<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06295

Description Lysine-specific demethylase 8
SequenceMILLVRIGLALLQCCFGYTWSILECFFKKPKSVTDKVIVITGAARGIGKGLALLLAHLHAKIVLVDLDESTNKQTAEELRQETSACVYAYTADVTDPESMRQVANAIVTNPELGCPDVLVCSAGVLIPKLLEDHSDTIRAFYPYILKRGQGHIVAVSSYGGHFGNSYSCCYSASKFAVRGLMESLEWEIYDHGFGGEIKTTTIYPFFTRTDLLSSCNVTSDVIPVLTPEETSQGILKAILYEQTEAFIPFYGSLICYFFKGRTFKAIELEDFEAAVEICNFMLNFIWERLNTGHWSEVNISWRLLYTMVSLLLSIAHIANGRLKDALCSCDKGLLLGCPISGNILARLASLLHCKMIDTYPLEDMLINDKFDQALASMNDVCEHFEHSVPRVECPSLETFQRDFLIPQNPVVIEGALESWQAMEKWNIAYLMSKCAYRTVPIEIGSKYTNDEWSQKLLTVTDFVHEYFNPDAREKAYLAQHQLFEQITELKDDIAVPDYCCLQCAPEDVDINAWFGPANTVSPLHTDPRDNLFAQVFGQKYLRLCHPTATKNLYPITDGLMSNTSQIDMEKIDYEKFPLVKNVKFYETIVKPGDLLFIPKATGIACDVMSSAGSAAVQSSLASGLLPSPSNLYYQSLGHITGGEGISRNGSRTPVSQRRVGHFTRARHHSSCDVHSLCDGVTFERCFDSQLPPADPQIHAGGFKSGFPFSARSSSNSYRQPTLSSHLSHGNLGYLQSDCDWSADLDPLVKNGRGSNEAPGCGSVSKIVNGRMTTTNCCPADCDALREDLRVAMEKLNATMGSIKSFWSPELKRERALRKEETAKMNMLQEQLKLSLVNNQKQSVLIEQLQNELRFQCNSGRSRRFPDDGPLIGHEDYRTVCQERDMYRRDWLISSDAVKELQYQLESQRQLLLSKDESVKRLLEALHSKGVPASVAQSCAEMELAQNRIVELEEKCSRLQAHCDDLESHLQQSHDGLSSLRKDAVIESLQDEVASYEAELKRLRSGGAIHEREFTDKMVTDKEYQELKLKADKLELELGQKTVEIQALYTRLSTAEESASDFKKHLELMKESNASKDQQATLLQSDIDALRGKLESKNEMIDQKAQQITELQADKNRLLSELNLLNEQHRISEVGLSTKDRKIDLLEETIRERDCELNLIRTRLNSSPGVIQEKKLQDEINRLVQERDLWRKRFNEEHECLAIERKRDGEAHEKENKDLRIAIASLQKEISDRQVFIESQNEKINDMVRQTEALTKENSLYKELNKTNGVDLLKAEIERLNQAVDESRSEVDRLLKIIHNSEKEKNEGRESGNDSKRFHSNTENADYQSVLMHKDRRIEELEEALKESVSITAEREMAVAQQKLNSQRAEQRIAALKDELKTMQEQYDELSIQLKQLRQEKVQSDATIKTMQEERKRYVDEVMQLKGEVLLAAIEEKDAHIAFLENFHGRKSSEEIDNVKKQKEELLQRLKEENARRVKLHNDPTLNFTDHFPKRHWWPAMGIAWVYLYSDPEKSDRQDVLLDSLQTALDNMDAKQAGFFSLTSETFFSTTTTNAKPVHLFQSSEFPETTFVLVGDTLGSASTFLFAEKSITQMIRNLDGAYCTKPISKVECRGNKYVISDFTVRTSVATIASNFKGILVEIEYRPCVAMQLCGDLMKEFCTALLGSAASAPPTFVGLTKPNQRYVPIDTIFQYHCYFMHFRKMSVQTAGPNEQQSQAQPQPQQQQQQQPQQQQQQQQQQQQ
Length1742
PositionHead
OrganismTrichinella nativa
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.07
Grand average of hydropathy-0.467
Instability index48.19
Isoelectric point5.55
Molecular weight197704.86
Publications









