<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06357

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMFYCITGFYSFIVMSLSLSDFETKVKNLFKEHAKSGIAYFFFRPYLMTSSEECEKKIIILTANELVEIFTSVPQNLQESAFSIVISHRVLSNSANKIVDFFVRDVTQRQILSIKCICEKLLTCAELNINSCGWNDTFAFFMENISLLDYKGVRDTLKRLLDIPIPVHLQVDQRKSVEAVEKLIKTICDRKNNLLPAYFVITEIIKNLPEQRCFSHWRMADCFTEIIESFRPLAQLNSVCGRTFMTPIPGHVGFYFNAFWKLEALSLRFPLKGLLPYSQDLLNPQMRLLTHVFMHYTYRDAIAVLLGTAKPEKSRIPYFEEVITEIILELMFTAECDHSQLNPQAWRIISTQIIYLTLQQSICFTRLVKILHTKLTHYPYRYARNQLMWCLFNFLSGGMQKYSVEEFAVILDLYRLLYTGRDIFTVSGSDSSCVLMLAPTCIWIHILKKSPSMEVELPPTVNTQRKFLQEALKNKTQFNTDNYMVAVLCNAYSSTSEIFQQDLLPILLENLDNARGHNSTQASGNFASNATTNSMSYPNGTVSEVKLRPLKLEFLDSVSVHVRMNIANSLIGTFGRFMQGKSAWPSPALVETYCRMLTYADLEILGLKQFTSHIVLTAARHQCCEMMYICCEILNYRLFNIPSTYRVHAIVTLQQTLAFAKFQTNASLYWMLERTLLLQFQWYPHYEIFQAPFARLLNSFVAVAADGTRQSIAENEELMRIIILTLARSTVISSNSDSCFIEGVYRELLNKLPSYSWPQSTLSVFPQQQQQPQPQQSNIVGSSQQQQQQQQQQQQQQQSHFLLKQQVDEEYIKHRTFGSELSLIDYFTNTSTSTVYLCLLWRLVYDTGELPAVSMKILEVLGPRKVLIHLKSLADFLVYETNSADVNRCVDVLNRLIFKYAVVPLERFMLTMLLRDYEGNDAFYALLIVMLLVQRSEELRSAVADCVAMLPSDYWHCQDWNDKYQAYQLKHAERTWSQVHTELSRASLTPNDCPLPVYFGTRCLQMLPVVDLLLQKLVESPAACLKFLDSTLSILGPLYRFHPYPVSFLYSTFRFYEKRLVEAPAIKQKLALAVHGACVPSRDDHWLLSAEFVSCVGSGPVTDRGPWVPDLNYYAALVRRLMDTFSEPRQQWSRKSDLRFVEFNNFQTHALYCICIELMSLSVSVVDVGNALITLVTHWHSLVDKNTVMYWVNAIGLIFSALPISYMEPFYQTILTTLCSDHMNSMNTDVSNKLDFEKRSKLMEDCYPARILALCHAVWLHSASGYLQLLPQALRSTWIPHVRSEGQFLYVCHLVAPFLQRFYQERTKFTMDITTDLYQMLYNVDCEVSSWKYEDLICDFFYHVKYMYVGDSVRQETDRIIPMLRTSLQQKLRYISFAQGEQSGTPFSEMINPIKLLGIQMVVWLQQLPIFGETAQHFWLAVTKLGDPVMTFSLYFPALFPFFGTAAVDMVIVGAFSEICNCVLKWILLDDRPYWWVHTAGVSGQLSHPLKQFQWTCETGPGSPSGHAMVSASVWFNLLYNLQSDLVLGDLSGCLCWLLYVVFLIAVSISRTYISAHFPDQVILGIVVGICIALVTRSLVGHRRRRWSNLIAFMIALLLIALSVHEAHRFLGVDTHRSIELAAKYCHRAEWIHQSTTPLASFFRDVGVLISIAMLLANKSMHTNNNNNNITSKPFSSKFAQALLGVGLNQLVALIPIGRLPIALFYAVLLPIVSICCFVVNMVLDLDNFRVEKGGNVQAVRISQQKRFQSVDLVDQVVETDQEWRRSRYLSDEWNRLKNLCSKEIGEKIKRKEPVHGDSTLPDSLTDKLQKVTVDQIRALSVSQIKQLRLLIDHEMEKSDKLVENLEAVRFKALSQIGNLVHNSVPVSENEDDNEIVRTWGELEVRKKYSQVDLGIMVDGYDSERGCSVAGSRGYFLKGPLVFLEQALIQLAMHMLYKKKYTPLYTPFFMRKEVMQEVAQLSDFDDQLYKVIGKSSEVKEDIAEEEKYLIATSEQPIAAYHRDEWISKESLPLRYIGFSTCFRQEVGSHGRDTSGIFRVHQFEKVEQFCITSPHDDASWEMLEEMILNAEMFYQTLNIPYRVVSIVSGELNNAAAKKYDLEAWFPGSGAFRELVSCSNCTDYQSRRLRIRYEFVHMLNGTMCATTRTICAILENFQEENGIVVPEALRPYMPDDYKDFIPFVKAAPKVDQQAAKRGNKSATEKSTHYVRSNSKYAQEFCRTLFVCSLSLNVAHQSGAIGCLGWFLEFCIILPRTFTACTILAVDRYGPVDRFLCLNLLLQSRTRFYKFAAVVNLRRCGCRQIFLLRTCKPAFSGQWFTLATAGNATVVDS
Length2329
PositionTail
OrganismTrichinella papuae
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.11
Grand average of hydropathy0.014
Instability index44.13
Isoelectric point7.17
Molecular weight267073.03
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-KW
serine-tRNA ligase activity	GO:0004828	IEA:UniProtKB-EC

GO - Biological Process
seryl-tRNA aminoacylation	GO:0006434	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06357
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.22|      26|      31|    2216|    2245|       1
---------------------------------------------------------------------------
 2216- 2243 (43.57/33.69)	EFC....RTLFVCSLsLNVaHQSGAIG...CLGWF
 2245- 2277 (39.65/27.25)	EFCiilpRTFTACTI.LAV.DRYGPVDrflCLNLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.54|      18|      20|     766|     783|       2
---------------------------------------------------------------------------
