<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06345

Description Mediator of RNA polymerase II transcription subunit 14 (Fragment)
SequenceLFWMTSFNASLIKCTITKMSGDEESMDFEEKLAAFPLPSIPANQGPPFMAFGVLLDFAVQKTYQDFVILTDLLPKKSDLDRKISIAQFAHSARQLFVRLYAILKWARCGAKVDLCTGIVCFLDQQASMFVDTADRLYQMNCDVLQNARLPAFQIPTAVDVLTLGTYPRLPSVIKREFIRTADISQEEEECVLHRLNYVIERRLLPSLLTLPEGMRNFTVNNGMATFHVAGEFEAKLTLLGQLPRTPWTLLKLRILVSDPRVTDGSDVLSSLQLSYLHHLIQSRLNVSKEPIVELYRVIHCFCLSAQLDILCCQAYRLIGDFMSENLSVEEYISSEKLVISYWKERNQGGIASFKIIFWINQDEPFAPLQVSHIPKSDLKLPTMDTESGQLALDNLLTETVLIRVKHRLQQLCDFLLTIKGLTCTFISDMPALSVTFLPGSNSTEILDLSMNLFTGKFVCRLPAFGNKLHINPVVDHCFHGFILCFCFSDEDISLIAELTEKLDDNHWNCLEDLLHQIRVRIFMNRVDHAMRFFTLKVCETLPAFLKTTCEQWPIDRRLIIKFHRFENYFIVLTFNDHPDDSTKVNLDFWLVCNETVSNAIRSADDDDRSKKNVNLLHFDLRKFVSESKVKKQCVIPELMAAFSMCENAMPFFLLMEEMERTSARYAYHQLFDGTVVLRVLGIDQTCDHNFEKILGLPKGLAISLSYDRHRLVWSMELNTVGSPLGDSSSFGKAVHRKITILTCTVGNESARKCLDDVSSGVRCFSALYEPVKALARAYKGCLHRLTPLSMLSSYKLTLVYGPKLRYVCHLQWKPSERMYILSFGVDNSVLNEEYVYFNPHSILCGHLQHWFNSVRDISALSHLLQASSAALQALTTLPDTIFRVGSEHTSNQMLYLNRMFSILPTGPDTVRLLCKDHLCLEMRFTFSGSIFMRDCGSAFGLPQMKSVKYVPITGFKTFLNLHISEMKAAIEAERKVSTAVNDSFMEVSDVDFSGNTFQANSNSGTGSSMVLENSMRISTQNRLSGNSLANDDGHAEPSSRSPPEDWTPCVVPIEIQQNAFIRICSPSGTHPHPEWSHLQKFILSVEVLEKMKEQANNFTVIRPGQLSLKCNQSEMKFFLNESNLSSVMFKFFRDENDACTEGDVQFLEKYFLEQISSTYNATAMYAFVRMLTVCQTIRRDLLSSFLSIMNIQQHVYVESSTAYWIPEMCFLIPSPQLVPTTYLSRATLMPGGSAIVANVVQKKMLFWIKFVRVADPSHCVAFPFLYDGENNSLQVFRGTNQQTAQQSNNTVYPIETCLLRQQQTHSAFSECVVWPCIRDVMHINELIPGRS
Length1331
PositionTail
OrganismTrichinella papuae
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.10
Grand average of hydropathy-0.016
Instability index40.80
Isoelectric point6.28
Molecular weight151324.09
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06345
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.93|      22|     354|     456|     484|       1
---------------------------------------------------------------------------
  458-  481 (39.41/37.02)	VCR.LPAF....GNKLHINP..VVDhcFHGF
  537-  565 (31.52/ 8.46)	VCEtLPAFlkttCEQWPIDRrlIIK..FHRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.08|      25|      28|     874|     901|       2
---------------------------------------------------------------------------
  874-  901 (40.47/30.47)	LTTLPDTIFRVGSEHTSNQMLYlnrMFS
  903-  927 (47.61/27.97)	LPTGPDTVRLLCKDHLCLEMRF...TFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     167.74|      68|     886|     289|     390|       3
---------------------------------------------------------------------------
  298-  390 (85.70/133.72)	IHCFCLSAQlDIlccqayRLIGDfMSENLSVEEYISSEKL...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................visywkernqGG......IASFKIIFWINqdepFapLQVSHiPKSDLKLPTM.DTESGQL
  482-  513 (42.03/12.08)	ILCFCFSDE.DI......SLIAE.LTEKLDDNHWNCLEDL...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1231- 1273 (40.02/13.26)	........................................lhqirvrifmnrvdhamrfftlkvcetlpaflkttceqwpidrrliikfhrfenyfivltfndhpddstkvnldfwlvcnetvsnairsaddddrskknvnllhfdlrkfvseskvkkqcvipelmaafsmcenampffllmeemertsaryayhqlfdgtvvlrvlgidqtcdhnfekilglpkglaislsydrhrlvwsmelntvgsplgdsssfgkavhrkitiltctvgnesarkclddvssgvrcfsalyepvkalaraykgclhrltplsmlssykltlvygpklryvchlqwkpsermyilsfgvdnsvlneeyvyfnphsilcghlqhwfnsvrdisalshllqassaalqalttlpdtifrvgsehtsnqmlylnrmfsilptgpdtvrllckdhlclemrftfsgsifmrdcgsafglpqmksvkyvpitgfktflnlhisemkaaieaerkvstavndsfmevsdvdfsgntfqansnsgtgssmvlensmristqnrlsgnslanddghaepssrsppedwtpcvvpieiqqnafiricspsgthphpewshlqkfilsvevlekmkeqannftvirpgqlslkcnqsemkfflnesnlssvmfkffrdendactegdvqflekyfleqisstynatamyafvrmltvcqtirrdllssflsimniqqhvyvesstaywipemcflipspqlvpttylsratlmpGGsaivanVVQKKMLFWIK....F..VRVAD.PSHCVAFPFLyDGENNSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.47|      29|      30|     980|    1008|       4
---------------------------------------------------------------------------
  980- 1008 (49.82/30.73)	VNDSFMEVSDVD.FSGNTFQANSNSGTGSS
 1010- 1039 (44.65/26.81)	VLENSMRISTQNrLSGNSLANDDGHAEPSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.33|      19|      35|     799|     817|       5
---------------------------------------------------------------------------
  799-  817 (39.46/25.31)	VYGPKLRYVC.HLQ.WKPSER
  835-  855 (30.87/18.09)	VYFNPHSILCgHLQhWFNSVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.80|      12|      30|    1110|    1121|       9
---------------------------------------------------------------------------
 1110- 1121 (22.91/12.06)	CNQSEM....KFFLNE
 1139- 1154 (16.89/ 7.18)	CTEGDVqfleKYFLEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.10|      20|      27|     703|     729|      10
---------------------------------------------------------------------------
  709-  729 (31.27/33.34)	HRLVwSMELNTVGSP.....LGDSSS
  735-  759 (29.83/11.53)	HRKI.TILTCTVGNEsarkcLDDVSS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06345 with Med14 domain of Kingdom Metazoa
Unable to open file!