<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06313

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMASCTVAWEKKPLKRPRLGQPDDELTAEKVRQGFIYKPPLLNEYESLRSQRFDENLEDYFIKLTQSYNAIVNKKAEINALQDSYKKKSGFKEPSIWHFFIAPLAAKPKGQDTWFKDLSGNKPLSALGKRFPFLNKKDEILYTLAEFNVPMVRVVWFLKMTNAHIAQQQECGKMKKKHMSDPFADWTHLVMKYLRDLCSKLGEFFSLNLEVPMNSEFECHYRHWQYTTKLTRHLFEEGLLDKEMLLNGLLDIFAEKIYASSFGILKMLVPVLLQFIDGFVMSVLLSRRLVYLACKVLSAMKIDNLQNNSENMKEEEEEEEGTLDYLNCPFHRTVLFGLSNVIHAVLIDCPTALIWNEMECEDTGENGKAYLCGSPLDLLYCSPVDLPLFMDPSTEFVKKELERLTEMVTERSRAVESHWSYNKCQHSGLSESTIIQHFLSILDCLDKFKFEYVNETNNIDTLYKTIFQSEKKEMRVDVDSIAVQFLCHWAVSPHRYGSYRAAVVTRLFERHLQEVKHDEFQLSKKMPQVRHPFQKSLFNYLHNQAPNLGEMCSSSEIKPFTNLILLFSRLIESDIFSHDQYVSTLVSSGDLIPNGANIFYPLQNQCSSAAVENVSNTQPAVLMSSNFFSEQFKPIENVDFNYFKDSDESKLDFDKIIDFADKKAISSDTGENSCSSKRVPKLSKHYFNVLHFPVPQDDQYRHECNQRQLLLFGSNSDQYSRKHILKKLTKELNKLWNKKTSAELTTTGLIRVRKIIDSESLCSLSRKIQNLVFYDQFAVMDCCCDAGIAQFNSFISGQSNCLPTLENFDFLLGLLEESSNFISLVEFVEAIICLLPKLEAQIVERNFQCANSLTLQYAVCMVGYMRKHHCYFIQLESVMCNIWRSLLLYVKSKTVVNSFSAERCVWVYLHDLYQCCSYIRSLHADLYLNSRDCIQRCLCVETKPSCCNDLRTLLADVSQDIMLDVLFQESDLVIEPNLIQQLVENANLCYAFAIVAVKALCSLSGDTERLFNLVLFCADVTALCPNLNADWLAVFKILCCPFNSSQDQSSCDSLLNIDVSDHQCYQPLTVLVITLISRMCIRLEDFILHVAMPSLLPLWKHAGSAKVEKGSEASAKLTLHLLGKILLFFDYQGPKNALPAKTKGELSLICSSVDGMVPDAILTLLIAILMLDDSKVQELKSKENFDTKRSAAKQFVEEDTNTAGNSDIGSTAIQLLELICRQEWTKRKFLHSTDLFDPKRLLNPLVNQTQAQRLLRMITRSDSEILLKKFDSCTTKKELISKVLDSLTIMNLWVSQMDLQLLLKQVANSQSESLHLVDTIAKSCMEVFQPQATLAFGEPSDDKDEDAYLNASSFDEIAPYWLVAPLISRLPSFVQGRVLKAAVSILENCQARRDRNLFVQSSSLLAHQPFLSLVLICLRGQDDQREGLLSSLLKQIQEFVMRVKEDPYILCDRDIVSEMLDALQLRLSLIGGMFDTVCRNANLENWSLVMVQLLLYGIVTEEKNQALFYTCVDILCVLLLSCLLPDSAGFSFSGQERTNEDCKRIYNNVIKKLKVKEIGDRQVPSLRCVHQLLPIPRQMVDIIVCDEYGSQPQKGSRGGFSSSEVTQRKGLQIIGKEKLNPWEIIEGYNRENIGLKWSWFQGIRLDYQPETLFEQMMRMLPHDHHHAFNRPPMPGEPRSDPFLETLQVHYLPCTNETSDSDKLTTERLKSNGPVAISGGTLVSEFSDQVQSPRTTKARARKSTRGRKTSSRVTVSSNVALSSVPPMVQNRQLGIGQPTLTAHYGYYPQQVAMTGGPSGAVPPYGQGQMWSIGNVQSASTAVPPTQYQSRNFTGAQMTPVQSSSGKQAISAMIRGRRPSGSGGQQMMTTAHIQAAPLATGKPYHQQQLHSIGQVDPMVAPMHQVQMQMDARQQLMQESMMEQQQIRTPGPRSMATQQHCLPQVNSAASQPVMHGNYSNYPGQHGGGRMQMTSGRNQYAAQQPAQPPFNCSPNYNAQFYQAQNAGQMRMSQTDVIGQSNVRYTQQPNAIGSSYQMQSQQTLRAPAGYVAQQANPMYAAPNTPQYQAAQQQNVSMYPVSRMSQYSSNVPGQEMNASQQQMNYYPPQY
Length2103
PositionKinase
OrganismTrichinella nativa
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.09
Grand average of hydropathy-0.274
Instability index48.39
Isoelectric point6.50
Molecular weight238479.83
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06313
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     160.55|      26|      67|    1975|    2000|       1
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 1944- 1966 (35.54/17.11)	.AASQPVMHG.NY..S.NYPGQHGGGRM
 1975- 2000 (53.16/29.45)	YAAQQPAQPPFNC..SPNYNAQFYQAQN
 2011- 2034 (36.45/17.75)	VIGQSNVR..YTQ..QPNAIGSSYQMQS
 2044- 2068 (35.41/17.02)	YVAQQ.ANPMYAApnTPQYQAA..QQQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     126.61|      19|      36|    1762|    1780|       2
---------------------------------------------------------------------------
 1762- 1774 (18.39/ 7.53)	........................VPP.MVQNRQL.GIG
 1775- 1811 (27.42/15.55)	QPTLTAhygyypqqvamtggpsgaVPP.YGQGQMW.SIG
 1814- 1830 (17.84/ 7.04)	QSASTA..................VPPtQYQSRNF....
