<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06357

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMFYCITGFYSFIVMSLSLSDFETKVKNLFKEHAKSGIAYFFFRPYLMTSSEECEKKIIILTANELVEIFTSVPQNLQESAFSIVISHRVLSNSANKIVDFFVRDVTQRQILSIKCICEKLLTCAELNINSCGWNDTFAFFMENISLLDYKGVRDTLKRLLDIPIPVHLQVDQRKSVEAVEKLIKTICDRKNNLLPAYFVITEIIKNLPEQRCFSHWRMADCFTEIIESFRPLAQLNSVCGRTFMTPIPGHVGFYFNAFWKLEALSLRFPLKGLLPYSQDLLNPQMRLLTHVFMHYTYRDAIAVLLGTAKPEKSRIPYFEEVITEIILELMFTAECDHSQLNPQAWRIISTQIIYLTLQQSICFTRLVKILHTKLTHYPYRYARNQLMWCLFNFLSGGMQKYSVEEFAVILDLYRLLYTGRDIFTVSGSDSSCVLMLAPTCIWIHILKKSPSMEVELPPTVNTQRKFLQEALKNKTQFNTDNYMVAVLCNAYSSTSEIFQQDLLPILLENLDNARGHNSTQASGNFASNATTNSMSYPNGTVSEVKLRPLKLEFLDSVSVHVRMNIANSLIGTFGRFMQGKSAWPSPALVETYCRMLTYADLEILGLKQFTSHIVLTAARHQCCEMMYICCEILNYRLFNIPSTYRVHAIVTLQQTLAFAKFQTNASLYWMLERTLLLQFQWYPHYEIFQAPFARLLNSFVAVAADGTRQSIAENEELMRIIILTLARSTVISSNSDSCFIEGVYRELLNKLPSYSWPQSTLSVFPQQQQQPQPQQSNIVGSSQQQQQQQQQQQQQQQSHFLLKQQVDEEYIKHRTFGSELSLIDYFTNTSTSTVYLCLLWRLVYDTGELPAVSMKILEVLGPRKVLIHLKSLADFLVYETNSADVNRCVDVLNRLIFKYAVVPLERFMLTMLLRDYEGNDAFYALLIVMLLVQRSEELRSAVADCVAMLPSDYWHCQDWNDKYQAYQLKHAERTWSQVHTELSRASLTPNDCPLPVYFGTRCLQMLPVVDLLLQKLVESPAACLKFLDSTLSILGPLYRFHPYPVSFLYSTFRFYEKRLVEAPAIKQKLALAVHGACVPSRDDHWLLSAEFVSCVGSGPVTDRGPWVPDLNYYAALVRRLMDTFSEPRQQWSRKSDLRFVEFNNFQTHALYCICIELMSLSVSVVDVGNALITLVTHWHSLVDKNTVMYWVNAIGLIFSALPISYMEPFYQTILTTLCSDHMNSMNTDVSNKLDFEKRSKLMEDCYPARILALCHAVWLHSASGYLQLLPQALRSTWIPHVRSEGQFLYVCHLVAPFLQRFYQERTKFTMDITTDLYQMLYNVDCEVSSWKYEDLICDFFYHVKYMYVGDSVRQETDRIIPMLRTSLQQKLRYISFAQGEQSGTPFSEMINPIKLLGIQMVVWLQQLPIFGETAQHFWLAVTKLGDPVMTFSLYFPALFPFFGTAAVDMVIVGAFSEICNCVLKWILLDDRPYWWVHTAGVSGQLSHPLKQFQWTCETGPGSPSGHAMVSASVWFNLLYNLQSDLVLGDLSGCLCWLLYVVFLIAVSISRTYISAHFPDQVILGIVVGICIALVTRSLVGHRRRRWSNLIAFMIALLLIALSVHEAHRFLGVDTHRSIELAAKYCHRAEWIHQSTTPLASFFRDVGVLISIAMLLANKSMHTNNNNNNITSKPFSSKFAQALLGVGLNQLVALIPIGRLPIALFYAVLLPIVSICCFVVNMVLDLDNFRVEKGGNVQAVRISQQKRFQSVDLVDQVVETDQEWRRSRYLSDEWNRLKNLCSKEIGEKIKRKEPVHGDSTLPDSLTDKLQKVTVDQIRALSVSQIKQLRLLIDHEMEKSDKLVENLEAVRFKALSQIGNLVHNSVPVSENEDDNEIVRTWGELEVRKKYSQVDLGIMVDGYDSERGCSVAGSRGYFLKGPLVFLEQALIQLAMHMLYKKKYTPLYTPFFMRKEVMQEVAQLSDFDDQLYKVIGKSSEVKEDIAEEEKYLIATSEQPIAAYHRDEWISKESLPLRYIGFSTCFRQEVGSHGRDTSGIFRVHQFEKVEQFCITSPHDDASWEMLEEMILNAEMFYQTLNIPYRVVSIVSGELNNAAAKKYDLEAWFPGSGAFRELVSCSNCTDYQSRRLRIRYEFVHMLNGTMCATTRTICAILENFQEENGIVVPEALRPYMPDDYKDFIPFVKAAPKVDQQAAKRGNKSATEKSTHYVRSNSKYAQEFCRTLFVCSLSLNVAHQSGAIGCLGWFLEFCIILPRTFTACTILAVDRYGPVDRFLCLNLLLQSRTRFYKFAAVVNLRRCGCRQIFLLRTCKPAFSGQWFTLATAGNATVVDS
Length2329
PositionTail
OrganismTrichinella papuae
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.11
Grand average of hydropathy0.014
Instability index44.13
Isoelectric point7.17
Molecular weight267073.03
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-KW
serine-tRNA ligase activity	GO:0004828	IEA:UniProtKB-EC

GO - Biological Process
seryl-tRNA aminoacylation	GO:0006434	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06357
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.22|      26|      31|    2216|    2245|       1
---------------------------------------------------------------------------
 2216- 2243 (43.57/33.69)	EFC....RTLFVCSLsLNVaHQSGAIG...CLGWF
 2245- 2277 (39.65/27.25)	EFCiilpRTFTACTI.LAV.DRYGPVDrflCLNLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.54|      18|      20|     766|     783|       2
---------------------------------------------------------------------------
