<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06358

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMFYCITGFYSFIVMSLSLSDFETKVKNLFKEHAKSGIAYFFFRPYLMTSSEECEKKIIILTANELVEIFTSVPQNLQESAFSIVISHRVLSNSANKIVDFFVRDVTQRQILSIKCICEKLLTCAELNINSCGWNDTFAFFMENISLLDYKGVRDTLKRLLDIPIPVHLQVDQRKSVEAVEKLIKTICDRKNNLLPAYFVITEIIKNLPEQRCFSHWRMADCFTEIIESFRPLAQLNSVCGRTFMTPIPGHVGFYFNAFWKLEALSLRFPLKGLLPYSQDLLNPQMRLLTHVFMHYTYRDAIAVLLGTAKPEKSRIPYFEEVITEIILELMFTAECDHSQLNPQAWRIISTQIIYLTLQQSICFTRLVKILHTKLTHYPYRYARNQLMWCLFNFLSGGMQKYSVEEFAVILDLYRLLYTGRDIFTVSGSDSSCVLMLAPTCIWIHILKKSPSMEVELPPTVNTQRKFLQEALKNKTQFNTDNYMVAFFCIKLDQKNLKFSDSSTSEIFQQDLLPILLENLDNARGHNSTQASGNFASNATTNSMSYPNGTVSEVKLRPLKLEFLDSVSVHVRMNIANSLIGTFGRFMQGKSAWPSPALVETYCRMLTYADLEILGLKQFTSHIVLTAARHQCCEMMYICCEILNYRLFNIPSTYRVHAIVTLQQTLAFAKFQTNASLYWMLERTLLLQFQWYPHYEIFQAPFARLLNSFVAVAADGTRQSIAENEELMRIIILTLARSTVISSNSDSCFIEGVYRELLNKLPSYSWPQSTLSVFPQVFCSHYTQQQQQQQQQQQQQQQQQQQQQQPQQQQQPQPQQSNIVGSSQQQQQQQQQQQQQQQSHFLLKQQVDEEYIKHRTFGSELSLIDYFTNTSTSTVYLCLLWRLVYDTGELPAVSMKILEVLGPRKVLIHLKSLADFLVYETNSADVNRCVDVLNRLIFKYAVVPLERFMLTMLLRDYEGNDAFYALLIVMLLVQRSEELRSAVADCVAMLPSDYWHCQDWNDKYQAYQLKHAERTWSQVHTELSRASLTPNDCPLPVYFGTRCLQMLPVVDLLLQKLVESPAACLKFLDSTLSILGPLYRFHPYPVSFLYSTFRFYEKRLVEAPAIKQKLALAVHGACVPSRDDHWLLSAEFVSCVGSGPVTDRGPWVPDLNYYAALVRRLMDTFSEPRQQWSRKSDLRFVEFNNFQTHALYCICIELMSLSVSVVDVGNALITLVTHWHSLVDKNTVMYWVNAIGLIFSALPISYMEPFYQTILTTLCSDHMNSMNTDVSNKLDFEKRSKLMEDCYPARILALCHAVWLHSASGYLQLLPQALRSTWIPHVRSEGQFLYVCHLVAPFLQRFYQERTKFTMDITTDLYQMLYNVDCEVSSWKYEDLICDFFYHVKYMYVGDSVRQETDRIIPMLRTSLQQKLRYISFAQGEQSGTPFSGLLILKLKSNLFYEFILLDRFYTCRRSWYSFGVAVFQKLWKIEFYSYFYAHRNDQSDKIVGNSDGCMASTIAHIWRNGAAFLARGDQTGRSGNDIFSLLSSFVSIFWHRGSGYGYCWCFQILLDDRPYWWVHTAGVSGQLSHPLKQFQWTCETGPGSPSGHAMVSASVWFNLLYNLQSDLVLGDLSGCLCWLLYVVFLIAVSISRTYISAHFPDQVILGIVVGICIALVTRSLVGHRRRRWSNLIAFMIALLLIALSVHEAHRFLGVDTHRSIELAAKYCHRAEWIHQSTTPLASFFRDVGVLISIAMLLANKSMHTNNNNNNITSKPFSSKFAQALLGVGLNQLVALIPIGRLPIALFYAVLLPIVSICCFVVNMVLDLDNFRVEKGGNVQAVRISQQKRFQSVDLVDQVVETDQEWRRSRYLSDEWNRLKNLCSKEIGEKIKRKEPVHGDSTLPDSLTDKLQKVTVDQIRALSVSQIKQLRLLIDHEMEKSDKLVENLEAVRFKALSQIGNLVHNSVPVSENEDDNEIVRTWGELEVRKKYSQVDLGIMVDGYDSERGCSVAGSRGYFLKGPLVFLEQALIQLAMHMLYKKKYTPLYTPFFMRKEVMQEVAQLSDFDDQLYKVIGKSSEVKEDIAEEEKYLIATSEQPIAAYHRDEWISKESLPLRYIGFSTCFRQEVGSHGRDTSGIFRVHQFEKVEQFCITSPHDDASWEMLEEMILNAEMFYQTLNIPYRVVSIVSGELNNAAAKKYDLEAWFPGSGAFRELVSCSNCTDYQSRRLRIRYEFVHMLNGTMCATTRTICAILENFQEENGIVVPEALRPYMPDDYKDFIPFVKAAPKVDQQAAKRGNKSATEKSTHYVRSNSKYAQEFCRTLFVCSLSLNVAHQSGAIGCLGWFLEFCIILPRTFTACTILAVDRYGPVDRFLCLNLLLQSRTRFYKFAAVVNLRRCGCRQIFLLRTCKPAFSGQWFTLATAGNATVVDS
Length2411
PositionTail
OrganismTrichinella papuae
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.12
Grand average of hydropathy-0.054
Instability index46.08
Isoelectric point7.85
Molecular weight277329.75
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-KW
serine-tRNA ligase activity	GO:0004828	IEA:UniProtKB-EC

GO - Biological Process
seryl-tRNA aminoacylation	GO:0006434	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06358
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.57|      34|      34|     774|     807|       1
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  766-  804 (64.03/39.03)	PQStlsvfPQVFCSHYTQQQQQQQQQQQQQQQQQQQ....QQQ
  805-  845 (56.54/33.61)	PQQ..qqqPQPQQSNIVGSSQQQQQQQQQQQQQQQShfllKQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.96|      29|     119|     177|     207|       2
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  177-  207 (42.76/36.99)	EAVEKLIKTICDRKNNlLPaYF..VITEIIKNL
  299-  329 (45.20/29.29)	DAIAVLLGTAKPEKSR.IP.YFeeVITEIILEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.12|      40|     943|     375|     417|       3
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  375-  417 (71.16/48.14)	THYPYRYARNQLMW.C..LFNFLSGGMQ...KYSVEefaVILDLYRLLY
