<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06351

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMASCTVAWEKKPLKRPRLGQPDDELTAEKVRQGYIYKPPLLNEYESLRSQRFDENLEDYFIKLTQSYNAIVNKKAEINALQDSYKKKSGFKEPSIWHLAAKPKGQDTWFKDLSGNKPLSALGKRFPFLNKKDEILYTLAEFNVPMVRVVWFLKMTNAHIAQQQECGKMKKKHMSDPFADWTHLVMKYLRDLCSKLGEFFSLSLEVPMNSEFECHYRHWQYTTKLTRHLFEEGLLDKEMLLNGLLDIFAEKIYASSFGILKMIVPVLLQFIDGFVMSVLLSRRLVYLACKVLSAMKIDNLQNDSENMKEGTLDYLNCPFHRTVLLGLSNVVHSVLIDCPTALIWNEMECEDTGENGKAYLCGSPLDLLYCSPVDLPLFVDPSTEFVKKELERLTEMVTERSRAVESHWSYNKCQHSGLSTIIQHFLSILDCLDKFKFEYVNETNNIDTLYKTIFQSEKKEIRVDMDSIAVQFLCHWAVSPHRYGSYRAAVVTRLFERHLQELSKKMPQVRYPFQKSLFNYLHNQAPNLGEMCSSSEIKPFTNLILLFSRLIESDIFSHDQYVSTLVSSGDLIPNGANVFYPLQNQCSSSASAVENVSNTQPAVLMSNNFFSEHFKPIENVDFNYFKDSDESKLDFDRIIDFADKKAISSDADSCSSKRVPKLSKHYFNVLHFPVPQLTKELNKLWSKKTSAELTTTGLIRVRKIIDSESLCSLSRKIQNLVFYDQFAVMDCCCDAGIVQFNSFINGQSNCLPTLENFDFLLGLLEESSNFISLVEFMEAVICLLPKLEAQIVERNFQGANSLTLQYAVCMVGYMRKHHCYFIQLESVMCNIWRSLLLYVKSKTVVNSFSAERCVWVYLHDLYQCCSYIRSLHADLYLNSRDCIQRCLCVETKPSSCNDLRGLLADVSQEIMLDVLFQESDLVIEPNLIQRLVENANLCYAFAIVAVKALCGLSGDTERLFNLVLFCADVTALCPNLNADWLAVFKILCCPFNSSQDQTSCDSLLNIDVSDHQCYQPLTVLAITLISRMCIRLEDFILHVAMPSLLPLWKHAGSAKVEKGPEASAKLTLHLLGKILLFFDYQGPKNALPAKTKGELSLICSSVDGMVPDAILTLLIAILMLDDSKVQELKSKENFDTKRSAKQFVEEDTNTAGNSDIGSTAIQLLELICRQEWTKRKFLHSTDLFDPKRLLNPLVNQTQAQRLLRMITRSDSEILLKKFDSCTTKKELISKVLDSLTIMNLWVSQMDLQLLLKQVANSQSESLHLVDTIAKSCMEVFQPQATLTFGEPSDDKDENAYLNALSFDEIAPYWLVAPLISRLPSFVQGRVLKAAVSILENCQARRDRNLFAQSSSLLAHQPFLSLVLICLRGQDDQREGLLSSLLKQIQEFVMRVKEDPYILCDREIVSEMLDALQLRLSLIGGMFDTVCRNANLENWSLVMVQLLLYGIVTEEKNQALFYTCVDILCVLLLSCLLPDSAGFSFSGQERTNEDCKRIYNNVIKKLKKEIGDRQMPSLRCVHQLLPIPRQMVDVIVCDEYGLQPQKGSRGGFSSSEVTQRKGLQIIGKEKLNPWEIIEGYNRENIGLKWSWFQGIRLDYQPETLFEQMMRMLPHDHHHAFNRPPMPGEPRSDPFLETLQVHYVPCTNETSDSDKLTTERLKSNGSVAISGGTLVSEFSDQVQSPRTTKARPRKSTRGRKSSSRVTVSSNVALSSVPPMVQNRQLSIGQPTITAHYGYFPQQVAMTGGPSGAVPPYGQGQMWSIGNVQSASTAVPPTQYQSRNFTGAQMAPMQSSSGKQAISAMIRGRRPSGSGGQQMMSAAHIQPAPLAAGQPYHQQQLHSIGQVDPMVAPMHQVQMQMDARQQLMQESMMEQQMRTPGPRSMATQQHCLAQVNSAASQPVMHGNYSNYPGQHGAARMQITSGRNQYVAQPAQPPFNCSPNYNAQFYQAQNAGQMRMPQTDVIAQSNVRYTQQPNYQMQSQQTLRAPAGYVAQQANPMYAAPNTPQYQAAQQQNVSMYPVSRMSQYSSNVPGQEMNASQQQINYYPPQY
Length2043
PositionKinase
OrganismTrichinella papuae
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.09
Grand average of hydropathy-0.241
Instability index47.25
Isoelectric point6.78
Molecular weight231384.28
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06351
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     239.53|      76|      90|    1375|    1455|       1
---------------------------------------------------------------------------
 1375- 1455 (115.65/109.49)	LLSSLLKQIQEFVMRVKEDPYILCDReIVSEMLDALQlrlSLIGG..MFDTVCRNaNLENWSLVMVQLLL...YGIVTEEKNQALF
 1466- 1546 (123.88/97.54)	LLSCLLPDSAGFSFSGQERTNEDCKR.IYNNVIKKLK...KEIGDrqMPSLRCVH.QLLPIPRQMVDVIVcdeYGLQPQKGSRGGF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.08|      13|      90|     325|     337|       2
---------------------------------------------------------------------------
  325-  337 (24.01/16.39)	GLSNVVHSVL..IDC
  416-  430 (20.07/12.31)	GLSTIIQHFLsiLDC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     110.27|      22|      23|    1855|    1876|       3
---------------------------------------------------------------------------
 1718- 1740 (30.04/13.28)	LSIGQPTI.TAHYGY..FPQQvaM........TG
 1814- 1843 (29.11/12.64)	AAHIQPAPLAAGQPY..HQQQ..LhsigqvdpMV
 1844- 1861 (23.76/ 8.96)	APMHQVQMQ......mdARQQ..L........MQ