  766-  783 (34.41/21.33)	QQQQQPQPQQSNIVGSSQ
  788-  805 (34.13/21.09)	QQQQQQQQQQSHFLLKQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     132.49|      34|      34|    1238|    1271|       3
---------------------------------------------------------------------------
 1238- 1271 (62.20/36.81)	RSKLMEDCYP.ARILALCH.AVWLHSASGYLQLLPQ
 1274- 1303 (50.40/28.36)	RSTWIPHVRSeGQFLYVCH.LV.....APFLQRFYQ
 1625- 1643 (19.89/ 6.50)	.................CHrAEWIHQSTTPLASFFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     135.01|      32|      32|    1408|    1439|       4
---------------------------------------------------------------------------
 1407- 1427 (28.76/12.77)	...........L..............PIFGETAQHF.WL..AVTKLGDP
 1428- 1461 (46.97/25.80)	VMTFSLYFPALF..............PFFGTAAVDM.VIvgAFSEICNC
 1462- 1503 (39.03/20.12)	VLKWILLDDRPYwwvhtagvsgqlshPL....KQFQ.WT..CETGPGSP
 1508- 1537 (20.25/ 6.68)	MVSASVWFNLLY.........nlqsdLVLGDLSGCLcWL..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.75|      27|      34|    1834|    1860|       5
---------------------------------------------------------------------------
 1813- 1831 (18.07/ 8.46)	........VD...QIRALSVSQIKQL..RLLI
 1834- 1860 (43.03/31.80)	EMEKSDKLVE...NLEAVRFKALSQI..GNLV
 1868- 1897 (30.65/20.22)	ENEDDNEIVRtwgELE.VR.KKYSQVdlGIMV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.72|      16|      31|     593|     609|       6
---------------------------------------------------------------------------
  593-  609 (25.66/21.17)	CRMLtYADLEILGLKQF
  623-  638 (34.06/23.33)	CEMM.YICCEILNYRLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.19|      22|      30|     310|     332|       7
---------------------------------------------------------------------------
  187-  213 (25.75/10.54)	CDRKNnlL.PaYF..VI.TEII.KNLpeqrCF
  310-  331 (39.47/23.16)	PEKSR..I.P.YFEEVI.TEII.LEL....MF
  335-  363 (25.97/12.24)	CDHSQ..LnP.QAWRIIsTQIIyLTLqqsiCF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.31|      18|      18|    1013|    1030|       8
---------------------------------------------------------------------------
 1013- 1030 (31.17/20.35)	LQKLVESPAACLKFLDST
 1034- 1051 (33.13/22.18)	LGPLYRFHPYPVSFLYST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      30.72|      10|      18|     652|     662|      12
---------------------------------------------------------------------------
  652-  662 (13.55/10.34)	LQQTLaFAKFQ
  671-  680 (17.18/ 8.30)	LERTL.LLQFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.13|      17|      18|     422|     439|      15
---------------------------------------------------------------------------
  422-  439 (26.24/17.59)	IFTVSGSDSSCVlMLAPT
  443-  459 (30.89/16.62)	IHILKKSPSMEV.ELPPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.72|      15|      80|     286|     300|      17
---------------------------------------------------------------------------
  286-  300 (28.85/19.74)	RLLTHVFMHYTYRDA
  368-  382 (28.86/19.75)	KILHTKLTHYPYRYA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.66|      30|     230|    1112|    1142|      18
---------------------------------------------------------------------------
 1112- 1142 (50.03/35.86)	YYAALVRRLMDTFSePRQQWSRKSDLRFVEF
 1347- 1376 (49.63/30.69)	YVGDSVRQETDRII.PMLRTSLQQKLRYISF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06357 with Med23 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA