<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06282

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMASCTVAWEKKPLKRPRLGQPDDELTAEKVRQGYIYKPPLLNEYESLRSQRFDENLEDYFIKLTQSYNAIVNKKAEINALQDSYKKKSGFKEPSIWHLAAKPKGQDTWFKDLSGNKPLSALGKRFPFLNKKDEILYTLAEFNVPMVRVVWFLKMTNAHIAQQQECGKMKKKHMSDPFADWTHLVMKYLRDLCSKLGEFFSLSLEVPMNSEFECHYRHWQYTTKLTRHLFEEGLLDKEILLNGLLDIFAEKIYASSFGILKMIVPVLLQFIDGFVMSVLLSRRLVYLACKVLSAMKIDNLQNDSENMKEGTLDYLNCPFHRTVLLGLSNVVHSVLIDCPTALIWNEMECEDTGENGKAYLCGSPLDLLYCSPVDLPLFVDPSTEFVKKELERLTEMVTERSRAVESHWSYNKCQHSGLSTIIQHFLSILDCLDKFKFEYVNETNNIDTLYKTIFQSEKKEIRVDMDSIAVQFLCHWAVSPHRYGSYRAAVVTRLFERHLQELSKKMPQVRYPFQKSLFNYLHNQAPNLGEMCSSSEIKPFTNLILLFSRLIESDIFSHDQYVSTLVSSGDLIPNGANVFYPLQNQCSSSASAVENVSNTQTAVLMSNNFFSEHFKPIENVDFNYFKDSDESKLDFDRIIDFADKKAISSDADSCSSKRVPKLSKHYFNVLHFPVPQDDQYRHECNQRQLLLFGSNFDQYSRKHILKKLTKELNKLWSKKTSAELTTTGLIRVRKIIDSESLCSLSRKIQNLVFYDQFAVMDCCCDAGIVQFNSFINGQSNCLPTLENFDFLLGLLEESSNFISLVEFMEAVICLLPKLEAQIVERNFQGANSLTLQYAVCMVGYMRKHHCYFIQLESVMCNIWRSLLLYVKSKTVVNSFSAERCVWVYLHDLYQCCSYIRSLHADLYLNSRDCIQRCLCVETKPSSCNDLRGLLADVSQEIMLDVLFQESDLVIEPNLIQRLVENANLCYAFAIVAVKALCGLSGDTERLFNLVLFCADVTALCPNLNADWLAVFKILCCPFNSSQDQTSCDSLLNIDVSDHQCYQPLTVLAITLISRMCIRLEDFILHVAMPSLLPLWKHAGSAKVEKGPEASAKLTLHLLGKILLFFDYQGPKNALPAKTKGELSLICSSVDGMVPDAILTLLIAILMLDDSKVQELKSKENFDTKRSAKQFVEEDTNTAGNSDIGSTAIQLLELICRQEWTKRKFLHSTDLFDPKRLLNPLVNQTQAQRLLRMITRSDSEILLKKFDSCTTKKELISKVLDSLTIMNLWVSQMDLQLLLKQVANSQSESLHLVDTIAKSCMEVFQPQATLTFGEPSDDKDENAYLNALSFDEIAPYWLVAPLISRLPSFVQGRVLKAAVSILENCQARRDRNLFAQSSSLLAHQPFLSLVLICLRGQDDQREGLLSSLLKQIQEFVMRVKEDPYILCDRDIVSEMLDALQLRLSLIGGMFDTVCRNANLENWSLVMVQLLLYGIVTEEKNQALFYTCVDILCVLLLSCLLPDSAGFSFSGQERTNEDCKRIYNNVIKKLKKEIGDRQMPSLRCVHQLLPIPRQMVDVIVCDEYGLQPQKGSRGGFSSSEVTQRKGLQIIGKEKLNPWEIIEGYNRENIGLKWSWFQGIRLDYQPETLFEQMMRMLPHDHHHAFNRPPMPGEPRSDPFLETLQVHYVPCTNETSDSDKLTTERLKSNGSVAISGGTLVSEFSDQVQSPRTTKARPRKSTRGRKSSSRVTVSSNVALSSVPPMVQNRQLSIGQPTITAHYGYFPQQVAMTGGPSGAVPPYGQGQMWSIGNVQSASTAVPPTQYQSRNFTGAQMAPMQSSSGKQAISAMIRGRRPSGSGGQQMMSAAHIQPAPLAAGQPYHQQQLHSIGQVDPMVAPMHQVQMQMDARQQLMQESMMEQQMRTPGPRSMATQQHCLPQVNSAASQPVMHGNYSNYPGQHGAARMQITSGRNQYVAQPAQPPFNCSPNYNAQFYQAQNAGQMRMPQTDVIAQSNVRYTQQPNYQMQSQQTLRAPAGYVAQQANPMYAAPNTPQYQAAQQQNVSMYPVSRMSQYSSNVPGQEMNASQQQINYYPPQY
Length2074
PositionKinase
OrganismTrichinella zimbabwensis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.09
Grand average of hydropathy-0.258
Instability index47.39
Isoelectric point6.94
Molecular weight235245.52
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06282
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.32|      23|      32|    1944|    1966|       1
---------------------------------------------------------------------------
 1956- 1990 (31.31/16.88)	PAQPPFNCSPNynaqfyqaqnagQMRM....PQ.TDVIAQ
 2027- 2054 (25.53/12.13)	PNTPQYQAAQQ............QNVSmypvSRmSQYSSN
 2056- 2074 (22.48/ 9.62)	PGQ.EMNAS.Q...........qQINY....YP.PQY...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.84|      28|      36|     848|     883|       2
---------------------------------------------------------------------------
  851-  866 (19.57/10.50)	..................FIQLESVM..CNIWRSLL
  867-  902 (36.26/28.20)	LYVKSKTVVnsfsaERCvWVYLHDLYqcCSYIRSLH
