<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06347

Description Mediator of RNA polymerase II transcription subunit 14 (Fragment)
SequenceLFWMTSFNASLIKCTITKMSGDEESMDFEEKLAAFPLPSIPANQGPPFMAFGVLLDFAVQKTYQDFVILTDLLPKKSDLDRKISIAQFAHSARQLFVRLYAILKWARCGAKVDLCTGIVCFLDQQASMFVDTADRLYQMNCDVLQNARLPAFQIPTAVDVLTLGTYPRLPSVIKREFIRTADISQEEEECVLHRLNYVIERRLLPSLLTLPEGMRNFTVNNGMATFHVAGEFEAKLTLLGQLPRTPWTLLKLRILVSDPRVTDGSDVLSSLQLSYLHHLIQSRLNVSKEPIVELYRVIHCFCLSAQLDILCCQAYRLIGDFMSENLSVEEYISSEKLVISYWKERNQGGIASFKIIFWINQDEPFAPLQVSHIPKSDLKLPTMDTESGQLALDNLLTETVLIRVKHRLQQLCDFLLTIKGLTCTFISDMPALSVTFLPGSNSTEILDLSMNLFTGKFVCRLPAFDEDISLIAELTEKLDDNHWNCLEDLLHQIRVRIFMNRVDHAMRFFTLKVCETLPAFLKTTCEQWPIDRRLIIKFHRFENYFIVLTFNDHPDDSTKVNLDFWLVCNETVSNAIRSADDDDRSKKNVNLLHFDLRKFVSESKVFNQLCLLSLKIQKKQCVIPELMAAFSMCENAMPFFLLMEEMERTSARYAYHQLFDGTVVLRVLGIDQTCDHNFEKILGLPKGLAISLSYDRHRLVWSMELNTVGSPLGDSSSFGKAVHRKITILTCTVGNESARKCLDDVSSGVRCFSALYEPVKALARAYKGCLHRLTPLSMLSSYKLTLVYGPKLRYVCHLQWKPSERMYILSFGVDNSVLNEEYVYFNPHSILCGHLQHWFNSVRDISALSHLLQASSAALQALTTLPDTIFRVGSEHTSNQMLYLNRMFSILPTGPDTVRLLCKDHLCLEMRFTFSGSIFMRDCGSAFGLPQMKSVKYVPITGFKTFLNLHISEMKAAIEAERKVSTAVNDSFMEVSDVDFSGNTFQANSNSGTGSSMVLENSMRISTQNRLSGNSLANDDGHAEPSSRSPPEDWTPCVVPIEIQQNAFIRICSPSGTHPHPEWSHLQKFILSVEVLEKMKEQANNFTVIRPGQLSLKCNQSEMKFFLNESNLSSVMFKFFRDENDACTEGDVQFLEKYFLEQISSTYNATAMYAFVRMLTVCQTIRRDLLSSFLSIMNIQQHVYVESSTAYWIPEMCFLIPSPQLVPTTYLSRATLMPGGSAIVANVVQKKMLFWIKFVRVADPSHCVAFPFLYDGENNSLQVFRGTNQQTAQQSNNTVYPIETCLLRQQQTHSAFSECVVWPCIRDVMHINELIPGRS
Length1319
PositionTail
OrganismTrichinella papuae
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.10
Grand average of hydropathy-0.021
Instability index40.70
Isoelectric point6.28
Molecular weight149995.62
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06347
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     199.92|      62|     354|     113|     174|       1
---------------------------------------------------------------------------
  113-  174 (111.76/68.99)	DLCTG.IVCFL...DQQASMFVDTADRL..YQMNC..DVLQNARLPAF..QIPTAVDVLTLGTYPRLPSVIK
  451-  522 (88.17/52.89)	NLFTGkFVCRLpafDEDISLIAELTEKLddNHWNCleDLLHQIRVRIFmnRVDHAMRFFTLKVCETLPAFLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     445.74|     144|     455|     551|     718|       2
---------------------------------------------------------------------------
  551-  718 (216.13/200.14)	ND..HPDDSTKVNLDFWLVCN...ETVSNAIRSADDDDRSKKNVNLLHfdLRKFVSESKVFNQlcllsLKIQKKQC.VIPELMAAFSMCENAMPFFLlmEEMERTSARYAYHQlfDGtvvlrvlgiDQTC...DHNF.EKILgLPKglaISLSYDRHRLVWSMELNTVGSPLGDS..SSF
 1018- 1173 (229.61/152.47)	NDdgHAEPSSRSPPEDWTPCVvpiEIQQNAFIRICSPSGTHPHPEWSH..LQKFILSVEVLEK.....MKEQANNFtVIRPGQLSLKCNQSEMKFFL..NESNLSSVMFKFFR..DE.........NDACtegDVQFlEKYF.LEQ...ISSTYNATAMYAFVRMLTVCQTIRRDllSSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.99|      36|     455|     342|     450|       3
---------------------------------------------------------------------------
  348-  390 (51.17/113.82)	GG......IASFKIIFWINqdepFapLQVSHiPKSDLKLPTM.DTESGQL
 1219- 1261 (56.82/ 9.75)	GGsaivanVVQKKMLFWIK....F..VRVAD.PSHCVAFPFLyDGENNSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.49|      31|     455|     823|     856|       5
---------------------------------------------------------------------------
  787-  817 (59.84/35.63)	VYGPKLRYVC.HLQ.WKPSER.MYILSFGVDNSV
  823-  856 (44.65/38.99)	VYFNPHSILCgHLQhWFNSVRdISALSHLLQASS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.08|      25|      28|     862|     889|       6
---------------------------------------------------------------------------
  862-  889 (40.47/34.88)	LTTLPDTIFRVGSEHTSNQMLYlnrMFS
  891-  915 (47.61/32.03)	LPTGPDTVRLLCKDHLCLEMRF...TFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.44|      21|      28|     965|     985|       7
---------------------------------------------------------------------------
  965-  985 (36.55/20.91)	STAVNDSFMEVSDVD.FSGNTF
  995- 1016 (30.89/16.67)	SSMVLENSMRISTQNrLSGNSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06347 with Med14 domain of Kingdom Metazoa
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