 1316- 1361 (62.96/35.27)	TWIPHVRSEGQFLYvChlVAPFLQRFYQertKFTMD...ITTDLYQMLY
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     319.30|     118|     538|     984|    1125|       4
---------------------------------------------------------------------------
  878- 1042 (176.16/108.94)	LLWRLVydtgELPAVSMKILE....VLGPrkvLIHLKSLADFLVYETNSADVNRCVD...VLNRLIFKY..AVVPL..ERF.......................................................................................................................................................................................................................................................................................................................................................................mltmllrdyegndafyallivmllvqrseelrsavaDCVAMLP...SDYWHCQDWNDKYQAYQLKHAERTWSQVHTELSRASLTPndcPLPvYFGTRC
 1052- 1125 (67.12/49.64)	LLQKLV....ESPAACLKFLDstlsILGP...LYRFHPYPVSFLYSTFRFYEKRLVEapaIKQKLALAVhgACVPSrdDHW.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1521- 1578 (76.02/28.15)	.................................................................................llsaefvscvgsgpvtdrgpwvpdlnyyaalvrrlmdtfseprqqwsrksdlrfvefnnfqthalycicielmslsvsvvdvgnalitlvthwhslvdkntvmywvnaiglifsalpisymepfyqtilttlcsdhmnsmntdvsnkldfekrsklmedcyparilalchavwlhsasgylqllpqalrstwiphvrsegqflyvchlvapflqrfyqertkftmdittdlyqmlynvdcevsswkyedlicdffyhvkymyvgdsvrqetdriipmlrtslqqklryisfaqgeqsgtpfsgllilklksnlfyefilldrfytcrrswysfgvavfqklwkiefysyfyahrndqsdkivgnsdgcmastiahiwrngaaflargdqtgrsgnDIFSLLSsfvSIFWHRGSGYGYCWCFQILLDDRPYWWVHTAGVSGQLSH...PLK.QFQWTC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.05|      20|     120|    1472|    1494|       5
---------------------------------------------------------------------------
 1472- 1494 (34.71/30.25)	YSYFYahrNDQSDKIVGNSDGCM
 1597- 1616 (36.34/22.39)	FNLLY...NLQSDLVLGDLSGCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     242.16|      72|     538|    1739|    1810|       6
---------------------------------------------------------------------------
 1739- 1810 (122.75/83.93)	NKSMHTNNNNNNITSKPFSSKFAQALLGVGLNQLVALI..PIGRLPIALFYAVLLPIVSICCFV..VNMVLDLDNF
 2278- 2353 (119.42/81.42)	NKSATEKSTHYVRSNSKYAQEFCRTLFVCSLSLNVAHQsgAIGCLGWFLEFCIILPRTFTACTIlaVDRYGPVDRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.20|      13|      34|    1246|    1258|       9
---------------------------------------------------------------------------
 1246- 1258 (25.37/16.41)	MEPFYQTILTTLC
 1282- 1294 (25.84/16.87)	MEDCYPARILALC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.03|      11|      34|     602|     612|      10
---------------------------------------------------------------------------
  602-  612 (20.36/10.56)	CRMLTYADLEI
  639-  649 (20.67/10.84)	CEILNYRLFNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.79|      32|     230|    1850|    1881|      11
---------------------------------------------------------------------------
 1850- 1881 (57.85/38.01)	YLSDEWNRLKNLCSKEIGEKIKRKEPV..HGDST
 2081- 2114 (55.94/36.49)	YHRDEWISKESLPLRYIGFSTCFRQEVgsHGRDT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.04|      19|     543|    1443|    1466|      19
---------------------------------------------------------------------------
 1416- 1434 (31.96/18.62)	FAQGEQSGTPFSGLLILKL
 1448- 1466 (36.08/16.03)	FYTCRRSWYSFGVAVFQKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.10|      14|      17|     948|     961|      24
---------------------------------------------------------------------------
  948-  961 (25.40/16.58)	MLTMLL..RDYEGNDA
  966-  981 (17.70/ 9.16)	LIVMLLvqRSEELRSA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06358 with Med23 domain of Kingdom Metazoa
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