Function






Annotated function


GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-SubCell
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
methyltransferase activity	GO:0008168	IEA:UniProtKB-KW
oxidoreductase activity	GO:0016491	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
methylation	GO:0032259	IEA:UniProtKB-KW
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06295
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     850.83|     219|     221|     892|    1112|       1
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  735-  894 (117.47/83.54)	......................................................................LQSDCDwsaDLDPLVKNgrgSNEapGCGSvskivngrmtttnccpadcdaLREDlrVAMEKLNATMGSI..KSfwspELKRER........ALRKEE.TAKMNMLQEQLKLSL........................VNNQKQSVLIEQLqnELRFQCNSGRSRR..F..PDDGPLIGH..EDYRTVC.QERDMYRRDW.....LIS
  897- 1120 (334.47/244.42)	AVKELQYQLES..QRQLLLSKDESVKRLLEAL.HSKGVPA....SVAQSCAEMELA.QNRIVELEEKCSRLQAHCD...DLESHLQQ...SHD..GLSS.....................LRKD..AVIESLQDEVASY..EA....ELKRLRSGG.....AIHEREFTDKMVTDKEYQELKLKADKLELELGQKTVEIQALYTRLSTAEESASDFKKHL..ELMKESNASKDQQATLLQSDIDALRGKL.ESKNEMIDQKAQQITELQadknrLLS
 1121- 1302 (209.76/151.31)	...ELNL.LNE..QHRI.................................SEVGLStKDRKIDLLEETIR.ERDCE..lNLIRTRLN...SSP..GVIQ.....................EKK........LQDEINRLvqER....DLWRKRFNEeheclAI.ERK.RDGEAHEKENKDLRIAIASLQKEISDRQVFIESQNEKINDMVRQTEALTKEN..SLYKELN..KTNGVDLLKAEIERLNQAVdESRSE.VDRLLKIIHNSE........
 1314- 1481 (189.13/135.39)	DSKRFHSNTENadYQSVLMHKDRRIEELEEALkESVSITAeremAVAQQKLNSQRA.EQRIAALKDELKTMQEQYD...ELSIQLKQ...LRQ....EK.....................VQSD..ATIKTMQEERKRY..VD....EVMQLKGEV.....LLAAIEEKDAHIA...FLE.NFHGRKSSEEIDNVKKQKEELLQRLK..EENARRVKLH..........................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     439.96|     164|     220|     113|     295|       2
---------------------------------------------------------------------------
  113-  225 (120.82/118.40)	...............................................................................................................LGCP...DVLVCSAGVLIPKLLedhsDTirafYP....YILKRGQGHIVAVSSYGGHFGNSYSC..CYSASKFAvRGLMESLEWEIYDhgfgGEIKTTTIYPFFTRTDLLSSCNVTSdvIPV
  226-  442 (245.99/186.26)	LTPEETSQGILKAILYEQtEAFIPfYGSLICYFFKGRTFKAI.ELEDFEAAVEICnfMLNFIWERLNTGHWsevniswrllytmvslllsiahiangrlkdalcscdkgllLGCPisgNILARLASLLHCKMI....DT....YPledmLINDKFDQALASMNDVCEHFEHSVPRveCPSLETFQ.RDFLIPQNPVVIE....GALESWQAMEKWNIAYLMSKCAYRT..VPI
  448-  514 (73.16/40.18)	YTNDEWSQKLLTVTDFVH.EYFNP.DAREKAYLAQHQLFEQItELKDDIAVPDYC..CLQCAPEDVDINAW..................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.74|      49|      98|     579|     633|       4
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  579-  633 (71.70/61.10)	LVKNVKF...YETIVKPGDllfiPK..ATGIACDVMSSAGSAA...VQSSLASGlLpSPSNL.Y
  677-  734 (73.04/44.02)	LCDGVTFercFDSQLPPAD....PQihAGGFKSGFPFSARSSSnsyRQPTLSSH.L.SHGNLgY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.42|      15|      18|    1535|    1552|       5
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 1535- 1552 (17.87/19.15)	KQAGFFSlTSEtfFSTTT
 1556- 1570 (28.54/15.85)	KPVHLFQ.SSE..FPETT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.76|      17|     447|     315|     331|       6
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  315-  331 (32.01/21.32)	IAHIANGRLKDALC...SCD
  764-  783 (27.75/17.43)	VSKIVNGRMTTTNCcpaDCD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06295 with Med20 domain of Kingdom Metazoa
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