<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06356

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMFYCITGFYSFIVMSLSLSDFETKVKNLFKEHAKSGIAYFFFRPYLMTSSEECEKKIIILTANELVEIFTSVPQNLQESAFSIVISHRVLSNSANKIVDFFVRDVTQRQILSIKCICEKLLTCAELNINSCGWNDTFAFFMENISLLDYKGVRDTLKRLLDIPIPVHLQVDQRKSVEAVEKLIKTICDRKNNLLPAYFVITEIIKNLPEQRCFSHWRMADCFTEIIESFRPLAQLNSVCGRTFMTPIPGHVGFYFNAFWKLEALSLRFPLKGLLPYSQDLLNPQMRLLTHVFMHYTYRDAIAVLLGTAKPEKSRIPYFEEVITEIILELMFTAECDHSQLNPQAWRIISTQIIYLTLQQSICFTRLVKILHTKLTHYPYRYARNQLMWCLFNFLSGGMQKYSVEEFAVILDLYRLLYTGRDIFTVSGSDSSCVLMLAPTCIWIHILKKSPSMEVELPPTVNTQRKFLQEALKNKTQFNTDNYMVAFFCIKLDQKNLKFSDSSTSEIFQQDLLPILLENLDNARGHNSTQASGNFASNATTNSMSYPNGTVSEVKLRPLKLEFLDSVSVHVRMNIANSLIGTFGRFMQGKSAWPSPALVETYCRMLTYADLEILGLKQFTSHIVLTAARHQCCEMMYICCEILNYRLFNIPSTYRVHAIVTLQQTLAFAKFQTNASLYWMLERTLLLQFQWYPHYEIFQAPFARLLNSFVAVAADGTRQSIAENEELMRIIILTLARSTVISSNSDSCFIEGVYRELLNKLPSYSWPQSTLSVFPQVFCSHYTQQQQQQQQQQQQQQQQQQQQQQPQQQQQPQPQQSNIVGSSQQQQQQQQQQQQQQQSHFLLKQQVDEEYIKHRTFGSELSLIDYFTNTSTSTVYLCLLWRLVYDTGELPAVSMKILEVLGPRKVLIHLKSLADFLVYETNSADVNRCVDVLNRLIFKYAVVPLERFMLTMLLRDYEGNDAFYALLIVMLLVQRSEELRSAVADCVAMLPSDYWHCQDWNDKYQAYQLKHAERTWSQVHTELSRASLTPNDCPLPVYFGTRCLQMLPVVDLLLQKLVESPAACLKFLDSTLSILGPLYRFHPYPVSFLYSTFRFYEKRLVEAPAIKQKLALAVHGACVPSRDDHWLLSAEFVSCVGSGPVTDRGPWVPDLNYYAALVRRLMDTFSEPRQQWSRKSDLRFVEFNNFQTHALYCICIELMSLSVSVVDVGNALITLVTHWHSLVDKNTVMYWVNAIGLIFSALPISYMEPFYQTILTTLCSDHMNSMNTDVSNKLDFEKRSKLMEDCYPARILALCHAVWLHSASGYLQLLPQALRSTWIPHVRSEGQFLYVCHLVAPFLQRFYQERTKFTMDITTDLYQMLYNVDCEVSSWKYEDLICDFFYHVKYMYVGDSVRQETDRIIPMLRTSLQQKLRYISFAQGEQSGTPFSGLLILKLKSNLFYEFILLDRFYTCRRSWYSFGVAVFQKLWKIEFYSYFYAHRNDQSDKIVGNSDGCMASTIAHIWRNGAAFLARGDQTGRSGNDIFSLLSSFVSIFWHRGSGYGYCWCFQILLDDRPYWWVHTAGVSGQLSHPLKQFQWTCETGPGSPSGHAMVSASVWFNLLYNLQSDLVLGDLSGCLCWLLYVVFLIAVSISRTYIRICIALVTRSLVGHRRRRWSNLIAFMIALLLIALSVHEAHRFLGVDTHRSIELAAKYCHRAEWIHQSTTPLASFFRDVGVLISIAMLLANKSMHTNNNNNNITSKPFSSKFAQALLGVGLNQLVALIPIGRLPIALFYAVLLPIVSICCFVVNMVLDLDNFRVEKGGNVQAVRISQQKRFQSVDLVDQVVETDQEWRRSRYLSDEWNRLKNLCSKEIGEKIKRKEPVHGDSTLPDSLTDKLQKVTVDQIRALSVSQIKQLRLLIDHEMEKSDKLVENLEAVRFKALSQIGNLVHNSVPVSENEDDNEIVRTWGELEVRKKYSQVDLGIMVDGYDSERGCSVAGSRGYFLKGPLVFLEQALIQLAMHMLYKKKYTPLYTPFFMRKEVMQEVAQLSDFDDQLYKVIGKSSEVKEDIAEEEKYLIATSEQPIAAYHRDEWISKESLPLRYIGFSTCFRQEVGSHGRDTSGIFRVHQFEKVEQFCITSPHDDASWEMLEEMILNAEMFYQTLNIPYRVVSIVSGELNNAAAKKYDLEAWFPGSGAFRELVSCSNCTDYQSRRLRIRYEFVHMLNGTMCATTRTICAILENFQEENGIVVPEALRPYMPDDYKDFIPFVKAAPKVDQQAAKRGNKSATEKSTHYVRSNSKYAQEFCRTLFVCSLSLNVAHQSGAIGCLGWFLEFCIILPRTFTACTILAVDRYGPVDRFLCLNLLLQSRTRFYKFAAVVNLRRCGCRQIFLLRTCKPAFSGQWFTLATAGNATVVDS
Length2397
PositionTail
OrganismTrichinella papuae
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.12
Grand average of hydropathy-0.063
Instability index46.41
Isoelectric point7.97
Molecular weight275952.17
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-KW
serine-tRNA ligase activity	GO:0004828	IEA:UniProtKB-EC

GO - Biological Process
seryl-tRNA aminoacylation	GO:0006434	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06356
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.57|      34|      34|     774|     807|       1
