<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06281

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMASCTVAWEKKPLKRPRLGQPDDELTAEKVRQGYIYKPPLLNEYESLRSQRFDENLEDYFIKLTQSYNAIVNKKAEINALQDSYKKKSGFKEPSIWHLAAKPKGQDTWFKDLSGNKPLSALGKRFPFLNKKDEILYTLAEFNVPMVRVVWFLKMTNAHIAQQQECGKMKKKHMSDPFADWTHLVMKYLRDLCSKLGEFFSLSLEVPMNSEFECHYRHWQYTTKLTRHLFEEGLLDKEILLNGLLDIFAEKIYASSFGILKMIVPVLLQFIDGFVMSVLLSRRLVYLACKVLSAMKIDNLQNDSENMKEGTLDYLNCPFHRTVLLGLSNVVHSVLIDCPTALIWNEMECEDTGENGKAYLCGSPLDLLYCSPVDLPLFVDPSTEFVKKELERLTEMVTERSRAVESHWSYNKCQHSGLSTIIQHFLSILDCLDKFKFEYVNETNNIDTLYKTIFQSEKKEIRVDMDSIAVQFLCHWAVSPHRYGSYRAAVVTRLFERHLQELSKKMPQVRYPFQKSLFNYLHNQAPNLGEMCSSSEIKPFTNLILLFSRLIESDIFSHDQYVSTLVSSGDLIPNGANVFYPLQNQCSSSASAVENVSNTQTAVLMSNNFFSEHFKPIENVDFNYFKDSDESKLDFDRIIDFADKKAISSDADSCSSKRVPKLSKHYFNVLHFPVPQDDQYRHECNQRQLLLFGSNFDQYSRKHILKKLTKELNKLWSKKTSAELTTTGLIRVRKIIDSESLCSLSRKIQNLVFYDQFAVMDCCCDAGIVQFNSFINGQSNCLPTLENFDFLLGLLEESSNFISLVEFMEAVICLLPKLEAQIVERNFQGANSLTLQYAVCMVGYMRKHHCYFIQLESVMCNIWRSLLLYVKSKTVVNSFSAERCVWVYLHDLYQCCSYIRSLHADLYLNSRDCIQRCLCVETKPSSCNDLRGLLADVSQEIMLDVLFQESDLVIEPNLIQRLVENANLCYAFAIVAVKALCGLSGDTERLFNLVLFCADVTALCPNLNADWLAVFKILCCPFNSSQDQTSCDSLLNIDVSDHQCYQPLTVLAITLISRMCIRLEDFILHVAMPSLLPLWKHAGSAKVEKGPEASAKLTLHLLGKILLFFDYQGPKNALPAKTKGELSLICSSVDGMVPDAILTLLIAILMLDDSKVQELKSKENFDTKRSAKQFVEEDTNTAGNSDIGSTAIQLLELICRQEWTKRKFLHSTDLFDPKRLLNPLVNQTQAQRLLRMITRSDSEILLKKFDSCTTKKELISKVLDSLTIMNLWVSQMDLQLLLKQVANSQSESLHLVDTIAKSCMEVFQPQATLTFGEPSDDKDENAYLNALSFDEIAPYWLVAPLISRLPSFVQGRVLKAAVSILENCQARRDRNLFAQSSSLLAHQPFLSLVLICLRGQDDQREGLLSSLLKQIQEFVMRVKEDPYILCDRDIVSEMLDALQLRLSLIGGMFDTVCRNANLENWSLVMVQLLLYGIVTEEKNQALFYTCVDILCVLLLSCLLPDSAGFSFSGQERTNEDCKRIYNNVIKKLKKEIGDRQMPSLRCVHQLLPIPRQMVDVIVCDEYGLQPQKGSRGGFSSSEVTQRKGLQIIGKEKLNPWEIIEGYNRENIGLKWSWFQGIRLDYQPETLFEQMMRMLPHDHHHAFNRPPMPGEPRSDPFLETLQVHYVPCTNETSDSDKLTTERLKSNGSVAISGGTLVSEFSDQVQSPRTTKARPRKSTRGRKSSSRVTVSSNVALSSVPPMVQNRQLSIGQPTITAHYGYFPQQVAMTGGPSGAVPPYGQGQMWSIGNVQSASTAVPPTQYQSRNFTGAQMAPMQSSSGKQAISAMIRGRRPSGSGGQQMMSAAHIQPAPLAAGQPYHQQQLHSIGQVDPMVAPMHQVQMQMDAVSLTNFTTFVRFVFCLIFVLHYFSFQRQQLMQESMMEQQMRTPGPRSMATQQHCLPQVNSAASQPVMHGNYSNYPGQHGAARMQITSGRNQYVAQPAQPPFNCSPNYNAQFYQAQNAGQMRMPQTDVIAQSNVRYTQQPNYQMQSQQTLRAPAGYVAQQANPMYAAPNTPQYQAAQQQNVSMYPVSRMSQYSSNVPGQEMNASQQQINYYPPQY
Length2100
PositionKinase
OrganismTrichinella zimbabwensis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.09
Grand average of hydropathy-0.238
Instability index47.15
Isoelectric point7.03
Molecular weight238404.23
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06281
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.84|      28|      36|     848|     883|       1
---------------------------------------------------------------------------
  851-  866 (19.57/12.36)	..................FIQLESVM..CNIWRSLL
  867-  902 (36.26/33.08)	LYVKSKTVVnsfsaERCvWVYLHDLYqcCSYIRSLH
  905-  933 (47.01/29.58)	LYLNSRDCI.....QRClCVETKPSS..CNDLRGLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     523.29|     177|     191|    1133|    1322|       2
---------------------------------------------------------------------------
  213-  299 (27.80/ 7.43)	............................................................................CHyRHWqytTKlTRHLFEEGLLDKEI.LLNGLLdifaEKIYASSfgILKMIV........PVLLQFIDgfvmSVLLSRRLVylaCKVLSAM.KIDNL..............................................................
