<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06288

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMNDRNNLVSSFPAPPIHYISQCTDSNIKDNLILPPPPPIQGAYTMFGVQYNTEDMIIQPLENQGIRRLYPNTPNFDRKVELKKLNHSIIANFLDLLEILIRCPSSPERERKIEDLSLLFINFHHLVNEFRPHQACQSLMLMLERQYKERMCYVNHFRDHFQAVEENLSNCLDNFPDQLEIKFLNDPTLKKIWIDCMQKSHTKRSESEKSNQIVEMKIDPEDIALCHLADKIVYGNYYSMNEFKIIKLFHLCCQLVRFSVEPRPMGLLVTKLWRWLFNNQEHKVIIVGLDNAGKTTILYHFLMDEVVHTSPTIGSNVEEVVWKNIHFLMWDIGGQDSLRASWNTYYTNTEFVILVIDSADRERLSTIKEEFYRMLAHEELRKSAVLIFANKQDIKKSMTSAEISHELNLTSIKDQRWQIQACCALTGEDFCLFYITVAPMRLCALKHSTSCVHCAGLQLFFVYFNATNKYLFSYIFRLH
Length478
PositionMiddle
OrganismTrichinella zimbabwensis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.11
Grand average of hydropathy-0.221
Instability index41.34
Isoelectric point6.44
Molecular weight56036.14
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GTP binding	GO:0005525	IEA:UniProtKB-KW
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06288
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.43|      11|      25|     126|     136|       2
---------------------------------------------------------------------------
  126-  136 (23.69/14.16)	VNEFRPH.QACQ
  153-  164 (17.75/ 9.08)	VNHFRDHfQAVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.24|      11|      22|     222|     232|       3
---------------------------------------------------------------------------
  222-  232 (19.55/10.11)	IALCHLADKIV
  245-  255 (21.69/11.92)	IKLFHLCCQLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.40|      12|      22|      28|      41|       6
---------------------------------------------------------------------------
   28-   41 (19.10/17.54)	KDNLIlpPPPPIQG
   53-   64 (22.30/12.61)	EDMII..QPLENQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.18|      19|      23|     327|     345|       7
---------------------------------------------------------------------------
  327-  345 (36.03/34.93)	LMWDIGGQDSLRASWNTYY
  353-  371 (30.15/27.80)	LVIDSADRERLSTIKEEFY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06288 with Med7 domain of Kingdom Metazoa
Unable to open file!