<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06283

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMASCTVAWEKKPLKRPRLGQPDDELTAEKVRQGYIYKPPLLNEYESLRSQRFDENLEDYFIKLTQSYNAIVNKKAEINALQDSYKKKSGFKEPSIWHLAAKPKGQDTWFKDLSGNKPLSALGKRFPFLNKKDEILYTLAEFNVPMVRVVWFLKMTNAHIAQQQECGKMKKKHMSDPFADWTHLVMKYLRDLCSKLGEFFSLSLEVPMNSEFECHYRHWQYTTKLTRHLFEEGLLDKEILLNGLLDIFAEKIYASSFGILKMIVPVLLQFIDGFVMSVLLSRRLVYLACKVLSAMKIDNLQNDSENMKEGTLDYLNCPFHRTVLLGLSNVVHSVLIDCPTALIWNEMECEDTGENGKAYLCGSPLDLLYCSPVDLPLFVDPSTEFVKKELERLTEMVTERSRAVESHWSYNKCQHSGLSTIIQHFLSILDCLDKFKFEYVNETNNIDTLYKTIFQSEKKEIRVDMDSIAVQFLCHWAVSPHRYGSYRAAVVTRLFERHLQELSKKMPQVRYPFQKSLFNYLHNQAPNLGEMCSSSEIKPFTNLILLFSRLIESDIFSHDQYVSTLVSSGDLIPNGANVFYPLQNQCSSSASAVENVSNTQTAVLMSNNFFSEHFKPIENVDFNYFKDSDESKLDFDRIIDFADKKAISSDADSCSSKRVPKLSKHYFNVLHFPVPQDDQYRHECNQRQLLLFGSNFDQYSRKHILKKLTKELNKLWSKKTSAELTTTGLIRVRKIIDSESLCSLSRKIQNLVFYDQFAVMDCCCDAGIVQFNSFINGQSNCLPTLENFDFLLGLLEESSNFISLVEFMEAVICLLPKLEAQIVERNFQGANSLTLQYAVCMVGYMRKHHCYFIQLESVMCNIWRSLLLYVKSKTVVNSFSAERCVWVYLHDLYQCCSYIRSLHADLYLNSRDCIQRCLCVETKPSSCNDLRGLLADVSQEIMLDVLFQESDLVIEPNLIQRLVENANLCYAFAIVAVKALCGLSGDTERLFNLVLFCADVTALCPNLNADWLAVFKILCCPFNSSQDQTSCDSLLNIDVSDHQCYQPLTVLAITLISRMCIRLEDFILHVAMPSLLPLWKHAGSAKVEKGPEASAKLTLHLLGKILLFFDYQGPKNALPAKTKGELSLICSSVDGMVPDAILTLLIAILMLDDSKVQELKSKENFDTKRSAKQFVEEDTNTAGNSDIGSTAIQLLELICRQEWTKRKFLHSTDLFDPKRLLNPLVNQTQAQRLLRMITRSDSEILLKKFDSCTTKKELISKVLDSLTIMNLWVSQMDLQLLLKQVANSQSESLHLVDTIAKSCMEVFQPQATLTFGEPSDDKDENAYLNALSFDEIAPYWLVAPLISRLPSFVQGRVLKAAVSILENCQARRDRNLFAQSSSLLAHQPFLSLVLICLRGQDDQREGLLSSLLKQIQEFVMRVKEDPYILCDRDIVSEMLDALQLRLSLIGGMFDTVCRNANLENWSLVMVQLLLYGIVTEEKNQALFYTCVDILCVLLLSCLLPDSAGFSFSGQERTNEDCKRIYNNVIKKLKKEIGDRQMPSLRCVHQLLPIPRQMVDVIVCDEYGLQPQKGSRGGFSSSEVTQRKGLQIIGKEKLNPWEIIEGYNRENIGLKWSWFQGIRLDYQPETLFEQMMRMLPHDHHHAFNRPPMPGEPRSDPFLETLQVHYVPCTNETSDSDKLTTERLKSNGSVAISGGTLVSEFSDQVQSPRTTKARPRKSTRGRKSSSRVTVSSNVALSSVPPMVQNRQLSIGQPTITAHYGYFPQQVAMTGGPSGAVPPYGQGQMWSIGNVQSASTAVPPTQYQSRNFTGAQMAPMQSSSGKQAISAMIRGRRPSGSGGQQMMSAAHIQPAPLAAGQPYHQQQLHSIGQVDPMVAPMHQVQMQMDAVSLTNFTTFVRFVFCLIFVLHYFSFQRQQLMQESMMEQQMRTPGPRSMATQQHCLPQVNSAASQPVMHGNYSNYPGQHGAARMQITSGRNQYVAQPAQPPFNCSPNYNAQFYQAQNAGQMRMPQTDVIAQSNVRLLLCRYTQQPNYQMQSQQTLRAPAGYVAQQANPMYAAPNTPQYQAAQQQNVSMYPVSRMSQYSSNVPGQEMNASQQQINYYPPQY
Length2105
PositionKinase
OrganismTrichinella zimbabwensis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.09
Grand average of hydropathy-0.233
Instability index47.06
Isoelectric point7.12
Molecular weight239003.03
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06283
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     157.54|      42|      47|    1203|    1244|       1
---------------------------------------------------------------------------
 1158- 1199 (25.96/11.80)	.....LKSKENFDTKRSAkqfveedtntagNSDIGSTAIQ.LLELICR......
 1203- 1244 (70.98/45.88)	TKRKFLHSTDLFDPKRLL............NPLVNQTQAQRLLRMITRSDSEIL
 1253- 1292 (60.60/38.02)	TKKELI..SKVLDSLTIM............NLWVSQMDLQLLLKQVANSQSESL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     687.48|     173|     193|     422|     610|       2
---------------------------------------------------------------------------
  422-  604 (276.87/202.25)	QHFLSIldclDKFKFEYVNETNNIDTLYKTIFQ.SEKKEIRVDMDSIAVQ.........F.LCHWAVS..PHRYGSYRAAVVTR...LFERHLQELSKKmPQVRYPFQKS.LFNYLHNQAPNLGEM.CSSSEIKPF....TNLILLFSRLIESDIFSHDQY.VSTLVSSGDLIPNGANVFYPLQNQCSSSASAVENVSntqtaVLM
  611-  791 (237.79/163.91)	EHFKPI....ENVDFNYFKDSDESKLDFDRIIDfADKKAISSDADSCSSKrvpklskhyFnVLHFPV...PQD.DQYRHECNQRqllLFGSNFDQYSRK..HILKKLTKE.L.NKLWSKKTS.AEL.TTTGLIRVRkiidSESLCSLSRKIQNLVF.YDQFaVMDCCCDAGIVQ..FNSFINGQSNCLPT...LENFD.....FLL