 1133- 1322 (276.92/222.94)	DGMVPDAILTL.LIAILmlddskVQELKSkenFDTKRSAKQFVEEDTNTAGNSD..........IGSTAIQLLELICR.QEW...TK.RKFLHSTDLFDPKR.LLNPLV....NQTQAQR..LLRMITRS....DSEILLKKFD....SCTTKKELI...SKVLDSL.TIMNL..WvSQMDLQLLLKQ.VANSQSESLHL..VDTIaksC...MEVFQP.QATLTF.GEPSDDKD
 1328- 1519 (218.57/149.19)	NALSFDEIAPYwLVAPL......ISRLPS...FVQGRVLKAAVSILENCQARRDrnlfaqssslLAHQPFLSLVLIC..............LRGQD..DQREgLLSSLL....KQIQ.EF..VMRVKEDPyilcDRDIVSEMLD....ALQLRLSLI...GGMFDTVcRNANLenW.SLVMVQLLLYGiVTEEKNQALFYtcVDIL...CvllLSCLLPdSAGFSFsGQERTNED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.61|      37|      41|    1669|    1707|       3
---------------------------------------------------------------------------
 1669- 1707 (56.61/49.31)	PCTneTSDSDKLTTERLKSNGSVAISGGTLVSEFSDQVQ
 1709- 1745 (61.00/45.75)	PRT..TKARPRKSTRGRKSSSRVTVSSNVALSSVPPMVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     136.00|      30|      30|    1998|    2027|       4
---------------------------------------------------------------------------
 1925- 1954 (23.79/ 9.98)	........QMRTPgprsmatQ..QHCLPQVNSAASQPV.........M.....H
 1955- 1998 (29.17/14.11)	GNYSNyPGQHGAA.......R..MQITSGRN.QYVAQPaqppfncspNynaqfY
 1999- 2027 (47.82/28.43)	.QAQN.AGQMRMP.......Q..TDVIAQSNVRYTQQP.........N.....Y
 2069- 2095 (35.22/18.76)	YPVS......RMS.......QysSNVPGQEMNASQQQI.........N.....Y
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.85|      24|      39|     727|     752|       5
---------------------------------------------------------------------------
  727-  752 (30.86/24.52)	GLIRVRKIIDSESLCsLSrKIQNLVF
  766-  789 (43.99/25.13)	GIVQFNSFINGQSNC.LP.TLENFDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     237.84|      77|     193|     422|     504|       7
---------------------------------------------------------------------------
  422-  504 (120.56/91.24)	QHFLSIldclDKFKFEYVNETNNIDTLYKTIFQ.SEKKEIRVDMDSIAVQ.........F.LCHWAVsPHRyGSYRAAVVTR...LFERHLQELSKK
  611-  701 (117.27/71.01)	EHFKPI....ENVDFNYFKDSDESKLDFDRIIDfADKKAISSDADSCSSKrvpklskhyFnVLHFPV.PQD.DQYRHECNQRqllLFGSNFDQYSRK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.93|      28|      48|     944|     971|       9
---------------------------------------------------------------------------
  944-  971 (48.48/33.34)	VLFQESDLVIEPNL.IQRLVENANLCYAF
  993- 1021 (49.45/34.18)	VLFCADVTALCPNLnADWLAVFKILCCPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.55|      27|      41|    1598|    1624|      10
---------------------------------------------------------------------------
 1598- 1624 (52.24/30.82)	PWEIIEGYNRENI.GLKWS..WFQGIRLDY
 1638- 1667 (43.31/24.32)	PHDHHHAFNRPPMpGEPRSdpFLETLQVHY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.43|      18|      19|    1766|    1784|      11
---------------------------------------------------------------------------
 1766- 1784 (29.56/20.04)	QVAMTGGPSGAVPPyGQGQ
 1787- 1804 (29.87/14.91)	SIGNVQSASTAVPP.TQYQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.42|      13|      30|    1837|    1849|      16
---------------------------------------------------------------------------
 1837- 1849 (24.81/12.95)	SGGQ..QMMSAAH.IQ
 1866- 1881 (16.62/ 6.48)	SIGQvdPMVAPMHqVQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06281 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GTLVSEFSDQVQSPRTTKARPRKSTRGRKSSSRVTVSSNVALSSVPPMVQNRQLSI
2) MRMPQTDVIAQSNVRYTQQPNYQMQSQQTLRAP
3) RMLPHDHHHAFNRPPMPGEPRSDPFLETLQ
1696
2006
1635
1751
2038
1664










Molecular Recognition Features






MoRF SequenceStartStop




1) YYPPQY
2095
2100