<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06303

Description "Serine--tRNA ligase, cytoplasmic"
SequenceMLHILIKNTLLNHRISFWGFCAFVAMSVSLSDFEAKVKNLFKEHAKSGIAHFFFRPYLITSSEEYEKEIVISTANELMEIFTSLPQNLQESAFSIVISHRVLSNSANRIVDFFVRNVTQRQMLSIKCICEKLLTCAELNINSCGWNDTFAFFMENISLLDYKDLLNPQMRLLTHVFMHYTYRDAIAVLLGTAKPEKSRIPYFEEVITEIILELMFTAECDHSQLNPQAWRIISTQIIYLTLQQSICFTRLVKILHTKLTHYPYRYARNQLMWCLFNFLSGGMQKYSGKSAWPSPALVETYCRMLTYPDLEILGLKQFTSHIVLTAARHQCCEMMYICCEILNYRLFNIPSTYRVHAIAPFARLLNSFVAVAADGTKQSIAENEELMRIIILTLARSTVISSNCDSCFIEGVYRELLNKLPSYSWPQSTLSVFPQVFCSHYTQQQQQQQQQQQQQQQQQQQQPQQPQQQQQPQPQQSNVVVGSSQQPQQQQQSQVLGPRKVLVHLKSLADFLVYETNSADVNRCVDVLNRLIFKYAVVPLERFMLTMLLRDYEGNDAFYALLIVMLLVQRSEELRSAVADCVAMLPSDYWHCQDWNDKYQAYQIKHAERTWSQVYVELSRASLTPNDCPLPVYFGTRCLQMLPVVDLLLQKLVESPAACLKFLDSTLSILGPLYRFHPYPVSFLYSTFRFYEKRLVESPAIKQKLALAVHGACVPSRDDHWLLSAEFVGWVGQATDRGPWVPDLNYYGALVRRLIDTFSEPRQQWSRKTDLRFVEFNNFQTHALYSICIELMSLPVGVVDVGNALVTLVTHWHSLVDKNTVMYWVNAIGLIFSALPISYMEPFYQTILTTLCSDHMNSINTDVSNKLDFEKRSKLMEDCYPARILALCHAVWLHSTSGYLQLLPQALRSTWIPHVRSEGQFLYVCHLVAPFLQRFYQERTKFTMDITTDLYQMLYNVDCEVGNWKYEDLICDFFYHVKYMYVGDSVRQDTDRIIPMLRPSLQQKLRYISFAQGEQSAGTPFSEMINPIKLLGIQMVVWLQRLPIFGETAQHFWLAVTKLGDPLCFHFLAPLRWIWILLDDRPYWWVHTAGVSGQLSHPLKQFQWTCETGPGSPSGHAMVSASVWFNLLYNLQSDLVLGDLCGICWLLYVVFLIAVSVSRTYISAHFPDQVILGIVVGICIALVTRSLVGHRRRRWSNLIAFMIALLLIALSVHEVHRFFGVDTHRSIELAAKYCHRAEWIHQSTTPLASFFRDVGVLISVAILLANKSMFTNNNKIASKFFSTKFAQALLGVGLNQLVAFIPIGRLPTALFYAVLLPALIVLLLTMVLDLDNFRVEKGGNVQAVRVSQQKRFQSVDLVDQVVETDQEWRRSRYLSDEWNRLKNLCSKEIGEKIKRKEPVDGNSTLPDSLTDKLQKVTVDQIRALSVSQIKQLRLLIDHEMEKSYKLVENLEAVRFKALSQIGNLVHNSVPVSENEDDNEIVRTWGELEVRKKYSQVDLGIMVDGYDSERGCSVAGSRGYFLKGPLVFLEQALIQLAMHMLFKKKYTPLYTPFFMRKEVMQEVAQLSDFDDQLYKVIGKSSEVKEEIAEEEKYLIATSEQPIAAYHRDEWISKESLPLRYVGFSTCFRQEVGSHGRDTSGIFRVHQFEKVEQFCITSPHDDASWEMLEEMISNAEMFYQTLNIPYRVVSIVSGELNNAAAKKYDLEAWFPGSGAFRELVSCSNCTDYQSRRLRIRYGQTKKMMAKAEFVHMLNGTMCATTRTICAILENFQEENGIAVPEALRQYMPDDYKDFIPFVKPAPKVEQAAKRGNKSATAEKSTQ
Length1819
PositionTail
OrganismTrichinella nativa
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.11
Grand average of hydropathy-0.060
Instability index44.63
Isoelectric point7.14
Molecular weight209266.36
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-KW
serine-tRNA ligase activity	GO:0004828	IEA:UniProtKB-EC

GO - Biological Process
seryl-tRNA aminoacylation	GO:0006434	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06303
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.29|      24|      29|     433|     461|       1
---------------------------------------------------------------------------
  433-  461 (43.85/31.60)	PQvfcshYTQQQQQQQQQQ........QQQQQQQQQQ
  462-  493 (44.44/21.35)	PQ.....QPQQQQQPQPQQsnvvvgssQQPQQQQQSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.41|      47|      81|     537|     586|       2
---------------------------------------------------------------------------
  537-  586 (77.00/66.16)	VPLERFMLT...MLLRDYEGNDAFYALLIVMLLVQRseeLRSAVADCVAMLPS
