<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06358

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMFYCITGFYSFIVMSLSLSDFETKVKNLFKEHAKSGIAYFFFRPYLMTSSEECEKKIIILTANELVEIFTSVPQNLQESAFSIVISHRVLSNSANKIVDFFVRDVTQRQILSIKCICEKLLTCAELNINSCGWNDTFAFFMENISLLDYKGVRDTLKRLLDIPIPVHLQVDQRKSVEAVEKLIKTICDRKNNLLPAYFVITEIIKNLPEQRCFSHWRMADCFTEIIESFRPLAQLNSVCGRTFMTPIPGHVGFYFNAFWKLEALSLRFPLKGLLPYSQDLLNPQMRLLTHVFMHYTYRDAIAVLLGTAKPEKSRIPYFEEVITEIILELMFTAECDHSQLNPQAWRIISTQIIYLTLQQSICFTRLVKILHTKLTHYPYRYARNQLMWCLFNFLSGGMQKYSVEEFAVILDLYRLLYTGRDIFTVSGSDSSCVLMLAPTCIWIHILKKSPSMEVELPPTVNTQRKFLQEALKNKTQFNTDNYMVAFFCIKLDQKNLKFSDSSTSEIFQQDLLPILLENLDNARGHNSTQASGNFASNATTNSMSYPNGTVSEVKLRPLKLEFLDSVSVHVRMNIANSLIGTFGRFMQGKSAWPSPALVETYCRMLTYADLEILGLKQFTSHIVLTAARHQCCEMMYICCEILNYRLFNIPSTYRVHAIVTLQQTLAFAKFQTNASLYWMLERTLLLQFQWYPHYEIFQAPFARLLNSFVAVAADGTRQSIAENEELMRIIILTLARSTVISSNSDSCFIEGVYRELLNKLPSYSWPQSTLSVFPQVFCSHYTQQQQQQQQQQQQQQQQQQQQQQPQQQQQPQPQQSNIVGSSQQQQQQQQQQQQQQQSHFLLKQQVDEEYIKHRTFGSELSLIDYFTNTSTSTVYLCLLWRLVYDTGELPAVSMKILEVLGPRKVLIHLKSLADFLVYETNSADVNRCVDVLNRLIFKYAVVPLERFMLTMLLRDYEGNDAFYALLIVMLLVQRSEELRSAVADCVAMLPSDYWHCQDWNDKYQAYQLKHAERTWSQVHTELSRASLTPNDCPLPVYFGTRCLQMLPVVDLLLQKLVESPAACLKFLDSTLSILGPLYRFHPYPVSFLYSTFRFYEKRLVEAPAIKQKLALAVHGACVPSRDDHWLLSAEFVSCVGSGPVTDRGPWVPDLNYYAALVRRLMDTFSEPRQQWSRKSDLRFVEFNNFQTHALYCICIELMSLSVSVVDVGNALITLVTHWHSLVDKNTVMYWVNAIGLIFSALPISYMEPFYQTILTTLCSDHMNSMNTDVSNKLDFEKRSKLMEDCYPARILALCHAVWLHSASGYLQLLPQALRSTWIPHVRSEGQFLYVCHLVAPFLQRFYQERTKFTMDITTDLYQMLYNVDCEVSSWKYEDLICDFFYHVKYMYVGDSVRQETDRIIPMLRTSLQQKLRYISFAQGEQSGTPFSGLLILKLKSNLFYEFILLDRFYTCRRSWYSFGVAVFQKLWKIEFYSYFYAHRNDQSDKIVGNSDGCMASTIAHIWRNGAAFLARGDQTGRSGNDIFSLLSSFVSIFWHRGSGYGYCWCFQILLDDRPYWWVHTAGVSGQLSHPLKQFQWTCETGPGSPSGHAMVSASVWFNLLYNLQSDLVLGDLSGCLCWLLYVVFLIAVSISRTYISAHFPDQVILGIVVGICIALVTRSLVGHRRRRWSNLIAFMIALLLIALSVHEAHRFLGVDTHRSIELAAKYCHRAEWIHQSTTPLASFFRDVGVLISIAMLLANKSMHTNNNNNNITSKPFSSKFAQALLGVGLNQLVALIPIGRLPIALFYAVLLPIVSICCFVVNMVLDLDNFRVEKGGNVQAVRISQQKRFQSVDLVDQVVETDQEWRRSRYLSDEWNRLKNLCSKEIGEKIKRKEPVHGDSTLPDSLTDKLQKVTVDQIRALSVSQIKQLRLLIDHEMEKSDKLVENLEAVRFKALSQIGNLVHNSVPVSENEDDNEIVRTWGELEVRKKYSQVDLGIMVDGYDSERGCSVAGSRGYFLKGPLVFLEQALIQLAMHMLYKKKYTPLYTPFFMRKEVMQEVAQLSDFDDQLYKVIGKSSEVKEDIAEEEKYLIATSEQPIAAYHRDEWISKESLPLRYIGFSTCFRQEVGSHGRDTSGIFRVHQFEKVEQFCITSPHDDASWEMLEEMILNAEMFYQTLNIPYRVVSIVSGELNNAAAKKYDLEAWFPGSGAFRELVSCSNCTDYQSRRLRIRYEFVHMLNGTMCATTRTICAILENFQEENGIVVPEALRPYMPDDYKDFIPFVKAAPKVDQQAAKRGNKSATEKSTHYVRSNSKYAQEFCRTLFVCSLSLNVAHQSGAIGCLGWFLEFCIILPRTFTACTILAVDRYGPVDRFLCLNLLLQSRTRFYKFAAVVNLRRCGCRQIFLLRTCKPAFSGQWFTLATAGNATVVDS
Length2411
PositionTail
OrganismTrichinella papuae
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.12
Grand average of hydropathy-0.054
Instability index46.08
Isoelectric point7.85
Molecular weight277329.75
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-KW
serine-tRNA ligase activity	GO:0004828	IEA:UniProtKB-EC