 1945- 2072 (172.82/106.27)	............................................NSAASQ.........P.VMHGNYSnyPGQHGAARMQITS......GRN.QYVAQ..P.AQPPFNCSpNYNAQFYQAQNAGQMrMPQTDVIAQ....SNVRLLLCRYTQQPNYQM.QS.QQTLRAPAGYVAQQANPMYAAPNTPQYQAAQQQNVS........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     615.31|     195|     698|     169|     390|       3
---------------------------------------------------------------------------
  169-  390 (306.52/275.09)	KKKHMSDPFADwTHLVMKYLRDLCSKLGEFFSLSLEVPMNSEfECHYRHWQYTTKLTRHLFEEGLL...DKEILLNGLldifaekiyassFGILKMIV.PVLLQfidGFVMSVLLSRRLVYLACKVLSAmkidnLQNDSENMKEGTL...DYLN.CPFHRTVLLGlsnvVHSVLIdCPTALIWNEMECED.TGENGKAYLCGSPLD.................LLYCS.PVDLPLFVDPSTEFVKKELE
  870- 1091 (308.78/212.10)	KSKTVVNSFSA.ERCVWVYLHDLYQCCSYIRSLHADLYLNSR.DCIQRCLCVETKPSSCNDLRGLLadvSQEIMLDVL............FQESDLVIePNLIQ...RLVENANLCYAFAIVAVKALCG.....LSGDTERLFNLVLfcaDVTAlCPNLNADWLA....VFKILC.CPFNSSQDQTSCDSlLNIDVSDHQCYQPLTvlaitlisrmcirledfILHVAmPSLLPLWKHAGSAKVEKGPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.81|      35|      35|    1682|    1716|       4
---------------------------------------------------------------------------
 1682- 1716 (57.05/37.93)	TERLKSNGSVAISGGTLVSEFSDQVQSPRTTKARP
 1720- 1754 (57.75/38.50)	TRGRKSSSRVTVSSNVALSSVPPMVQNRQLSIGQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.83|      13|      17|    1847|    1863|       5
---------------------------------------------------------------------------
 1847- 1863 (17.31/18.38)	H....IQpaPLAAgqPYHQQQ
 1865- 1881 (21.52/ 8.69)	HsigqVD..PMVA..PMHQVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.30|      31|      42|    1598|    1628|       6
---------------------------------------------------------------------------
 1598- 1628 (60.17/44.19)	PWEIIEGYNRENI.GLKWS..WFQGIRLDYQPET
 1638- 1671 (52.13/37.09)	PHDHHHAFNRPPMpGEPRSdpFLETLQVHYVPCT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.25|      13|      18|    1771|    1784|       7
---------------------------------------------------------------------------
 1771- 1784 (23.44/18.73)	G...GPSGAVPPyGQGQ
 1789- 1804 (20.81/10.22)	GnvqSASTAVPP.TQYQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.48|      28|      32|    1368|    1397|       9
---------------------------------------------------------------------------
 1368- 1397 (43.32/36.02)	QARRDRNLFaqSSSLLAHQPFLSLV.....LICLR
 1399- 1431 (42.16/27.96)	QDDQREGLL..SSLLKQIQEFVMRVkedpyILCDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     146.23|      35|     604|     834|     868|      10
---------------------------------------------------------------------------
  801-  832 (23.60/10.03)	....ISLVEFMEAVICLLPKLEAqiVERNFQgaNSL...
  834-  868 (66.05/42.14)	LQYAVCMVGYMRKHHCYFIQLES..VMCNIW..RSLLLY
 1441- 1474 (56.58/34.98)	LQLRLSLIGGMFDTVCRNANLEN...WSLVM..VQLLLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.05|      12|      17|    1815|    1827|      12
---------------------------------------------------------------------------
 1815- 1827 (17.15/11.72)	PmQSSSGKQAISA
 1834- 1845 (23.89/11.77)	P.SGSGGQQMMSA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06283 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GTLVSEFSDQVQSPRTTKARPRKSTRGRKSSSRVTVSSNVALSSVPPMVQNRQLSI
2) RMLPHDHHHAFNRPPMPGEPRSDPFLETLQ
1696
1635
1751
1664










Molecular Recognition Features






MoRF SequenceStartStop




1) YYPPQY
2100
2105