 1844- 1860 (18.84/ 7.93)	KQAISA......................MIRGRRPsGSG
 1863- 1890 (26.82/15.01)	QMMTTA.........hiqaaplatGKP.YHQQQLH.SIG
 1893- 1904 (17.30/ 6.56)	DPM.....................VAP.MHQVQM.....
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.66|      20|      67|     602|     621|       3
---------------------------------------------------------------------------
  602-  621 (34.54/21.92)	QNQCSSAAVENVSNTQPAVL
  670-  689 (36.12/23.29)	ENSCSSKRVPKLSKHYFNVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     524.23|     126|     191|    1215|    1343|       5
---------------------------------------------------------------------------
 1041- 1143 (129.01/91.03)	.............FNSSQDQSSCDSLLNIDV.....SDHQCYQPLTVLVIT....L.IS....RM..CIRLEDFILHVaM..PSL.................LPL..W.KHAGSAKVEKG.SEASAKLTLHL..LGKI.......LLFFdyqGP.KNAL.....PAKTKG
 1145- 1214 (61.02/37.07)	LSLIC...................SSVDGMV.....PDAILTLLIAILMLDDSKVQeLK....SKENFDTKRSAAKQF.VeeDTNTA...............GNS..DIGSTAIQL......................................................
 1215- 1343 (198.05/152.61)	LELICRQEWTKRKFLHSTDLFDPKRLLNPLV.....NQTQAQRLLRMITRSDSEIL.LK....KFDSCTTKKELISKV.L..DSLTI...............MNL..WVSQMDLQLLLKQ.VANSQSESLHL..VDTIaksC...MEVF...QP.QATLAF.GEPSDDKD
 1385- 1540 (136.15/96.60)	LE.NCQARRDRNLFVQSSSLLAHQPFLSLVLiclrgQDDQREGLLSSLLKQIQEFV.MRvkedPYILC..DRDIVSEM.L..DALQLrlsliggmfdtvcrnANLenW.SLVMVQLLLYGiVTEEKNQALFYtcVDIL...CvllLSCL...LPdSAGFSFsGQERTNED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.68|      18|     191|     810|     840|      10
---------------------------------------------------------------------------
  823-  840 (31.84/24.29)	LVEFVEAIICLLPKLEAQ
 1012- 1029 (31.85/ 9.37)	LVLFCADVTALCPNLNAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     160.26|      46|     191|     162|     225|      11
---------------------------------------------------------------------------
  174-  221 (75.41/85.81)	KKKHMSDPFADwTHLVMKYLRDLCSKLGEFFSLNLEVPMNSEfECHYR
  890-  935 (84.85/44.79)	KSKTVVNSFSA.ERCVWVYLHDLYQCCSYIRSLHADLYLNSR.DCIQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      53.40|      12|      28|    1695|    1706|      15
---------------------------------------------------------------------------
 1695- 1706 (19.18/11.09)	ETSD...SDKLTTER
 1723- 1737 (15.81/ 7.75)	EFSDqvqSPRTTKAR
 1739- 1750 (18.42/10.33)	RKST...RGRKTSSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.23|      24|      37|     747|     772|      16
---------------------------------------------------------------------------
  747-  772 (30.73/26.20)	GLIRVRKIIDSESLCsLSrKIQNLVF
  786-  809 (43.51/26.57)	GIAQFNSFISGQSNC.LP.TLENFDF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06313 with Med12 domain of Kingdom Metazoa
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