 1862- 1886 (27.36/11.44)	ESMMEQQMRTPGPRS.mATQQhcL........AQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     117.50|      15|      91|    1902|    1916|       4
---------------------------------------------------------------------------
 1902- 1916 (27.12/12.72)	NYPGQHGAARM..QITS
 1920- 1934 (24.53/10.79)	QYVAQPAQPPF..NCSP
 1935- 1951 (20.56/ 7.85)	NYNAQFYQAQNagQMRM
 1983- 1996 (22.21/ 9.08)	GYVAQQ.ANPM..YAAP
 1997- 2010 (23.08/ 9.72)	NTP.QYQAAQQ..QNVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     180.70|      41|      96|    1656|    1696|       5
---------------------------------------------------------------------------
 1656- 1696 (65.84/47.55)	SNGSVAISGGTLVSEFSDQVQSPR........................TTKAR..PRKSTRGRKSSS
 1698- 1753 (31.72/18.00)	....VTVSSNVALSSVPPMVQNRQlsigqptitahygyfpqqvamtggPSGAV..P.PYGQGQ....
 1756- 1795 (61.75/44.02)	SIGNVQ.SASTAVP..PTQYQSRN........................FTGAQmaPMQSSSGKQAIS
 1797- 1813 (21.39/ 9.04)	..................MIRGRR........................PSG.......SG.GQQMMS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     156.33|      42|      48|    1172|    1213|       7
---------------------------------------------------------------------------
 1127- 1168 (26.13/10.13)	.....LKSKENFDTKRSAKQFVEEdtntagnsdigSTAIQLLELICR......
 1172- 1213 (70.38/38.76)	TKRKFLHSTDLFDPKRLLNPLVNQ...........TQAQRLLRMITRSDSEIL
 1222- 1261 (59.82/31.93)	TKKELI..SKVLDSLTIMNLWVSQ...........MDLQLLLKQVANSQSESL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     432.16|     114|     667|     169|     306|       9
---------------------------------------------------------------------------
  169-  285 (189.51/129.95)	KKKHMSDP..FADWTHLVMKYLRDLCSKLGEFFSLSLEVPMNSEFECH......YRHWQYTTKLTRHLFEEGLL...DKEMLLNgLLDIFAEK..IYASSFGILKMIvpVLLQFIDGFVMSVLLSR.....RLVY
  839-  938 (144.81/86.61)	KSKTVVNS..FSA.ERCVWVYLHDLYQCCSYIRSLHADLYLNSR.DCI......QRCLCVETKPSSCNDLRGLLadvSQEIMLD.........................VLFQESDLVIEPNLIQRlvenaNLCY
 1006- 1097 (97.84/75.66)	...DVSDHqcYQPLTVLAITLISRMCIRLEDFI.LHVAMPSLLPLWKHagsakvEKGPEASAKLTLH.....LL...GKILL...FFDYQGPKnaLPAKTKGELSLI............................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.10|      35|      49|     744|     783|      10
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  744-  783 (42.22/44.82)	NGqSNCLpTLENFDFLLGLLEESSNFisLVEfMEAVIC.....LL
  796-  835 (59.89/37.03)	QG.ANSL.TLQYAVCMVGYMRKHHCY..FIQ.LESVMCniwrsLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.24|      42|     936|     338|     386|      12
---------------------------------------------------------------------------
  338-  386 (62.07/67.36)	PTA.LIWNEmECEDTGENgkAYLCGSPLDLLycSPVDL..PLFVD.PSteFVK
 1277- 1322 (66.17/43.70)	PQAtLTFGE.PSDDKDEN..AYLNALSFDEI..APYWLvaPLISRlPS..FVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.30|      31|      42|    1567|    1597|      14
---------------------------------------------------------------------------
 1567- 1597 (60.17/36.10)	PWEIIEGYNRENI.GLKWS..WFQGIRLDYQPET
 1607- 1640 (52.13/30.30)	PHDHHHAFNRPPMpGEPRSdpFLETLQVHYVPCT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06351 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GQMRMPQTDVIAQSNVRYTQQPNYQMQSQQTLRAP
2) GTLVSEFSDQVQSPRTTKARPRKSTRGRKSSSRVTVSSNVALSSVPPMVQNRQLSI
3) IGNVQSASTAVPPTQYQSRNFTGAQMAPMQSSSGKQAISAMIRGRRPSGSGGQQMMSAAHIQPAPLAAGQPYHQQQLHSIGQVDPMVAPMHQVQMQMDARQQLMQESMMEQQMRTPGPRSMATQQHCLAQVNSAA
4) PVMHGNYSNYPGQHGAARMQITSGRNQYVAQPAQPP
5) RMLPHDHHHAFNRPPMPGEPRSDPFLETLQ
1947
1665
1757
1894
1604
1981
1720
1891
1929
1633










Molecular Recognition Features






MoRF SequenceStartStop




1) ISAMI
2) YYPPQY
1794
2038
1798
2043