  766-  783 (34.41/21.33)	QQQQQPQPQQSNIVGSSQ
  788-  805 (34.13/21.09)	QQQQQQQQQQSHFLLKQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     132.49|      34|      34|    1238|    1271|       3
---------------------------------------------------------------------------
 1238- 1271 (62.20/36.81)	RSKLMEDCYP.ARILALCH.AVWLHSASGYLQLLPQ
 1274- 1303 (50.40/28.36)	RSTWIPHVRSeGQFLYVCH.LV.....APFLQRFYQ
 1625- 1643 (19.89/ 6.50)	.................CHrAEWIHQSTTPLASFFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     135.01|      32|      32|    1408|    1439|       4
---------------------------------------------------------------------------
 1407- 1427 (28.76/12.77)	...........L..............PIFGETAQHF.WL..AVTKLGDP
 1428- 1461 (46.97/25.80)	VMTFSLYFPALF..............PFFGTAAVDM.VIvgAFSEICNC
 1462- 1503 (39.03/20.12)	VLKWILLDDRPYwwvhtagvsgqlshPL....KQFQ.WT..CETGPGSP
 1508- 1537 (20.25/ 6.68)	MVSASVWFNLLY.........nlqsdLVLGDLSGCLcWL..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.75|      27|      34|    1834|    1860|       5
---------------------------------------------------------------------------
 1813- 1831 (18.07/ 8.46)	........VD...QIRALSVSQIKQL..RLLI
 1834- 1860 (43.03/31.80)	EMEKSDKLVE...NLEAVRFKALSQI..GNLV
 1868- 1897 (30.65/20.22)	ENEDDNEIVRtwgELE.VR.KKYSQVdlGIMV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.72|      16|      31|     593|     609|       6
---------------------------------------------------------------------------
  593-  609 (25.66/21.17)	CRMLtYADLEILGLKQF
  623-  638 (34.06/23.33)	CEMM.YICCEILNYRLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.19|      22|      30|     310|     332|       7
---------------------------------------------------------------------------
  187-  213 (25.75/10.54)	CDRKNnlL.PaYF..VI.TEII.KNLpeqrCF
  310-  331 (39.47/23.16)	PEKSR..I.P.YFEEVI.TEII.LEL....MF
  335-  363 (25.97/12.24)	CDHSQ..LnP.QAWRIIsTQIIyLTLqqsiCF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.31|      18|      18|    1013|    1030|       8
---------------------------------------------------------------------------
 1013- 1030 (31.17/20.35)	LQKLVESPAACLKFLDST
 1034- 1051 (33.13/22.18)	LGPLYRFHPYPVSFLYST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      30.72|      10|      18|     652|     662|      12
---------------------------------------------------------------------------
  652-  662 (13.55/10.34)	LQQTLaFAKFQ
  671-  680 (17.18/ 8.30)	LERTL.LLQFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.13|      17|      18|     422|     439|      15
---------------------------------------------------------------------------
  422-  439 (26.24/17.59)	IFTVSGSDSSCVlMLAPT
  443-  459 (30.89/16.62)	IHILKKSPSMEV.ELPPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.72|      15|      80|     286|     300|      17
---------------------------------------------------------------------------
  286-  300 (28.85/19.74)	RLLTHVFMHYTYRDA
  368-  382 (28.86/19.75)	KILHTKLTHYPYRYA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.66|      30|     230|    1112|    1142|      18
---------------------------------------------------------------------------
 1112- 1142 (50.03/35.86)	YYAALVRRLMDTFSePRQQWSRKSDLRFVEF
 1347- 1376 (49.63/30.69)	YVGDSVRQETDRII.PMLRTSLQQKLRYISF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06357 with Med23 domain of Kingdom Metazoa
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