  905-  933 (47.01/25.21)	LYLNSRDCI.....QRClCVETKPSS..CNDLRGLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     164.39|      35|      35|    1682|    1716|       3
---------------------------------------------------------------------------
 1682- 1716 (56.30/35.30)	TERLKSNGSVAISGGTLVSEFSDQVQSPRTTKAR..P
 1720- 1754 (55.22/34.48)	TRGRKSSSRVTVSSNVALSSVPPMVQNRQLSIGQ..P
 1782- 1815 (52.87/32.67)	QGQMWSIGNVQ.SASTAVP..PTQYQSRNFTGAQmaP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     523.29|     177|     191|    1133|    1322|       4
---------------------------------------------------------------------------
  213-  299 (27.80/ 7.93)	............................................................................CHyRHWqytTKlTRHLFEEGLLDKEI.LLNGLLdifaEKIYASSfgILKMIV........PVLLQFIDgfvmSVLLSRRLVylaCKVLSAM.KIDNL..............................................................
 1133- 1322 (276.92/236.30)	DGMVPDAILTL.LIAILmlddskVQELKSkenFDTKRSAKQFVEEDTNTAGNSD..........IGSTAIQLLELICR.QEW...TK.RKFLHSTDLFDPKR.LLNPLV....NQTQAQR..LLRMITRS....DSEILLKKFD....SCTTKKELI...SKVLDSL.TIMNL..WvSQMDLQLLLKQ.VANSQSESLHL..VDTIaksC...MEVFQP.QATLTF.GEPSDDKD
 1328- 1519 (218.57/158.15)	NALSFDEIAPYwLVAPL......ISRLPS...FVQGRVLKAAVSILENCQARRDrnlfaqssslLAHQPFLSLVLIC..............LRGQD..DQREgLLSSLL....KQIQ.EF..VMRVKEDPyilcDRDIVSEMLD....ALQLRLSLI...GGMFDTVcRNANLenW.SLVMVQLLLYGiVTEEKNQALFYtcVDIL...CvllLSCLLPdSAGFSFsGQERTNED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     503.56|     168|     193|     422|     610|       5
---------------------------------------------------------------------------
  422-  610 (244.91/198.57)	QHFLSIldclDKFKFEYVNETNNIDTLYKTIFQ.SEKKEIRVDMDSIAVQ.........F.LCHWAVsPHRyGSYRAAVVTR...LFERHLQELSKKmpQVRYPFQKSLfNYLHNQAPNlGEMCSSSEIKPF....TNLILLFSRLIESDIFsHDQY.VSTLVSSGDLIPngANVFYPLQNQCSSSasaVENVSntqtaVLM.....SNNFFS
  611-  802 (258.64/152.18)	EHFKPI....ENVDFNYFKDSDESKLDFDRIIDfADKKAISSDADSCSSKrvpklskhyFnVLHFPV.PQD.DQYRHECNQRqllLFGSNFDQYSRK..HILKKLTKEL.NKLWSKKTS.AELTTTGLIRVRkiidSESLCSLSRKIQNLVF.YDQFaVMDCCCDAGIVQ..FNSFINGQSNCLPT...LENFD.....FLLglleeSSNFIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.73|      29|      47|    1840|    1871|       6
---------------------------------------------------------------------------
 1840- 1869 (52.25/38.71)	QQMMSAAHIQP.APLAAGQP........YHQQ......QLHSiGQ
 1906- 1949 (35.48/15.44)	RSMATQQHCLPqVNSAASQPvmhgnysnYPGQhgaarmQITS.GR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.95|      22|      47|     944|     971|       7
---------------------------------------------------------------------------
  944-  971 (34.72/33.98)	VLFQESDLVIEPNLiqrlveNAN.......LCYAF
  993- 1021 (38.24/23.35)	VLFCADVTALCPNL......NADwlavfkiLCCPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.30|      31|      40|    1598|    1628|       8
---------------------------------------------------------------------------
 1598- 1628 (60.17/38.96)	PWEIIEGYNRENI.GLKWS..WFQGIRLDYQPET
 1638- 1671 (52.13/32.70)	PHDHHHAFNRPPMpGEPRSdpFLETLQVHYVPCT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06282 with Med12 domain of Kingdom Metazoa
Unable to open file!