---------------------------------------------------------------------------
  766-  804 (64.03/38.50)	PQStlsvfPQVFCSHYTQQQQQQQQQQQQQQQQQQQ....QQQ
  805-  845 (56.54/33.15)	PQQ..qqqPQPQQSNIVGSSQQQQQQQQQQQQQQQShfllKQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.96|      29|     119|     177|     207|       2
---------------------------------------------------------------------------
  177-  207 (42.76/38.32)	EAVEKLIKTICDRKNNlLPaYF..VITEIIKNL
  299-  329 (45.20/30.34)	DAIAVLLGTAKPEKSR.IP.YFeeVITEIILEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.66|      32|      67|    1368|    1399|       3
---------------------------------------------------------------------------
 1368- 1399 (60.65/36.10)	SSWKYEDLICDFFYHVK..YMYVGDSVRQETDRI
 1436- 1469 (54.01/31.29)	SNLFYEFILLDRFYTCRrsWYSFGVAVFQKLWKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.21|      17|      17|    1553|    1569|       4
---------------------------------------------------------------------------
 1553- 1569 (33.34/19.62)	RPYWWVHTAGVSGQLSH
 1572- 1588 (33.88/20.07)	KQFQWTCETGPGSPSGH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.41|      24|     657|    1160|    1186|       5
---------------------------------------------------------------------------
 1160- 1186 (37.34/35.83)	LMDTFSEPRQQWsRKSdlRFV..EFNNFQ
 1820- 1845 (40.08/25.80)	LVDQVVETDQEW.RRS..RYLsdEWNRLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.74|      40|     538|    1725|    1796|       6
---------------------------------------------------------------------------
 1674- 1723 (59.35/56.06)	AHRFLGVDTHRSIELaakychraewIHQSTTPLASFFRDVGVLISIAMLL
 1747- 1786 (67.39/40.54)	AQALLGVGLNQLVAL..........IPIGRLPIALFYAVLLPIVSICCFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     179.97|      59|     171|     878|     943|       9
---------------------------------------------------------------------------
  878-  943 (90.67/74.60)	LLWRLVydtgELPAVSMKILE....VLGPrkvLIHLKSLADFLVYETNSADVNRCVD...VLNRLIFKY..AVVP
 1052- 1119 (89.30/56.12)	LLQKLV....ESPAACLKFLDstlsILGP...LYRFHPYPVSFLYSTFRFYEKRLVEapaIKQKLALAVhgACVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.08|      16|     120|    1472|    1494|      13
---------------------------------------------------------------------------
 1472- 1489 (22.54/29.70)	YSYFYAhRNDQSDKiVGN
 1505- 1520 (28.54/10.57)	GAAFLA.RGDQTGR.SGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.12|      40|     941|     375|     417|      14
---------------------------------------------------------------------------
  375-  417 (71.16/49.83)	THYPYRYARNQLMW.C..LFNFLSGGMQ...KYSVEefaVILDLYRLLY
 1316- 1361 (62.96/36.51)	TWIPHVRSEGQFLYvChlVAPFLQRFYQertKFTMD...ITTDLYQMLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.28|      15|      17|     947|     961|      15
---------------------------------------------------------------------------
  947-  961 (27.35/21.19)	FMLTMLL..RDYEGNDA
  965-  981 (18.93/11.87)	LLIVMLLvqRSEELRSA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06356 with Med23 domain of Kingdom Metazoa
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