLL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06360 with Med23 domain of Kingdom Metazoa
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