GO - Biological Process
seryl-tRNA aminoacylation	GO:0006434	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06358
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.57|      34|      34|     774|     807|       1
---------------------------------------------------------------------------
  766-  804 (64.03/39.03)	PQStlsvfPQVFCSHYTQQQQQQQQQQQQQQQQQQQ....QQQ
  805-  845 (56.54/33.61)	PQQ..qqqPQPQQSNIVGSSQQQQQQQQQQQQQQQShfllKQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.96|      29|     119|     177|     207|       2
---------------------------------------------------------------------------
  177-  207 (42.76/36.99)	EAVEKLIKTICDRKNNlLPaYF..VITEIIKNL
  299-  329 (45.20/29.29)	DAIAVLLGTAKPEKSR.IP.YFeeVITEIILEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.12|      40|     943|     375|     417|       3
---------------------------------------------------------------------------
  375-  417 (71.16/48.14)	THYPYRYARNQLMW.C..LFNFLSGGMQ...KYSVEefaVILDLYRLLY
 1316- 1361 (62.96/35.27)	TWIPHVRSEGQFLYvChlVAPFLQRFYQertKFTMD...ITTDLYQMLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     319.30|     118|     538|     984|    1125|       4
---------------------------------------------------------------------------
  878- 1042 (176.16/108.94)	LLWRLVydtgELPAVSMKILE....VLGPrkvLIHLKSLADFLVYETNSADVNRCVD...VLNRLIFKY..AVVPL..ERF.......................................................................................................................................................................................................................................................................................................................................................................mltmllrdyegndafyallivmllvqrseelrsavaDCVAMLP...SDYWHCQDWNDKYQAYQLKHAERTWSQVHTELSRASLTPndcPLPvYFGTRC
 1052- 1125 (67.12/49.64)	LLQKLV....ESPAACLKFLDstlsILGP...LYRFHPYPVSFLYSTFRFYEKRLVEapaIKQKLALAVhgACVPSrdDHW.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1521- 1578 (76.02/28.15)	.................................................................................llsaefvscvgsgpvtdrgpwvpdlnyyaalvrrlmdtfseprqqwsrksdlrfvefnnfqthalycicielmslsvsvvdvgnalitlvthwhslvdkntvmywvnaiglifsalpisymepfyqtilttlcsdhmnsmntdvsnkldfekrsklmedcyparilalchavwlhsasgylqllpqalrstwiphvrsegqflyvchlvapflqrfyqertkftmdittdlyqmlynvdcevsswkyedlicdffyhvkymyvgdsvrqetdriipmlrtslqqklryisfaqgeqsgtpfsgllilklksnlfyefilldrfytcrrswysfgvavfqklwkiefysyfyahrndqsdkivgnsdgcmastiahiwrngaaflargdqtgrsgnDIFSLLSsfvSIFWHRGSGYGYCWCFQILLDDRPYWWVHTAGVSGQLSH...PLK.QFQWTC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.05|      20|     120|    1472|    1494|       5
---------------------------------------------------------------------------
 1472- 1494 (34.71/30.25)	YSYFYahrNDQSDKIVGNSDGCM
 1597- 1616 (36.34/22.39)	FNLLY...NLQSDLVLGDLSGCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     242.16|      72|     538|    1739|    1810|       6
---------------------------------------------------------------------------
 1739- 1810 (122.75/83.93)	NKSMHTNNNNNNITSKPFSSKFAQALLGVGLNQLVALI..PIGRLPIALFYAVLLPIVSICCFV..VNMVLDLDNF
 2278- 2353 (119.42/81.42)	NKSATEKSTHYVRSNSKYAQEFCRTLFVCSLSLNVAHQsgAIGCLGWFLEFCIILPRTFTACTIlaVDRYGPVDRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.20|      13|      34|    1246|    1258|       9
---------------------------------------------------------------------------
 1246- 1258 (25.37/16.41)	MEPFYQTILTTLC
 1282- 1294 (25.84/16.87)	MEDCYPARILALC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.03|      11|      34|     602|     612|      10
---------------------------------------------------------------------------
  602-  612 (20.36/10.56)	CRMLTYADLEI
  639-  649 (20.67/10.84)	CEILNYRLFNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.79|      32|     230|    1850|    1881|      11
---------------------------------------------------------------------------
 1850- 1881 (57.85/38.01)	YLSDEWNRLKNLCSKEIGEKIKRKEPV..HGDST
 2081- 2114 (55.94/36.49)	YHRDEWISKESLPLRYIGFSTCFRQEVgsHGRDT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.04|      19|     543|    1443|    1466|      19
---------------------------------------------------------------------------
 1416- 1434 (31.96/18.62)	FAQGEQSGTPFSGLLILKL
 1448- 1466 (36.08/16.03)	FYTCRRSWYSFGVAVFQKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.10|      14|      17|     948|     961|      24
---------------------------------------------------------------------------
  948-  961 (25.40/16.58)	MLTMLL..RDYEGNDA
  966-  981 (17.70/ 9.16)	LIVMLLvqRSEELRSA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06358 with Med23 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QQQQQQQQQQQQQQQQPQQQQQPQPQQSNIVGSSQQQQQ
789
827










Molecular Recognition Features






MoRF SequenceStartStop




NANANA