<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06346

Description Mediator of RNA polymerase II transcription subunit 14 (Fragment)
SequenceLFWMTSFNASLIKCTITKMSGDEESMDFEEKLAAFPLPSIPANQGPPFMAFGVLLDFAVQKTYQDFVILTDLLPKKSDLDRKISIAQFAHSARQLFVRLYAILKWARCGAKVDLCTGIVCFLDQQASMFVDTADRLYQMNCDVLQNARLPAFQIPTAVDVLTLGTYPRLPSVIKREFIRTADISQEEEECVLHRLNYVIERRLLPSLLTLPEGMRNFTVNNGMATFHVAGEFEAKLTLLGQLPRTPWTLLKLRILVSDPRVTDGSDVLSSLQLSYLHHLIQSRLNVSKEPIVELYRVIHCFCLSAQLDILCCQAYRLIGDFMSENLSVEEYISSEKLVISYWKERNQGGIASFKIIFWINQDEPFAPLQVSHIPKSDLKLPTMDTESGQLALDNLLTETVLIRVKHRLQQLCDFLLTIKGLTCTFISDMPALSVTFLPGSNSTEILDLSMNLFTGKFVCRLPAFDEDISLIAELTEKLDDNHWNCLEDLLHQIRVRIFMNRVDHAMRFFTLKVCETLPAFLKTTCEQWPIDRRLIIKFHRFENYFIVLTFNDHPDDSTKVNLDFWLVCNETVSNAIRSADDDDRSKKNVNLLHFDLRKFVSESKVKKQCVIPELMAAFSMCENAMPFFLLMEEMERTSARYAYHQLFDGTVVLRVLGIDQTCDHNFEKILGLPKGLAISLSYDRHRLVWSMELNTVGSPLGDSSSFGKAVHRKITILTCTVGNESARKCLDDVSSGVRCFSALYEPVKALARAYKGCLHRLTPLSMLSSYKLTLVYGPKLRYVCHLQWKPSERMYILSFGVDNSVLNEEYVYFNPHSILCGHLQHWFNSVRDISALSHLLQASSAALQALTTLPDTIFRVGSEHTSNQMLYLNRMFSILPTGPDTVRLLCKDHLCLEMRFTFSGSIFMRDCGSAFGLPQMKSVKYVPITGFKTFLNLHISEMKAAIEAERKVSTAVNDSFMEVSDVDFSGNTFQANSNSGTGSSMVLENSMRISTQNRLSGNSLANDDGHAEPSSRSPPEDWTPCVVPIEIQQNAFIRICSPSGTHPHPEWSHLQKFILSVEVLEKMKEQANNFTVIRPGQLSLKCNQSEMKFFLNESNLSSVMFKFFRDENDACTEGDVQFLEKYFLEQISSTYNATAMYAFVRMLTVCQTIRRDLLSSFLSIMNIQQHVYVESSTAYWIPEMCFLIPSPQLVPTTYLSRATLMPGGSAIVANVVQKKMLFWIKFVRVADPSHCVAFPFLYDGENNSLQVFRGTNQQTAQQSNNTVYPIETCLLRQQQTHSAFSECVVWPCIRDVMHINELIPGRS
Length1307
PositionTail
OrganismTrichinella papuae
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.10
Grand average of hydropathy-0.028
Instability index41.00
Isoelectric point6.23
Molecular weight148593.90
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06346
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.08|      25|      28|     850|     877|       1
---------------------------------------------------------------------------
  850-  877 (40.47/35.35)	LTTLPDTIFRVGSEHTSNQMLYlnrMFS
  879-  903 (47.61/32.48)	LPTGPDTVRLLCKDHLCLEMRF...TFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.06|      25|     354|     134|     174|       3
---------------------------------------------------------------------------
  146-  170 (45.12/55.16)	NARLPAFQIPTAVDV.LT.LGTYPRLP
  220-  246 (36.94/10.79)	NNGMATFHVAGEFEAkLTlLGQLPRTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.32|      36|     862|     348|     390|       5
---------------------------------------------------------------------------
  348-  390 (51.83/45.74)	GG...IAS...FKIIFWINqdepFapLQVSHiPKSDLKLPTM.DTESGQL
 1207- 1249 (53.49/28.16)	GGsaiVANvvqKKMLFWIK....F..VRVAD.PSHCVAFPFLyDGENNSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.47|      29|      30|     956|     984|       6
---------------------------------------------------------------------------
  956-  984 (49.82/41.10)	VNDSFMEVSDVD.FSGNTFQANSNSGTGSS
  986- 1015 (44.65/35.87)	VLENSMRISTQNrLSGNSLANDDGHAEPSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.33|      19|      35|     775|     793|       7
---------------------------------------------------------------------------
  775-  793 (39.46/25.90)	VYGPKLRYVC.HLQ.WKPSER
  811-  831 (30.87/18.57)	VYFNPHSILCgHLQhWFNSVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.80|      12|      30|    1086|    1097|      10
---------------------------------------------------------------------------
 1086- 1097 (22.91/11.90)	CNQSEM....KFFLNE
 1115- 1130 (16.89/ 7.08)	CTEGDVqfleKYFLEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.21|      17|      53|     447|     464|      12
---------------------------------------------------------------------------
  447-  464 (30.22/23.47)	DLSMNLFTGKfVCR.LPAF
  503-  520 (30.99/18.42)	DHAMRFFTLK.VCEtLPAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.10|      20|      27|     679|     705|      13
---------------------------------------------------------------------------
  685-  705 (31.27/40.56)	HRLVwSMELNTVGSP.....LGDSSS
  711-  735 (29.83/13.97)	HRKI.TILTCTVGNEsarkcLDDVSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     162.11|      51|     445|      79|     134|      15
---------------------------------------------------------------------------
   79-  134 (71.45/61.86)	LDRKIsIAQFaHSARQLFVRLyAILKWARCGAKVDLCTGIVCflDQQASMFVDTAD
  530-  580 (90.66/55.98)	IDRRL.IIKF.HRFENYFIVL.TFNDHPDDSTKVNLDFWLVC..NETVSNAIRSAD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06346 with Med14 domain of Kingdom Metazoa
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