<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06304

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMLHILIKNTLLNHRISFWGFCAFVAMSVSLSDFEAKVKNLFKEHAKSGIAHFFFRPYLITSSEEYEKEIVISTANELMEIFTSLPQNLQESAFSIVISHRVLSNSANRIVDFFVRNVTQRQMLSIKCICEKLLTCAELNINSCGWNDTFAFFMENISLLDYKGVRDTLKRLLDIPIPVHLQVDQRKSVEAVEKLIKTICDRKNNLLPAYFVITEIIKNLPEQRCFSHWRMADCFTEIIESFRPLAQLNSVCGRTFMTPIPGHVGFYFNAFWKLEALSLRFPLKGLLPYSQDLLNPQMRLLTHVFMHYTYRDAIAVLLGTAKPEKSRIPYFEEVITEIILELMFTAECDHSQLNPQAWRIISTQIIYLTLQQSICFTRLVKILHTKLTHYPYRYARNQLMWCLFNFLSGGMQKYSVEEFAVILDLYRLLYTGRDIFTVSGSDSSCVLMLAPTCIWIHILKKSPSMEVELPPTVNTQRKFLQEALKNKTQFNTDNYMVAVLCNAYSSTSEIFQQDLLPILLENLDNTRGHNSTQASGNFASNATSSMPYPNGAVSEVKLRPLKLEFLDSVSVHVRMNIANSLIGTFGRFMQGKSAWPSPALVETYCRMLTYPDLEILGLKQFTSHIVLTAARHQCCEMMYICCEILNYRLFNIPSTYRVHAIVTLQQTLAFAKFQTNASLYWMLERTLLLQFQWYPHYEIFQAPFARLLNSFVAVAADGTKQSIAENEELMRIIILTLARSTVISSNCDSCFIEGVYRELLNKLPSYSWPQSTLSVFPQVFCSHYTQQQQQQQQQQQQQQQQQQQQPQQPQQQQQPQPQQSNVVVGSSQQPQQQQQSQVLGPRKVLVHLKSLADFLVYETNSADVNRCVDVLNRLIFKYAVVPLERFMLTMLLRDYEGNDAFYALLIVMLLVQRSEELRSAVADCVAMLPSDYWHCQDWNDKYQAYQIKHAERTWSQVYVELSRASLTPNDCPLPVYFGTRCLQMLPVVDLLLQKLVESPAACLKFLDSTLSILGPLYRFHPYPVSFLYSTFRFYEKRLVESPAIKQKLALAVHGACVPSRDDHWLLSAEFVGWVGQATDRGPWVPDLNYYGALVRRLIDTFSEPRQQWSRKTDLRFVEFNNFQTHALYSICIELMSLPVGVVDVGNALVTLVTHWHSLVDKNTVMYWVNAIGLIFSALPISYMEPFYQTILTTLCSDHMNSINTDVSNKLDFEKRSKLMEDCYPARILALCHAVWLHSTSGYLQLLPQALRSTWIPHVRSEGQFLYVCHLVAPFLQRFYQERTKFTMDITTDLYQMLYNVDCEVGNWKYEDLICDFFYHVKYMYVGDSVRQDTDRIIPMLRPSLQQKLRYISFAQGEQSAGTPFSEMINPIKLLGIQMVVWLQRLPIFGETAQHFWLAVTKLGDPVMTFSLYFPALFPFFGTAALDMVIVGAFSEISNCILKWILLDDRPYWWVHTAGVSGQLSHPLKQFQWTCETGPGSPSGHAMVSASVWFNLLYNLQSDLVLGDLCGICWLLYVVFLIAVSVSRTYISAHFPDQVILGIVVGICIALVTRSLVGHRRRRWSNLIAFMIALLLIALSVHEVHRFFGVDTHRSIELAAKYCHRAEWIHQSTTPLASFFRDVGVLISVAILLANKSMFTNNNKIASKFFSTKFAQALLGVGLNQLVAFIPIGRLPTALFYAVLLPALIVLLLTMVLDLDNFRVEKGGNVQAVRVSQQKRFQSVDLVDQVVETDQEWRRSRYLSDEWNRLKNLCSKEIGEKIKRKEPVDGNSTLPDSLTDKLQKVTVDQIRALSVSQIKQLRLLIDHEMEKSYKLVENLEAVRFKALSQIGNLVHNSVPVSENEDDNEIVRTWGELEVRKKYSQVDLGIMVDGYDSERGCSVAGSRGYFLKGPLVFLEQALIQLAMHMLFKKKYTPLYTPFFMRKEVMQEVAQLSDFDDQLYKVIGKSSEVKEEIAEEEKYLIATSEQPIAAYHRDEWISKESLPLRYVGFSTCFRQEVGSHGRDTSGIFRVHQFEKVEQFCITSPHDDASWEMLEEMISNAEMFYQTLNIPYRVVSIVSGELNNAAAKKYDLEAWFPGSGAFRELVSCSNCTDYQSRRLRIRYGQTKKMMAKAEFVHMLNGTMCATTRTICAILENFQEENGIAVPEALRQYMPDDYKDFIPFVKPAPKVEQAAKRGNKSATAEKSTQ
Length2187
PositionTail
OrganismTrichinella nativa
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.11
Grand average of hydropathy-0.036
Instability index43.91
Isoelectric point7.27
Molecular weight251131.49
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-KW
serine-tRNA ligase activity	GO:0004828	IEA:UniProtKB-EC

GO - Biological Process
seryl-tRNA aminoacylation	GO:0006434	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06304
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      93.93|      18|      18|     785|     802|       1
---------------------------------------------------------------------------
  785-  802 (36.93/18.43)	QQQQQQQQQQQQQQQQQQ
  803-  820 (37.13/18.56)	QQPQQPQQQQQPQPQQSN
  823-  836 (19.87/ 7.05)	VGSSQQPQQQQQSQ....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.16|      29|      34|    1214|    1247|       2
---------------------------------------------------------------------------
 1214- 1247 (46.67/42.40)	RSKLMEDCYP.ARILALCHAVwlhstSGYLQLLPQ
 1250- 1279 (51.49/32.58)	RSTWIPHVRSeGQFLYVCHLV.....APFLQRFYQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     166.08|      37|      40|     963|     999|       3
