<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06333

Description Mediator of RNA polymerase II transcription subunit 15 (Fragment)
SequenceLLFFFINLQLFFLYCLSLIMEDDWRSQRQREKVIQHLDNVIRSCTVPLNIPGDARQVENAIFLKASNQEEYMQFVSKIIYHASSGAAAMSQPQRHQAPVNQVPYGNMQPGTQFRRADMRPMQQPMQQQQQQQQQQQQQQVPGQIYSGMRAPPNAEMQPRLLRPMHQPSVTMHHMHQQQAQMGQMGMTQSAGIAAAAQQQPQNVVMLLTSGNPPRQAASAPSAVQLRQPNDIQQFLQQLPPAIRQQILQLPPEEQAEQLKKFFESRRWQQQQQQLHQQQQIQQQQQQQQQQQQQQQQQQIQQQIQQHQQQQQQLQVQQQIQHQMHHVAQNQMHTQAVIQQQQQQQQQQQQQQQQQQQQHQQQFASVRQQQQMQMLQPMMQQPGAVRFADQSTTMLYSRPPATPVMIPQTPAPVQQPPSQPAPVTPMSGQAASPNVNIGTPYPSSSPAGAHMMGPSPAYAAETSPVCHPAATPGPKTSQMSPAANSLPPEGIGAEHSPYKEKVNELLVYLEPLKRLIEQTKESTSDSSQTQKFQRMVDILEGRNDTSMDVLLKCEETLKMICQKSDIIKVKDRNINQPLLDAISAITKPERQKINLYEYFNFPLYQCSLKNTCPDCLKGSCENETAQASNVEDSDQISIPLNIQREIGSLESKFRVTIDPSQRPLRSSCKFISVLCELLDITLPSVPPIYIRIPTNYPQSPPKYDLEWSQYCDSPYLNSIRKSLESFSSDTGAPNTISALLTNWETCVRDASFI
Length752
PositionTail
OrganismTrichinella nativa
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.06
Grand average of hydropathy-0.762
Instability index77.41
Isoelectric point7.67
Molecular weight85684.94
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06333
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     188.34|      22|      22|     269|     290|       1
---------------------------------------------------------------------------
  114-  135 (35.91/ 8.34)	RRADMRPM.QQPMQQQQQQQQ....QQ
  269-  290 (47.71/14.06)	QQQQQLHQ.QQQIQQQQQQQQ....QQ
  291-  317 (35.57/ 8.17)	QQQQQQQQiQQQIQQHQQQQQqlqvQQ
  327-  347 (33.74/ 7.28)	.AQNQMHT.QAVIQQQQQQQQ....QQ
  348-  368 (35.40/ 8.09)	QQQQQ.QQ.QQQHQQQFASVR....QQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     141.31|      37|      37|     410|     446|       2
---------------------------------------------------------------------------
  162-  212 (49.08/14.88)	RPMHQPS...............VTMHHMHQQQAQMGQ.MgmtqsagiAAAAQQ.QPQNVvmlltsG...NP
  410-  439 (48.95/14.82)	......................APVQQPPSQPAPVTP.M........SGQAAS.PNVNI......G...TP
  440-  496 (43.28/12.24)	YPSSSPAgahmmgpspayaaetSPVCHPAATPGPKTSqM........SPAANSlPPEGI......GaehSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.33|      28|      56|     550|     604|       3
---------------------------------------------------------------------------
  550-  582 (39.52/65.67)	LK..CEETLKMICQKSdiiKVKDRNINQPllDAIS
  607-  636 (45.82/16.68)	LKntCPDCLKGSCENE...TAQASNVEDS..DQIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.59|      10|      36|     100|     110|       4
---------------------------------------------------------------------------
  100-  110 (17.17/10.90)	NQVPyGNMQPG
  138-  147 (18.42/ 6.77)	QQVP.GQIYSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.88|      29|     157|     220|     250|       5
---------------------------------------------------------------------------
  220-  250 (48.17/28.66)	PSAVqlRQPNDIQQFLQQLPPAIRQQILQLP
  381-  409 (54.71/27.61)	PGAV..RFADQSTTMLYSRPPATPVMIPQTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.49|      10|      16|     642|     652|       8
---------------------------------------------------------------------------
  642-  652 (13.60/11.86)	QREIGSlESKF
  660-  669 (19.89/12.22)	QRPLRS.SCKF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06333 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSQPQRHQAPVNQVPYGNMQPGTQFRRADMRPMQQPMQQQQQQQQQQQQQQVPGQIYSGMRAPPNAEMQPRLLRPMHQPSVTMHHMHQQQAQMGQMGMTQSAGIAAAAQQQPQNVVMLLTSGNPPRQAASAPSAVQLRQPNDIQQFLQQ
2) QQQQQQQQQQQHQQQFASVRQQQQMQMLQPMMQQPGAVRFADQSTTMLYSRPPATPVMIPQTPAPVQQPPSQPAPVTPMSGQAASPNVNIGTPYPSSSPAGAHMMGPSPAYAAETSPVCHPAATPGPKTSQMSPAANSLPPEGIGAEHSP
89
347
237
496










Molecular Recognition Features






MoRF SequenceStartStop




NANANA