<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06325

Description Coiled-coil domain-containing protein 47
SequenceMMNSFILFILLPYFLFFYLDFFRRMQEVDKNFINSVGGIVQNIKSIQSSISEVLAKLQMVDQLDWPSLLNSFRVISSQFNSMLQLLRSDRASHFKNYVFLPIKLSVEVDADLEAATENRLHAWTHAVVPDYLRTKPDPQVEQKDQQISNQVQQRICNPESLQKQITAFNRCLNCILDSLNASIRDSEMDGRKTSKTSDGEDTALLVAAILKGQNVKPAYSATPASSRGSSGDSGHSKASKAQQVQCCFILKKQCMAKNKCSININQFTTEREEKVRRKTCIWMFFLSCLFEFVELSVKQVSQIDDNEFAEFEEFDVELDASVDADFTANNVNERETPPVDTASIGAKRSPAYAEQKRNDAPNSNFNDDDYGIVEDESVDDFSHLLDENEFENFPDERRPGKQNAGPSKTVTQLKITDVPGHLRNNWNNFVVELFLIFGLIVYVINYIYGKTKNHSLAVAWFDSNRPFLEENFSIVGDDGISPEVTKNVLIKESDNHYIVWCSGRQGCIGMEIHLKLIKRQDLLSLIFYIIRPKFDVIEIKIILNPEEMDPFVFALGTKRSAIKNSKEIMDLNLYCSEKKNVEKLGLPSSYILHSEIGEVTTGLIDTKIVSALCKYKDVVDYIHISDQFVGIKPIEMENMTKPPETAKVVMICLNIPGQLRATEEDVSSLQPLMIFIFHVLEKVRRFRLTREGKQKADKNRQYVEESFLKTTHAQRQEAAQQRREERARERKERLMAEEDPERQRKLEKQELKRELKKKQPRVKQIKIKAM
Length770
PositionHead
OrganismTrichinella nativa
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.08
Grand average of hydropathy-0.433
Instability index44.28
Isoelectric point6.21
Molecular weight88509.11
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro
rough endoplasmic reticulum membrane	GO:0030867	IEA:UniProtKB-SubCell

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06325
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     190.91|      62|     234|     406|     472|       1
---------------------------------------------------------------------------
  406-  472 (98.84/78.10)	PSKTVTQLKI.TDVPGHLRNNWNNF.VVELFLIFglIVYVINYI..YGKTKNHSLAVawfDSNRPFLEENF
  642-  707 (92.07/58.23)	PPETAKVVMIcLNIPGQLRATEEDVsSLQPLMIF..IFHVLEKVrrFRLTREGKQKA...DKNRQYVEESF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.74|      18|      26|     476|     494|       2
---------------------------------------------------------------------------
  476-  494 (27.32/21.78)	GDDG.ISPEVTKNvLIKESD
  503-  521 (28.42/17.66)	GRQGcIGMEIHLK.LIKRQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.75|      12|      26|     555|     566|       4
---------------------------------------------------------------------------
  555-  566 (19.41/10.70)	LGTKRSAIKNSK
  584-  595 (20.34/11.53)	LGLPSSYILHSE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06325 with Med8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NRQYVEESFLKTTHAQRQEAAQQRREERARERKERLMAEEDPERQRKLEKQELKREL
699
755










Molecular Recognition Features






MoRF SequenceStartStop




1) LKRELKKKQPRVKQIKIKAM
751
770