---------------------------------------------------------------------------
  894-  935 (30.33/14.12)	.......Y.EGNDAFYAL.LIVMLLVQRseeLRSAVAdcVAMLPSDywhCQ
  941-  971 (49.65/28.02)	Y....QAY.......QIK.HAERTWSQV...YVELSR..ASLTPND...CP
  972- 1008 (61.15/36.30)	L....PVY.FGTRCLQML.PVVDLLLQK...LVESPA..ACLKFLD...ST
 1009- 1042 (24.96/10.25)	LsilgPLYrFHPYPVSFLySTFRFYEKR...LVESPA..............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     281.95|      62|      84|    1525|    1588|       4
---------------------------------------------------------------------------
 1411- 1473 (76.53/58.84)	...YFPALFPffgtaalDMVIVGAFSEISNCILKWILLDDRPYWWVH.....TAGVSGQLS.HPLKQFqWTC
 1493- 1521 (25.58/12.33)	NLLY...NLQ.......SDLVLGDLCGICWLLYVVFLIA.................................
 1525- 1588 (98.97/86.16)	SRTYISAHFP.......DQVILGIVVGICIALVTRSLVGHRRRRWSNliAFMIALLLIALSVHEVHRF.FGV
 1610- 1645 (33.85/19.76)	STTPLASFFR.......D...VGVLISVAILLANKSMFTNNNKIAS..........................
 1647- 1688 (47.02/32.31)	...FFSTKFA........QALLGVGLNQLVAFIP...IG....RLPT..ALFYAVLLPALIV..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.72|      15|      84|     298|     312|       5
---------------------------------------------------------------------------
  298-  312 (28.85/18.63)	RLLTHVFMHYTYRDA
  380-  394 (28.86/18.64)	KILHTKLTHYPYRYA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.13|      41|      84|     137|     179|       6
---------------------------------------------------------------------------
  137-  179 (70.99/49.40)	ELNINSC..GW..NDTFAFFMEniSLLDYKGVRDTLKRLLDIPIPVH
  218-  262 (68.14/41.65)	NLPEQRCfsHWrmADCFTEIIE..SFRPLAQLNSVCGRTFMTPIPGH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     220.54|      46|      83|     570|     615|       7
---------------------------------------------------------------------------
  535-  568 (39.81/19.46)	............GNFASNATSSM.PYPNGAVSEVKLRPLK.LEFLDSV
  570-  615 (79.31/46.28)	VHVRMNIANSLIGTFGRFMQGKS.AWPSPALVETYCRMLT.YPDLEIL
  622-  651 (44.22/22.45)	SHI........VLTAARH........QCCEMMYICCEILN.YRLFNI.
  657-  699 (57.20/31.26)	VHAIVTLQQTL..AFAKFQTNASlYW...MLERTLLLQFQwYPHYEIF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.43|      31|     867|    1179|    1212|       8
---------------------------------------------------------------------------
 1179- 1212 (52.08/39.73)	ISYMEPFYQTI.....LTTLCSDHMNSIntdVSNKLDFE
 2037- 2072 (46.35/27.36)	ISNAEMFYQTLnipyrVVSIVSGELNNA...AAKKYDLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.91|      15|     867|    1104|    1118|       9
---------------------------------------------------------------------------
 1104- 1118 (29.02/17.01)	RQQWSRKTD..LRFVEF
 1973- 1989 (23.89/12.69)	RDEWISKESlpLRYVGF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.46|      18|      30|     322|     344|      10
---------------------------------------------------------------------------
  322-  344 (26.46/28.48)	PEKSRIpyfeeVITEIIL.....ELMFT
  354-  376 (29.00/16.03)	PQAWRI.....ISTQIIYltlqqSICFT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.35|      13|     597|    1477|    1489|      11
---------------------------------------------------------------------------
 1477- 1489 (25.25/17.23)	PGSPSGHAMVSAS
 2076- 2088 (25.10/17.07)	PGSGAFRELVSCS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06304 with Med23 domain of Kingdom Metazoa
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