  615-  664 (78.41/58.69)	VELSRASLTpndCPLPVYFGTRCLQMLPVVDLLLQK...LVESPAACLKFLDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     194.70|      61|      81|    1157|    1220|       3
---------------------------------------------------------------------------
 1157- 1220 (97.18/98.41)	SRTYISAHFPDqviLGIVVGICIALVTRSLVGHRRRRWSNLIAFMIALLLIALSVHEVHRFFGV
 1242- 1302 (97.52/88.45)	STTPLASFFRD...VGVLISVAILLANKSMFTNNNKIASKFFSTKFAQALLGVGLNQLVAFIPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     175.55|      53|      81|     128|     184|       4
---------------------------------------------------------------------------
  128-  184 (91.14/75.81)	ICEKLLT..CAELNINSCGWNdtfaFFMENISLLDYKDL..LNPQMRLLTHVFMHYTYRDA
  210-  266 (84.41/59.70)	ILELMFTaeCDHSQLNPQAWR....IISTQIIYLTLQQSicFTRLVKILHTKLTHYPYRYA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.84|      22|      80|     739|     763|       5
---------------------------------------------------------------------------
  739-  760 (40.59/26.22)	WVPDLNYYG.......ALVRRLIDTFSEP
  766-  794 (31.24/11.88)	RKTDLRFVEfnnfqthALYSICIELMSLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.20|      13|      33|     839|     851|       6
---------------------------------------------------------------------------
  839-  851 (25.37/15.51)	MEPFYQTILTTLC
  875-  887 (25.84/15.94)	MEDCYPARILALC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     195.24|      61|     252|     672|     736|       7
---------------------------------------------------------------------------
  672-  736 (102.69/56.51)	LYRFHpYPVSFLYstfRFYEKRLVESPAIKQKL.ALAVHGAC.VPSRDDHWLLSAEF.......VG.WVGQATDR
  921-  991 (92.55/41.98)	LYVCH.LVAPFLQ...RFYQERTKFTMDITTDLyQMLYNVDCeVGNWKYEDLICDFFyhvkymyVGdSVRQDTDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.41|      29|      34|    1039|    1072|       8
---------------------------------------------------------------------------
 1043- 1072 (49.88/43.67)	IFGETAQHFWLAVTKLGDPLCfHFLAPLRW
 1075- 1103 (55.53/31.94)	ILLDDRPYWWVHTAGVSGQLS.HPLKQFQW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     162.26|      53|     251|      59|     114|       9
---------------------------------------------------------------------------
   59-  114 (80.07/57.17)	ITSSEEYEKEIVISTAN....ELMEIFTSLpqnLQESAFSIVISHRVLSNSA.NRIVDFFV
  311-  368 (82.19/50.51)	ILGLKQFTSHIVLTAARhqccEMMYICCEI...LNYRLFNIPSTYRVHAIAPfARLLNSFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.08|       9|     368|    1230|    1239|      11
---------------------------------------------------------------------------
 1230- 1239 (15.69/12.43)	AKYcHRAEWI
 1601- 1609 (20.39/10.05)	AAY.HRDEWI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.07|      16|      28|       6|      23|      12
---------------------------------------------------------------------------
    6-   23 (24.74/24.17)	IKNTLLNHRISfwGFCAF
   37-   52 (28.33/17.55)	VKNLFKEHAKS..GIAHF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06303 with Med23 domain of Kingdom Metazoa
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