<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06350

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMASCTVAWEKKPLKRPRLGQPDDELTAEKVRQGYIYKPPLLNEYESLRSQRFDENLEDYFIKLTQSYNAIVNKKAEINALQDSYKKKSGFKEPSIWHLAAKPKGQDTWFKDLSGNKPLSALGKRFPFLNKKDEILYTLAEFNVPMVRVVWFLKMTNAHIAQQQECGKMKKKHMSDPFADWTHLVMKYLRDLCSKLGEFFSLSLEVPMNSEFECHYRHWQYTTKLTRHLFEEGLLDKEMLLNGLLDIFAEKIYASSFGILKMIVPVLLQFIDGFVMSVLLSRRLVYLACKVLSAMKIDNLQNDSENMKEGTLDYLNCPFHRTVLLGLSNVVHSVLIDCPTALIWNEMECEDTGENGKAYLCGSPLDLLYCSPVDLPLFVDPSTEFVKKELERLTEMVTERSRAVESHWSYNKCQHSGLSTIIQHFLSILDCLDKFKFEYVNETNNIDTLYKTIFQSEKKEIRVDMDSIAVQFLCHWAVSPHRYGSYRAAVVTRLFERHLQELSKKMPQVRYPFQKSLFNYLHNQAPNLGEMCSSSEIKPFTNLILLFSRLIESDIFSHDQYVSTLVSSGDLIPNGANVFYPLQNQCSSSASAVENVSNTQPAVLMSNNFFSEHFKPIENVDFNYFKDSDESKLDFDRIIDFADKKAISSDADSCSSKRVPKLSKHYFNVLHFPVPQDDQYRHECNQRQLLLFGSNFDQYSRKHILKKLTKELNKLWSKKTSAELTTTGLIRVRKIIDSESLCSLSRKIQNLVFYDQFAVMDCCCDAGIVQFNSFINGQSNCLPTLENFDFLLGLLEESSNFISLVEFMEAVICLLPKLEAQIVERNFQGANSLTLQYAVCMVGYMRKHHCYFIQLESVMCNIWRSLLLYVKSKTVVNSFSAERCVWVYLHDLYQCCSYIRSLHADLYLNSRDCIQRCLCVETKPSSCNDLRGLLADVSQEIMLDVLFQESDLVIEPNLIQRLVENANLCYAFAIVAVKALCGLSGDTERLFNLVLFCADVTALCPNLNADWLAVFKILCCPFNSSQDQTSCDSLLNIDVSDHQCYQPLTVLAITLISRMCIRLEDFILHVAMPSLLPLWKHAGSAKVEKGPEASAKLTLHLLGKILLFFDYQGPKNALPAKTKGELSLICSSVDGMVPDAILTLLIAILMLDDSKVQELKSKENFDTKRSAKQFVEEDTNTAGNSDIGSTAIQLLELICRQEWTKRKFLHSTDLFDPKRLLNPLVNQTQAQRLLRMITRSDSEILLKKFDSCTTKKELISKVLDSLTIMNLWVSQMDLQLLLKQVANSQSESLHLVDTIAKSCMEVFQPQATLTFGEPSDDKDENAYLNALSFDEIAPYWLVAPLISRLPSFVQGRVLKAAVSILENCQARRDRNLFAQSSSLLAHQPFLSLVLICLRGQDDQREGLLSSLLKQIQEFVMRVKEDPYILCDREIVSEMLDALQLRLSLIGGMFDTVCRNANLENWSLVMVQLLLYGIVTEEKNQALFYTCVDILCVLLLSCLLPDSAGFSFSGQERTNEDCKRIYNNVIKKLKKEIGDRQMPSLRCVHQLLPIPRQMVDVIVCDEYGLQPQKGSRGGFSSSEVTQRKGLQIIGKEKLNPWEIIEGYNRENIGLKWSWFQGIRLDYQPETLFEQMMRMLPHDHHHAFNRPPMPGEPRSDPFLETLQVHYVPCTNETSDSDKLTTERLKSNGSVAISGGTLVSEFSDQVQSPRTTKARPRKSTRGRKSSSRVTVSSNVALSSVPPMVQNRQLSIGQPTITAHYGYFPQQVAMTGGPSGAVPPYGQGQMWSIGNVQSASTAVPPTQYQSRNFTGAQMAPMQSSSGKQAISAMIRGRRPSGSGGQQMMSAAHIQPAPLAAGQPYHQQQLHSIGQVDPMVAPMHQVQMQMDARQQLMQESMMEQQMRTPGPRSMATQQHCLAQVNSAASQPVMHGNYSNYPGQHGAARMQITSGRNQYVAQPAQPPFNCSPNYNAQFYQAQNAGQMRMPQTDVIAQSNVRYTQQPNYQMQSQQTLRAPAGYVAQQANPMYAAPNTPQYQAAQQQNVSMYPVSRMSQYSSNVPGQEMNASQQQINYYPPQY
Length2074
PositionKinase
OrganismTrichinella papuae
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.09
Grand average of hydropathy-0.258
Instability index47.30
Isoelectric point6.94
Molecular weight235247.56
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06350
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     236.52|      54|      60|    1741|    1800|       1
---------------------------------------------------------------------------
 1648- 1700 (49.35/33.12)	......................................PPMPGEP..........RSDPFL..ETLQVHY......VPCTNE..TSdsdkltterlksnGSVAISG.GTLVS
 1703- 1787 (83.87/80.97)	SDQVQSPRTTKARprkstrgrksssrvtvssnvalssvPPMVQNR..........QLSIGQ..PTITAHYgyfpqqVAMTGG..PS.............GAVPPYGQGQMWS
 1788- 1844 (64.34/46.32)	IGNVQSASTAVPP..........................TQYQSRnftgaqmapmQSSSGK..QAIS..........AMIRGrrPS.............GS....GGQQMMS
 1845- 1882 (38.96/23.98)	AAHIQ.......P...................aplaagQPYHQQQ..........LHSIGQvdPM....................................VAPMHQVQM..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     130.77|      21|      40|    1936|    1956|       2
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 1912- 1929 (22.90/10.91)	.QH.CLA..QVNSAAS.QPVMHG
 1936- 1956 (37.15/23.11)	GQH.GAARMQITSGRN.QYVAQP
 1978- 1999 (26.78/14.23)	GQM.RMPQTDVIAQSNvRYTQQP
 2000- 2018 (23.16/11.13)	NYQ.MQSQ.QTLRAPA.GYVAQ.
 2057- 2074 (20.77/ 9.09)	GQEmNASQQQINYYPP.QY....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     156.33|      42|      49|    1203|    1244|       3
---------------------------------------------------------------------------
 1158- 1199 (26.13/14.54)	.....LKSKENFDTKRSAKQFVEEdtntagnsdigSTAIQLLELICR......
 1203- 1244 (70.38/55.09)	TKRKFLHSTDLFDPKRLLNPLVNQ...........TQAQRLLRMITRSDSEIL
 1253- 1292 (59.82/45.41)	TKKELI..SKVLDSLTIMNLWVSQ...........MDLQLLLKQVANSQSESL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     278.02|      87|      88|     603|     689|       4
---------------------------------------------------------------------------
  544-  608 (81.50/42.23)	.........................LLFSRLIEsdiFSHDQYVSTLVS..S.GDLIPNGANVFYPLQNQCSSSASAVENVSNTQPAVLMSNNF
  609-  695 (149.06/83.29)	FS.EHFKPIENVDFNYFKDSDES.KLDFDRIID...FADKKAISSDADSCS.SKRVPKLSKHYFNVLHFPVPQDDQYRHECNQRQLLLFGSNF
  698-  750 (47.45/21.54)	YSrKHILKKLTKELNKLWSKKTSaELTTTGLIR...V..RKIIDSES.LCSlSRKIQNL..................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     162.60|      39|      49|     929|     971|       5
---------------------------------------------------------------------------
  898-  921 (43.34/23.61)	IRSLHAD.........LYLNSR.....DCIQR.....C.......LCVET
  929-  971 (59.13/46.71)	LRGLLADVSQEIMLdVLFQESDLVIEPNLIQRlveNAN.......LCYAF
  979- 1021 (60.13/35.71)	LCGLSGDTERLFNL.VLFCADVTALCPNL......NADwlavfkiLCCPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.93|      18|      64|    1957|    1976|       6
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 1957- 1976 (31.99/26.15)	AQPPFNC..SPNYNAQfyQAQN
 2020- 2039 (29.94/16.41)	ANPMYAApnTPQYQAA..QQQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     239.53|      76|      88|    1406|    1486|       7
---------------------------------------------------------------------------
 1406- 1486 (115.65/90.31)	LLSSLLKQIQEFVMRVKEDPYILCDReIVSEMLDALQlrlSLIGG..MFDTVCRNaNLENWSLVMVQLLL...YGIVTEEKNQALF
 1497- 1577 (123.88/80.44)	LLSCLLPDSAGFSFSGQERTNEDCKR.IYNNVIKKLK...KEIGDrqMPSLRCVH.QLLPIPRQMVDVIVcdeYGLQPQKGSRGGF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.73|      44|      49|     779|     826|       9
---------------------------------------------------------------------------
  774-  825 (53.68/43.10)	IngqsNCLpTLENFDFLLGLLEESSNFisLVEfMEAVIC.....LLPKLEAQIVERN
  826-  877 (66.05/36.77)	F.qgaNSL.TLQYAVCMVGYMRKHHCY..FIQ.LESVMCniwrsLLLYVKSKTVVNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.57|      36|      43|    1070|    1109|      11
---------------------------------------------------------------------------
 1070- 1109 (47.78/45.08)	AMPSLLPLwKHAGS.....AKVEkGPEASAKLTlhLLGKILLFFD
 1112- 1152 (55.78/33.96)	GPKNALPA.KTKGElslicSSVD.GMVPDAILT..LLIAILMLDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.98|      50|     324|      83|     134|      12
---------------------------------------------------------------------------
   83-  134 (80.58/62.72)	SYKK..KSGFKEPsIWHLAAKPKGQDTW.FKDLSGNKPLSALGKRFpFLNKKDEI
  408-  460 (77.40/50.44)	SYNKcqHSGLSTI.IQHFLSILDCLDKFkFEYVNETNNIDTLYKTI.FQSEKKEI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06350 with Med12 domain of Kingdom Metazoa
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